DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KDM4D and Kdm4d

DIOPT Version :9

Sequence 1:	NP_060509.2	Gene:	KDM4D / 55693	HGNCID:	25498	Length:	523	Species:	Homo sapiens
Sequence 2:	NP_775609.2	Gene:	Kdm4d / 244694	MGIID:	3606484	Length:	510	Species:	Mus musculus

Alignment Length:	512	Identity:	365/512 - (71%)
Similarity:	410/512 - (80%)	Gaps:	10/512 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     4 MKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISE 68
            ||:|:.|||||||:||||.||||||||||||||||||||||||||||:||||||:||::|||||.
Mouse     1 MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQSYDNISN 65

Human    69 ILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNS 133
            ||||||||||.||:||||||||||||.|||||||.||||||||||||.:||||||||||||:|.|
Mouse    66 ILIATPLQQVVSGQAGVFTQYHKKKKGMTVGEYRELANSKKYQTPPHLDFEDLERKYWKNRLYES 130

Human   134 PIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDL 198
            ||||||:||||||..|:|||:|||||||||||:|||:||||||||||||||||||||||||||||
Mouse   131 PIYGADVSGSLFDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDL 195

Human   199 YSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNR 263
            |||||||.|:|||||.||||||:||||||||||||||:||.||||||||||||||||||||||.|
Mouse   196 YSINYLHFGQPKTWYAVPPEHGRRLERLARELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGR 260

Human   264 ITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRIL 328
            ||||||||||||||||||||||||||||||||||||||||||:|||||||||||:||||||||||
Mouse   261 ITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRIL 325

Human   329 QPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARS 393
            |||||:|||||||:|||||.|..|..||||:|::..:.||: ..||::|.......|..|:|..|
Mouse   326 QPERYELWKRGQDQAVVDHTETMVSTSQELTTRRVTKAPRK-TWGLKRLRLRQVSRSLLPIATVS 389

Human   394 GTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQ 458
            ...|:..||.:..:.|.|.|...| ::.:..:|..|.|.|||.        |.|..|...||.|.
Mouse   390 NVPCNMQVCHTSRQPSDVKGDDVQ-KSDSARASPHPLSLPSSG--------HMSTRRCSLGRRPC 445

Human   459 KLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKAS 515
            :|.|||.:...|.||.|.||...|:..||.:|....|.|:.....::||.||.:.||
Mouse   446 ELGAQESSNGAPVKRQLPAGRDDTSPSPELQPQAVSGDLIVDSGLVNPGPQHLMTAS 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KDM4D	NP_060509.2	JmjN	19..53	CDD:280526	31/33 (94%)
		JmjC	179..295	CDD:202224	108/115 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..523		38/109 (35%)
Kdm4d	NP_775609.2	JmjN	15..55	CDD:128818	37/39 (95%)
		JmjC	176..292	CDD:334913	108/115 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..510		40/115 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83962298
Domainoid	1	1.000	244	1.000	Domainoid score	I20335
eggNOG	1	0.900	-	-		E1_COG5141
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69244
Inparanoid	1	1.050	738	1.000	Inparanoid score	I8708
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG58782
OrthoDB	1	1.010	-	-		D1186832at2759
OrthoFinder	1	1.000	-	-		FOG0000582
OrthoInspector	1	1.000	-	-		oto112614
orthoMCL	1	0.900	-	-		OOG6_111638
Panther	1	1.100	-	-	LDO	PTHR10694
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12927
SonicParanoid	1	1.000	-	-		X12031
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300