DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FRMD4A and frmd4a

DIOPT Version :9

Sequence 1:	XP_006717520.1	Gene:	FRMD4A / 55691	HGNCID:	25491	Length:	1110	Species:	Homo sapiens
Sequence 2:	XP_002935289.2	Gene:	frmd4a / 733886	XenbaseID:	XB-GENE-5922925	Length:	1085	Species:	Xenopus tropicalis

Alignment Length:	1092	Identity:	931/1092 - (85%)
Similarity:	985/1092 - (90%)	Gaps:	50/1092 - (4%)

- Green bases have known domain annotations that are detailed below.

Human    32 VLQLLLKPWCISRAVY-------------QMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVA 83
            |||..:.|....|.::             :|||||||||||||||||||||||||||||||||||
Frog    31 VLQTAVTPGRARRLLFRIPYGSLRRRSGERMTEGRRCQVHLLDDRKLELLVQPKLLAKELLDLVA 95

Human    84 SHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPVVLYFCVRFYIESISYLKDNATI 148
            ||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||||
Frog    96 SHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEHDFPKKSGPIVLYFCVRFYIESISYLKDNATI 160

Human   149 ELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSSFLGPLYDRTKEQRATNEVVRSDLKK 213
            |||||||||||||||||||||||||||:||||||||||:|               ::..|:||||
Frog   161 ELFFLNAKSCIYKELIDVDSEVVFELAAYILQEAKGDFTS---------------DDFTRADLKK 210

Human   214 LPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIP 278
            ||||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||
Frog   211 LPALPTQALKEHPSLAYCEDRVIEYYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIP 275

Human   279 WWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVH 343
            ||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||.|||||
Frog   276 WWLGLSYKGIFQYDHHDKVKPRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHGGIAVH 340

Human   344 TWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK 408
            |||||.|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Frog   341 TWYACAALIKSIWAMAISQHQFYLDRKQSKSKIHAARSLSEIAIDLTETGTLKTSKLANMGSKGK 405

Human   409 IISGSSGSLLSSGSGARRHCILLPGSQESDSSQSAKKDMLAALKSRQEALEETLRQRLEELKKLC 473
            ||||||||||||            |||||||||||||||||||||||||||||||||:|||||||
Frog   406 IISGSSGSLLSS------------GSQESDSSQSAKKDMLAALKSRQEALEETLRQRIEELKKLC 458

Human   474 LREAELTGKLPVEYPLDPGEEPPIVRRRIGTAFKLDEQKILPKGEEAELERLEREFAIQSQITEA 538
            :||||||||||.|||||||||||.|||||||:|||||||:|.||||.||||||||||||||||||
Frog   459 VREAELTGKLPREYPLDPGEEPPTVRRRIGTSFKLDEQKLLAKGEEVELERLEREFAIQSQITEA 523

Human   539 ARRLASDPNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIASEDS 603
            ||||||||:||:||||||||||||||||||||||:|||.|||||||||||||||||:.|:.||||
Frog   524 ARRLASDPHVSRKLKKQRKTSYLNALKKLQEIENSINEYRIKSGKKPTQRASLIIDEANLGSEDS 588

Human   604 SLSDALVLEDEDSQVTSTISPLHSPHKGLPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKP 668
            |||||||||||||||.|.:||:.|||||||||||||.||.|||||:||||:||.|||||||||||
Frog   589 SLSDALVLEDEDSQVPSILSPMQSPHKGLPPRPPSHARPHPPQSLDGLRQLHYQRNDYDKSPIKP 653

Human   669 KMWSESSLDEPYEKVKKRSSHSHSSSHKRFPSTGSCAEAGGGSNSLQNSPIRGLPHWNSQSSMPS 733
            ||||||||||||||:||||||||||.||||||||||:|| |||:||||||||.||||||||||||
Frog   654 KMWSESSLDEPYEKLKKRSSHSHSSHHKRFPSTGSCSEA-GGSSSLQNSPIRTLPHWNSQSSMPS 717

Human   734 TPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSS 798
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
Frog   718 TPDLRVRSPHYVHSTRSVDISPTRLHSLAQHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSS 782

Human   799 NGSDPMDDCSSCTSHSSSEHYYPAQMNANYSTLAEDSPSKARQRQRQRQRAAGALGSASSGSMPN 863
            |||||||||||||||||||||||.|||.||||||||||||||:|||.:.::.|.|.|::||||||
Frog   783 NGSDPMDDCSSCTSHSSSEHYYPTQMNPNYSTLAEDSPSKARERQRHKYKSNGNLVSSNSGSMPN 847

Human   864 LAARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLYIEGGATPVVVRSLESDQEGHYSVKAQFK 928
            ||||.|.|     ..|||||||||||||||||||||||||.::||||||||:|||||||||||||
Frog   848 LAARNGTG-----HHGVYLHSQSQPSSQYRIKEYPLYIEGSSSPVVVRSLENDQEGHYSVKAQFK 907

Human   929 TSNSYTAGGLFKESWRGGGGDEGDTGRLTPSRSQILRTPSLGREGAHDKGAGRAAVSDELRQWYQ 993
            |||||||||::||:|.  |.|..|:.|||||||||:|||||||||: :||.||..||:||||||.
Frog   908 TSNSYTAGGMYKENWH--GDDSVDSVRLTPSRSQIVRTPSLGREGS-EKGPGRTVVSNELRQWYH 969

Human   994 RSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTFVAHSRVTRMPQMCKATSAALPQSQRSSTPSS 1058
            |||:|||||:|||||||.|||||||||| |||||||||||||||.:||||:||||..||||||.|
Frog   970 RSTSSHKEHNRLSHTSSNSSDSGSQYST-SQSTFVAHSRVTRMPPVCKATTAALPHGQRSSTPCS 1033

Human  1059 EIGATPPSSPHHILTWQTGSYNDSCFLDSSLYPELADVQWYGQEKAKPGTLV 1110
            ::.|||||||||||:|||||||||.:|||:||.|||||||||||||||||||
Frog  1034 DLTATPPSSPHHILSWQTGSYNDSFYLDSALYQELADVQWYGQEKAKPGTLV 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FRMD4A	XP_006717520.1	B41	54..269	CDD:214604	190/214 (89%)
		FERM_N	57..118	CDD:286467	60/60 (100%)
		FERM_M	140..269	CDD:278785	105/128 (82%)
		FERM_C_FRMD4A_FRMD4B	265..375	CDD:270012	106/109 (97%)
		DUF3338	429..551	CDD:288652	108/121 (89%)
frmd4a	XP_002935289.2	FERM_F1_FRMD4B	63..151	CDD:340720	86/87 (99%)
		B41	66..266	CDD:214604	190/214 (89%)
		FERM_C_FRMD4A_FRMD4B	262..372	CDD:270012	106/109 (97%)
		DUF3338	401..535	CDD:371743	124/145 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	885	1.000	Domainoid score	I936
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9971
Inparanoid	1	1.050	1792	1.000	Inparanoid score	I918
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39456
OrthoDB	1	1.010	-	-		D125121at2759
OrthoFinder	1	1.000	-	-		FOG0004021
OrthoInspector	1	1.000	-	-		oto150817
Panther	1	1.100	-	-	LDO	PTHR46079
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X8023
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.080