DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tfec and Mitf

DIOPT Version :9

Sequence 1:	NP_001025276.2	Gene:	tfec / 556894	ZFINID:	ZDB-GENE-041210-21	Length:	396	Species:	Danio rerio
Sequence 2:	NP_001245436.1	Gene:	Mitf / 3885647	FlyBaseID:	FBgn0263112	Length:	837	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	140/491 - (28%)
Similarity:	201/491 - (40%)	Gaps:	162/491 - (32%)

- Green bases have known domain annotations that are detailed below.

Zfish    17 RVANVQSHLEN-SKYHLNQTQAQQVKQYLA-------LGS-----KLASQA------------HP 56
            :|..|.:.||| ::||:.|.|..||:|||:       .||     |||:.:            ..
  Fly   275 QVLQVSTVLENPTRYHVIQKQKNQVRQYLSESFKPSMWGSHTSEIKLANNSASTGNLQNSSLQKG 339

Zfish    57 VAHPLP-------GQALGTVPVMRNGHMPPVS---------DSSTPGSPVTLLTLANNHDSEFPM 105
            :..||.       ..|:....:|.:....|:|         |...|..|..|  ..|:|.:..|.
  Fly   340 ICDPLERTNRFGCDSAVSAKRIMPSDDAMPISPFGGSFVRCDDINPIEPTVL--RPNSHGAGEPE 402

Zfish   106 DEVIDDLIGLENGFKDGSLDCMEPGIIMQNNVSLNSSMLEVYGA--------------------- 149
            :......:||.......|......||:....:|..||.|:...|
  Fly   403 NAHRTAQLGLSKANSSLSSTRSSSGIVNSIRISSTSSSLQSTSAPISPSVSSVATSVSEPDDIFD 467

Zfish   150 ----------DQEHDTRV----------------LAKERQKKDNHNLIERRRRYNINYRIKELGT 188
                      |:..::.:                |||:||||||||:||||||:|||.|||||||
  Fly   468 DILQNDSFNFDKNFNSELSIKQEPQNLTDAEMNALAKDRQKKDNHNMIERRRRFNINDRIKELGT 532

Zfish   189 LIPKSNDP------DMRWNKGTILKASVEYIKWLQKEQQHARDLESRQKKLEQANRRLQLRIQEL 247
            |:||.:|.      |:|.|||||||:||:|||.|:.|....|..|.||:::|..||:|..||:||
  Fly   533 LLPKGSDAFYEVVRDIRPNKGTILKSSVDYIKCLKHEVTRLRQNELRQRQVELQNRKLMSRIKEL 597

Zfish   248 EIQAHAHGLPSMTASMGTVELSSHLLKQQHHQTQATAASQSAQAPQSTQPPIYPQEGVSSPEYTQ 312
            |:||.:||                :|..::|.|       |..||  |||  |.:....||  |.
  Fly   598 EMQAKSHG----------------ILLSENHLT-------SLSAP--TQP--YLKSFSLSP--TA 633

Zfish   313 RTSLPSI----------VGEQSDGSNNFSDPLSHFTYFFCSTLKEEHQRLDEILMDDPLSPFGTD 367
            ..|..|:          |.:.:||:...:                   ::||.:.|...:..|.|
  Fly   634 SRSRRSLFDQPVEKKIQVIDGADGNMGMN-------------------QVDEFMEDCKYAVQGGD 679

Zfish   368 PLLSAGS-----PTAASKESSRRSSFSSE---ETDD 395
            |:||:.|     |.:.|.::....||..:   |.|:
  Fly   680 PMLSSHSHMQSAPQSPSSKTLNSGSFEPKNFSEADE 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tfec	NP_001025276.2	MITF_TFEB_C_3_N	<17..109	CDD:292573	32/132 (24%)
		HLH	161..221	CDD:238036	44/65 (68%)
		Ax_dynein_light	<204..>251	CDD:287215	24/46 (52%)
		DUF3371	249..377	CDD:288684	32/142 (23%)
Mitf	NP_001245436.1	MITF_TFEB_C_3_N	<272..>311	CDD:292573	14/35 (40%)
Mitf	NP_001245436.1	HLH	505..570	CDD:238036	43/64 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593392
Domainoid	1	1.000	85	1.000	Domainoid score	I8110
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1211990at2759
OrthoFinder	1	1.000	-	-		FOG0000691
OrthoInspector	1	1.000	-	-		otm24979
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45776
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X566
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	9.000