Protein Alignment YEATS2 and Yeats2

DIOPT Version :10

• Sequence 1: NP_001338299.1
• Gene: YEATS2 / 55689
• HGNCID: 25489
• Length: 1423
• Species: Homo sapiens
• Sequence 2: NP_001102527.1
• Gene: Yeats2 / 498112
• RGDID: 1566176
• Length: 1405
• Species: Rattus norvegicus
• Alignment Length: 1424
• Identity: 1221/1424 - (85%)
• Similarity: 1293/1424 - (90%)
• Gaps: 20/1424 - (1%)

Human     1 MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVID 65
            |||||||||||||||||||||||:|||||||:|||||||||||||||||||||||||||||:|||
  Rat     1 MSGIKRTIKETDPDYEDVSVALPSKRHKAIESSARDAAVQKIETIIKEQFALEMKNKEHEIDVID 65

Human    66 QRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRA 130
            |||||||||||||||||||||||||||||||||.||.|.|.|||||||||||||||||||.|||:
  Rat    66 QRLIEARRMMDKLRACIVANYYASAGLLKVSEGLKTFDPMAFNHPAIKKFLESPSRSSSPTNQRS 130

Human   131 ETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNA 195
            ||||||||||||||||||||||||||||:|:|||||:..|||.|||||||||.|:||||.|.|:|
  Rat   131 ETPSANHSESDSLSQHNDFLSDKDNNSNVDVEERLSSIGEQRLSRNTGRDTSSISGSHKRELRSA 195

Human   196 DLT-DETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLH 259
            ||. |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   196 DLAGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLH 260

Human   260 PSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETV 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   261 PSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETV 325

Human   325 VDVELHRHSLGEDCIYPQSSESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKAGFPAS 389
            |||||||||||||.:||||||||||||||. .||||||||| ||:.:|.||.....|.: |||.|
  Rat   326 VDVELHRHSLGEDYVYPQSSESDISDAPPP-SLTIPAPVKA-SPVARSPEPASAAPVGE-GFPDS 387

Human   390 TEAERHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQ 454
            ||||||:..|:|||||||||||:|.:|||||.|||||||||||||||||||||||||||||||||
  Rat   388 TEAERHSTLYSLPSSLERTPTKVTAAQKVTFSSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQ 452

Human   455 PITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTG 519
            ||||||||||||||||||||||||||||||||:|||:|.:.|:||:.|:|| |||..||:.||.|
  Rat   453 PITMSCKIVSGSPISTPSPSPLPRTPTSTPVHLKQGSASAGISNPHAIVDK-PGQATGASAPSAG 516

Human   520 SPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGL 584
            |||:|:..|||.||||||||||||||||:||||||||||||||||||||||||||||||.:||||
  Rat   517 SPTSKLPVASQASQGTGSPVPKIHGSSFLTSTVKQEDSLFASMPPLCPIGSHPKVQSPKAVTGGL 581

Human   585 GAFTKVIIKQEPGEAPHVPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPS 649
            ||||||||||||||.|||..||||:||..||||||||||||||||||||::.||||.||.|:.||
  Rat   582 GAFTKVIIKQEPGETPHVSTTGAANQSAFPQYVTVKGGHMIAVSPQKQVLSAGEGITQSPKIPPS 646

Human   650 KVVGVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQP 714
            ||||||||||||||||||||||.|||||||||||::|||||||||||||||||||||||||||||
  Rat   647 KVVGVPVGSALPSTVKQAVAISSGQILVAKASSSITKAVGPKQVVTQGVAKAIVSGGGGTIVAQP 711

Human   715 VQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIP 779
            ||||||.|||||||.|:||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   712 VQTLTKTQVTAAGPPKTGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIP 776

Human   780 QGAILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGPGGI 844
            |||||||||||||||||||:||||...|.|||||||.|:              ||..||:||||.
  Rat   777 QGAILRATNNANLQSGSAAAGGSGGSCGAGGGGGGGGGA--------------GGAPSTSGPGGG 827

Human   845 SQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTT 909
            .|||||||||||||||||||||||||||.||||||.||||||||||||||.||||||||||||||
  Rat   828 PQHLTYTSYILKQTPQGTFLVGQPSPQTPGKQLTTASVVQGTLGVSTSSAPGQQTLKVISGQKTT 892

Human   910 LFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSE 974
            ||||||..|||||:|:.|:|||:|||..||:|||||||||||||||.|.|||||.||||...|:|
  Rat   893 LFTQAATAGQASLLKLPDNTLKSVPAAPQLAKPGTTMLRVAGGVITAAPSPAVAFSANGAVHQAE 957

Human   975 GMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKATVSGLLKIH 1039
            |.|||||| |.|:.||.||.||||||||:.||||..|..|:|.|||..|:.||||||||||||||
  Rat   958 GSAPVSSS-VGSIIKTPGQPQVCVSQATMATCKATAPAAVTAASLVSAPSSISGKATVSGLLKIH 1021

Human  1040 SSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAP 1104
            |.|.|||||||||||||||||:||||||||:|||||||||||||||.|.:||::.|.|..||.||
  Rat  1022 SGQCSPQQAVLTIPSQLKPLSINTSGGVQTVLMPVNKVVQSFSTSKLPTVLPISVPNPAAPSPAP 1086

Human  1105 AAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKS 1169
            ..:||||||||||||:|:|||.|.||||||||||.||||::|||||||||||||||||||||||.
  Rat  1087 VTIAKVKTEPETPGPNCVSQETQIAVKTEESSELSNYVIQVDHLETIQQLLTAVVKKIPLITAKG 1151

Human  1170 EDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCH 1234
            .|.|||||||:|||||||||||||||||||||:|||||||||:||||||||.|||||||||||||
  Rat  1152 NDTSCFSAKSLEQYYGWNIGKRRAAEWQRAMTVRKVLQEILERNPRFHHLTALKTKHIAHWCRCH 1216

Human  1235 GYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILS 1299
            |||||||||||::|||||||||||||||||.||||:||:||||||||||||||||||||||||||
  Rat  1217 GYTPPDPESLRHNGDSIEDVLTQIDSEPECLSSFSTADDLCRKLEDLQQFQKREPENEEEVDILS 1281

Human  1300 LSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKA 1364
            ||||:|.||||||||||||::|||||||||.|:||:||||||||||||||||:||||||||||||
  Rat  1282 LSEPLKTNIKKEQEEKQEEMRFYLPPTPGSGFVGDITQKIGITLQPVALHRNMYASVVEDMILKA 1346

Human  1365 TEQLVNDILRQALAVGYQTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ 1423
            |||||:|||||||||||||||.|||||||||||||||||||||||||||||||.|||||
  Rat  1347 TEQLVSDILRQALAVGYQTASPNRIPKEITVSNIHQAICNIPFLDFLTNKHMGRLNEDQ 1405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YEATS2	NP_001338299.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..198		67/80 (84%)
		YEATS_YEATS2_like	208..331	CDD:341126	122/122 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	259..261		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	282..284		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..487		20/20 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..541		18/26 (69%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..843		23/47 (49%)
		DUF5585	<869..>1119	CDD:465521	193/249 (78%)
Yeats2	NP_001102527.1	YEATS_YEATS2_like	209..332	CDD:341126	122/122 (100%)
		PHA03247	<342..653	CDD:223021	253/314 (81%)