Protein Alignment FRMD4A and F07C6.4

DIOPT Version :9

• Sequence 1: XP_006717520.1
• Gene: FRMD4A / 55691
• HGNCID: 25491
• Length: 1110
• Species: Homo sapiens
• Sequence 2: NP_001255674.1
• Gene: F07C6.4 / 178235
• WormBaseID: WBGene00008555
• Length: 977
• Species: Caenorhabditis elegans
• Alignment Length: 1135
• Identity: 268/1135 - (23%)
• Similarity: 443/1135 - (39%)
• Gaps: 342/1135 - (30%)

Human    57 VHLLDDRKLELLVQPKLLAKELLDLVASHFNLK--EKEYFGIAFTDETGHLNWLQLDRRVLEHDF 119
            :.|||.:::|:::..:|..:::|.|||...:|.  :.:||.:.|:|...:.:|  ||..|:.:|.
 Worm    18 IRLLDSQQIEVVLHSRLSVEDVLRLVAEKVDLSFPDSQYFCLGFSDNLNNFHW--LDGSVILYDL 80

Human   120 ------PKKSGPVVLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASYI 178
                  ||  |.:.|...|||::::|..::..:|.:|||.:..:.:.:..:.|.||..|||.:.:
 Worm    81 VASTSNPK--GTLTLSHHVRFFVDTIYEVQCASTAKLFFFDIHNQLARHELLVTSEDYFELVAIL 143

Human   179 LQEAKGDFSSFLGPLYDRTKEQRATNEVVRSDLKKLPALPTQALKEHPSLAYCEDRVIEHYKKLN 243
            :       |.|:....:.|     |.|.: |.:..:...|...||...|  ..|.||.|.::...
 Worm   144 V-------SVFVPDCQEHT-----TAEAI-SRIMPMSHPPYILLKTDQS--EVERRVFEKFRYYR 193

Human   244 GQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQY---DYHDKVKPRKIFQW 305
            ....|..:::::.:.|...:||...|...::......|.:.||||:.|   .:.:.:.|...:.|
 Worm   194 RLPVGTGMISFIKLAEKSESYGYRMYEALNENNDKCILSIGYKGIYIYRRSRHQNLITPYLAYPW 258

Human   306 RQLENLYFREKKFSVEVHDPRRASVTR---------------RTFGHSGIAVHTW---------- 345
            |.::|||:|:||||:|:.:|::...:.               ..|.|....|...
 Worm   259 RVIDNLYYRDKKFSIEIREPKKNESSENVSDDVILINDRQLSEAFSHPTTQVSCGRRRSNNQQPR 323

Human   346 -----YAC--PALIKSIWAMAISQHQFYLDRKQSKSKIH--------AARSLSEIAIDLTETGTL 395
                 :.|  |.:.:::|..||:||:|:|:||:.|.|.|        ..:.|:|....||.|.:|
 Worm   324 VLLFPFTCQTPLVCRTVWMSAIAQHRFFLERKELKKKGHHHSRNAVVDHQELTEKLNRLTSTSSL 388

Human   396 KTS--KLANMGS--------KGKIISGSSGSLLSSGS---GARRHCILLPGSQESDSSQSAK--- 444
            .:|  .|:::.|        ..||..||:.||..|.:   ..:.....||...|.:.|...|
 Worm   389 GSSLPSLSSLHSNSSIGTMPSAKIGDGSTSSLPMSSAKPMSTQTSEPQLPDVPEPNESLHNKTID 453

Human   445 -----KDMLAALKSRQEALEETLRQRLEELKKLCLREAELTGKLPVEY--PLDPGEEPPIVRRRI 502
                 ::....||:|:..||..|||:::|||.:|:.|.::||::|||.  .:.||::.|.::||:
 Worm   454 EFQKDQEKCDRLKARKAELEMRLRQKMQELKDVCVEEGDITGEMPVEINDVVLPGDDFPRLKRRV 518

Human   503 GTAFKLDEQKILPKGEEAE-LERLEREFAIQSQITEAARRLASDPNVSKKLKKQRKTSYLNALKK 566
            |||:.:.::.|  |.::|: :.:||.:..:..:|..||.|||:|.|.:|.::|:|:.....|..:
 Worm   519 GTAYSIPDELI--KADKADKMSQLETDVELHRRIVAAASRLATDKNTNKSVRKKRQKDLQAARLR 581

Human   567 LQEIENAINENRIKSGKKPTQRASLIIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLHSPHKG 631
            |..:|..:.:.| .|..|| ..:||..|..|..:..:|....|.:               :..|.
 Worm   582 LNRLEQGLQQMR-HSASKP-DISSLTSDSSNSWTASNSSGPMLTM---------------AMTKS 629

Human   632 LPPRPPSHNRPPPPQSLEGLRQMHYHRNDYDKSPIKPKMWSESSLDEPYEKVKKRSSHSHSSSHK 696
            .|..|    |...|....||        |.:|             ||..|.|:.|.|       :
 Worm   630 CPTTP----RGSVPDLRNGL--------DDEK-------------DEFDENVEDRVS-------R 662

Human   697 RFPSTGSCAEAGGGSNSLQNSPIRGLPHWNSQSSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSL 761
            |.||..|                                                      .|||
 Worm   663 RAPSAIS------------------------------------------------------RHSL 673

Human   762 ALHFRHRSSSLESQGKLLGSENDTGSPDFYTPRTRSSNGSDPMDD-------C------SSCTSH 813
            :..:...|||..|.|   ......|.|...|.|......:.|.||       |      ||..:|
 Worm   674 SQRYSGVSSSSTSSG---SDSMGLGLPPRPTSRKSQQQQTTPFDDQLDNPMICEIPPPPSSAAAH 735

Human   814 SSSEH-------YYPAQMNANYSTLAEDSPSKARQRQRQRQRAA-------GALGSASSGSMPNL 864
            ...|:       |..:...|:|.|:.::      ..||:|.::|       ||.|..|:.|:|
 Worm   736 PLYENVGYRSTSYRSSYRQAHYPTIQDE------HTQRKRAQSAHSISTDNGATGRTSTYSVP-- 792

Human   865 AARGGAGGAGGAGGGVYLHSQSQPSSQYRIKEYPLYIEGGATPVV--------VRSLESDQEGHY 921
                             |:..:|     :.:||....|..:||.:        ||.|.|.    .
 Worm   793 -----------------LNDAAQ-----KFREYDYDDEEDSTPTMDLPSHLINVRRLTSS----I 831

Human   922 SVKAQFKTSN-----SYTAGGLFKESWRGGGGDEGDTGRLTPSRSQILRTPSLGREGAHDKGAGR 981
            |.:|.|.|::     |...||....   ||||.:
 Worm   832 SCQAGFATASLDRRYSKLNGGRLSS---GGGGSD------------------------------- 862

Human   982 AAVSDELRQWYQRSTASHKEHSRLSHTSSTSSDSGSQYSTSSQSTF-----VAHSRVTRMPQMCK 1041
                |.:||    :..:......::.:::|...||..||.|....|     ||  |||.||
 Worm   863 ----DVVRQ----NVTTRITTFPVATSAATVILSGKPYSASELPRFQPPPPVA--RVTHMP---- 913

Human  1042 ATSAALPQSQRSSTP---SSEIGATPPSSP 1068
                      |.|.|   |:.:||..|:.|
 Worm   914 ----------RGSLPPYSSATMGAQSPAPP 933

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FRMD4A	XP_006717520.1	B41	54..269	CDD:214604	55/219 (25%)
		FERM_N	57..118	CDD:286467	18/62 (29%)
		FERM_M	140..269	CDD:278785	28/128 (22%)
		FERM_C_FRMD4A_FRMD4B	265..375	CDD:270012	36/144 (25%)
		DUF3338	429..551	CDD:288652	44/132 (33%)
F07C6.4	NP_001255674.1	B41	18..219	CDD:214604	55/219 (25%)
		FERM_C_FRMD4A_FRMD4B	215..360	CDD:270012	36/144 (25%)
		DUF3338	416..565	CDD:371743	48/150 (32%)
		DAZAP2	900..>977	CDD:371348	16/50 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470976
Domainoid	1	1.000	76	1.000	Domainoid score	I6292
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	197	1.000	Inparanoid score	I2851
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004021
OrthoInspector	1	1.000	-	-		otm16496
orthoMCL	1	0.900	-	-		OOG6_106286
Panther	1	1.100	-	-	O	PTHR46079
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.890