Protein Alignment FRMD4A and Mer

DIOPT Version :9

• Sequence 1: XP_006717520.1
• Gene: FRMD4A / 55691
• HGNCID: 25491
• Length: 1110
• Species: Homo sapiens
• Sequence 2: NP_001285458.1
• Gene: Mer / 32979
• FlyBaseID: FBgn0086384
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 594
• Identity: 136/594 - (22%)
• Similarity: 240/594 - (40%)
• Gaps: 111/594 - (18%)

Human    62 DRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGHLNWLQLDRRVLEH--DFPKKSG 124
            |.:||..::|:...::|.|||.....|:|..|||:.:.|...:::||::::||.:.  :....:.
  Fly    20 DSELEFKLEPRASGQDLFDLVCRTIGLRESWYFGLQYVDTRSNVSWLKMEKRVRDQRVELHASNN 84

Human   125 PVVLYFCVRFYIESIS-YLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYILQEAKGDFSS 188
            ..|..|..:|:.|::| .|....|..||||..|..|....|....|....||||.:....|.:.
  Fly    85 VYVFSFYAKFFPENVSEELIQEITQHLFFLQVKQSILSMDIYCRPEASVLLASYAVHVQYGPYD- 148

Human   189 FLGPLYDRTKE-QRATNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLNGQTRGQAIV 252
                 |:..|: ..|..|:       ||...|...:..|.:  .|:|:...|......||.:..:
  Fly   149 -----YETYKDGMLAGGEL-------LPKGVTDQYQMTPEM--WEERIKTWYMDHEPMTRDEVEM 199

Human   253 NYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVKPRKIFQWRQLENLYFREKK 317
            .|:.|.:.|..|||:|:.:.:|.....|||::..|:..||..||:.|:..|||.::.::.|.:||
  Fly   200 EYLKIAQDLDMYGVNYFPITNKNKTKLWLGVTSVGLNIYDERDKLTPKTTFQWNEIRHVSFDDKK 264

Human   318 FSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQHQFYLDRKQSKSKIHAARSL 382
            |::.:.|   |.|:...|....:.::         |.|..:....|..|:.|::.
  Fly   265 FTIRLVD---AKVSNFIFYSQDLHIN---------KMILDLCKGNHDLYMRRRKP---------- 307

Human   383 SEIAIDLTETGTLKTSKLANMGSKGKIISGSSGSLLSSGSGARRHCILLPGSQESDSSQSAKKDM 447
                         .|.::..|.::.|                          :|....|..:|..
  Fly   308 -------------DTMEIQQMKAQAK--------------------------EEKQRRQIERKKF 333

Human   448 LAALKSRQEA------LEETLRQRLEELKKL--CLREAELTGKLPVEYPLDPGEEPPIVRRRIGT 504
            :...|.|::|      ||:::.....|::..  .||.:|.|.:|..|......|:..:...: ..
  Fly   334 IREKKLREKAEHERYELEKSMEHLQNEMRMANDALRRSEETKELYFEKSRVNEEQMQLTECK-AN 397

Human   505 AFK-----LDEQKILPKGEEAELERLER--EFAIQSQITEAARRLASDPNVSKKLKKQ---RKTS 559
            .||     |.|:::..:.|:.:||:..|  :|.:.....|..:|.|.    ::||:|:   .|.:
  Fly   398 HFKTEMDRLRERQMKIEREKHDLEKKIRDADFYVHQLTVENDKREAE----TEKLRKELICAKMA 458

Human   560 YLNALKKLQEIENAINENRIKSGKKPTQRASLIIDDGNIASEDSSLSDALVLEDEDSQVTSTIS- 623
            ...|..:|.|.   :|..| ||.......||.:....|.||..:::|...::....:....|..
  Fly   459 EREATARLLEF---LNSGR-KSSTDSLLTASSVSHAANTASSMAAISTPSLITSSSTNDLETAGG 519

Human   624 ---PLHSPH 629
               ..||.|
  Fly   520 AELTTHSSH 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD4A	XP_006717520.1	B41	54..269	CDD:214604	57/210 (27%)
		FERM_N	57..118	CDD:286467	18/57 (32%)
		FERM_M	140..269	CDD:278785	35/130 (27%)
		FERM_C_FRMD4A_FRMD4B	265..375	CDD:270012	29/109 (27%)
		DUF3338	429..551	CDD:288652	28/136 (21%)
Mer	NP_001285458.1	B41	14..216	CDD:214604	57/210 (27%)
		FERM_C_ERM	210..306	CDD:270015	30/107 (28%)
		ERM	341..635	CDD:395622	44/197 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3529
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810