Protein Alignment YEATS2 and Yeats2

DIOPT Version :10

• Sequence 1: NP_001338299.1
• Gene: YEATS2 / 55689
• HGNCID: 25489
• Length: 1423
• Species: Homo sapiens
• Sequence 2: NP_001139402.1
• Gene: Yeats2 / 208146
• MGIID: 2447762
• Length: 1407
• Species: Mus musculus
• Alignment Length: 1425
• Identity: 1231/1425 - (86%)
• Similarity: 1303/1425 - (91%)
• Gaps: 20/1425 - (1%)

Human     1 MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVID 65
            |||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||:|||
Mouse     1 MSGIKRTIKETDPDYEDVSVALPNKRHKAIESSARDAAVQKIETIIKEQFALEMKNKEHEIDVID 65

Human    66 QRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRA 130
            |||||||||||||||||||||||||||||||||.||.|.|.|||||||||||||||||||.|||:
Mouse    66 QRLIEARRMMDKLRACIVANYYASAGLLKVSEGLKTFDPMAFNHPAIKKFLESPSRSSSPTNQRS 130

Human   131 ETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNA 195
            ||||||||||||||||||||||||||||:|:|||..:..||||||..|||||.|:||||.|.|||
Mouse   131 ETPSANHSESDSLSQHNDFLSDKDNNSNVDVEERPPSTGEQRPSRKAGRDTSSISGSHKRELRNA 195

Human   196 DLT-DETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLH 259
            ||| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 DLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLH 260

Human   260 PSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETV 324
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   261 PSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETV 325

Human   325 VDVELHRHSLGEDCIYPQSSESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKAGFPAS 389
            |||||||||||||.:||||||||:.||||. .||:||.||||: :.||.||.....|.: |||.:
Mouse   326 VDVELHRHSLGEDSVYPQSSESDVCDAPPP-TLTLPAAVKASA-VAQSPEPAAAAPVGE-GFPET 387

Human   390 TEAERHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQ 454
            ||||||:.||:|||||||||||:||:|||||.|||||||||||||||||||||||||||||||||
Mouse   388 TEAERHSTFYSLPSSLERTPTKVTTAQKVTFSSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQ 452

Human   455 PITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTG 519
            ||||||||||||||||||||||||||||||||:|||||.|.::||:||:|| |||||||:|||||
Mouse   453 PITMSCKIVSGSPISTPSPSPLPRTPTSTPVHLKQGTASSGVSNPHVIVDK-PGQVIGASTPSTG 516

Human   520 SPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGL 584
            |||:|:..|||.|||||||:||||||||:|||||||:||||||||||||||||||||||.:||||
Mouse   517 SPTSKLPVASQASQGTGSPIPKIHGSSFLTSTVKQEESLFASMPPLCPIGSHPKVQSPKAVTGGL 581

Human   585 GAFTKVIIKQEPGEAPHVPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPS 649
            ||||||||||||||||||..|||||||..|||||||||||||||||||||:.|||..||.|:.||
Mouse   582 GAFTKVIIKQEPGEAPHVSTTGAASQSAFPQYVTVKGGHMIAVSPQKQVISAGEGTTQSPKIAPS 646

Human   650 KVVGVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQP 714
            ||||||||||||||||||||||.||||||||||||:|||||||||||||||||||||||||||||
Mouse   647 KVVGVPVGSALPSTVKQAVAISSGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQP 711

Human   715 VQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIP 779
            ||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   712 VQTLTKTQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIP 776

Human   780 QGAILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGPGGI 844
            |||||||||||||||||||:||||:.|.|||             :|||||:..|||.||:||||.
Mouse   777 QGAILRATNNANLQSGSAAAGGSGSSGAGGG-------------SGGGGGSGAGGTPSTSGPGGG 828

Human   845 SQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTT 909
            .|||||||||||||||||||||||||||.||||||.||||||||||:||||||||||||||||||
Mouse   829 PQHLTYTSYILKQTPQGTFLVGQPSPQTPGKQLTTASVVQGTLGVSSSSAQGQQTLKVISGQKTT 893

Human   910 LFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSE 974
            ||||||..|||||:|:.|:|||:|||..||:|||||||||||||||.|.|||||.||||...|||
Mouse   894 LFTQAATAGQASLLKLPDNTLKSVPAAPQLAKPGTTMLRVAGGVITAAPSPAVAFSANGAVHQSE 958

Human   975 GMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKATVSGLLKIH 1039
            |..||||| |.|:.||.||.||||||||:.|||.......:|.|||..|:.||||||||||||:|
Mouse   959 GSTPVSSS-VGSIIKTPGQPQVCVSQATMATCKGPAAVAGTAASLVSAPSSISGKATVSGLLKVH 1022

Human  1040 SSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSK-PPAILPVAAPTPVVPSSA 1103
            |:|||||||||||||||||||:||||||||:||||||||||||||| |..:||::.|....||||
Mouse  1023 SAQSSPQQAVLTIPSQLKPLSINTSGGVQTVLMPVNKVVQSFSTSKLPTTVLPISVPNQAAPSSA 1087

Human  1104 PAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAK 1168
            |.|:||||||||||||:|:|||.|.||||||||||.|||||:|||||||||||||||||||||||
Mouse  1088 PVAIAKVKTEPETPGPNCISQENQVAVKTEESSELSNYVIKVDHLETIQQLLTAVVKKIPLITAK 1152

Human  1169 SEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRC 1233
            .:|||||||||:|||||||||||||||||||||:|||||||||||||||||||||||||||||||
Mouse  1153 GDDASCFSAKSLEQYYGWNIGKRRAAEWQRAMTVRKVLQEILEKNPRFHHLTPLKTKHIAHWCRC 1217

Human  1234 HGYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDIL 1298
            ||||||||||||:||||||||||||||||||.||||:||:|||||||||||||||||||||||||
Mouse  1218 HGYTPPDPESLRHDGDSIEDVLTQIDSEPECLSSFSTADDLCRKLEDLQQFQKREPENEEEVDIL 1282

Human  1299 SLSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILK 1363
            |||||:|.||||||||||||::|||||||||.|:||:||||||||||||||||:|||||||||||
Mouse  1283 SLSEPLKTNIKKEQEEKQEEMRFYLPPTPGSGFVGDITQKIGITLQPVALHRNMYASVVEDMILK 1347

Human  1364 ATEQLVNDILRQALAVGYQTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ 1423
            ||||||:|||||||||||||||.|||||||||||||||||||||||||||||||.|||||
Mouse  1348 ATEQLVSDILRQALAVGYQTASPNRIPKEITVSNIHQAICNIPFLDFLTNKHMGRLNEDQ 1407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YEATS2	NP_001338299.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..198		65/80 (81%)
		YEATS_YEATS2_like	208..331	CDD:341126	122/122 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	259..261		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	282..284		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..487		20/20 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..541		19/26 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..843		24/47 (51%)
		DUF5585	<869..>1119	CDD:465521	191/250 (76%)
Yeats2	NP_001139402.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..196		64/79 (81%)
		YEATS_YEATS2_like	209..332	CDD:341126	122/122 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000250|UniProtKB:Q9ULM3	260..262		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000250|UniProtKB:Q9ULM3	283..285		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	462..540		63/78 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..833		29/54 (54%)
		PRK07003	<887..>1123	CDD:235906	176/236 (75%)