Protein Alignment YEATS2 and Y105E8B.7

DIOPT Version :10

• Sequence 1: NP_001338299.1
• Gene: YEATS2 / 55689
• HGNCID: 25489
• Length: 1423
• Species: Homo sapiens
• Sequence 2: NP_493542.2
• Gene: Y105E8B.7 / 190914
• WormBaseID: WBGene00013692
• Length: 269
• Species: Caenorhabditis elegans
• Alignment Length: 231
• Identity: 62/231 - (26%)
• Similarity: 101/231 - (43%)
• Gaps: 37/231 - (16%)

Human   210 IVVGNVSKYIPPDKREENDQS--THKWMVYVRGSRRE----PSINHFVKKVWFFLHPSYKPNDLV 268
            ::||:.|..:|     ||:::  ||||.::|:...|:    |. |..::||.|.:|.|: ...:.
 Worm     6 VIVGHSSTRLP-----ENNENGHTHKWTLFVKPGNRDYDEFPD-NKLIQKVKFEIHESF-AQPVR 63

Human   269 EVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAET---VVDVELH 330
            .|.:|||.:|..|:..|...|.:.......|...|.:.|.|   :||.|.:..||   ||..::.
 Worm    64 FVTKPPFKITETGFASFTTLVTIFLNLPNEKPRTIPYELTL---FTGDQDVQLETQKLVVQKDVP 125

Human   331 RHSLGEDCIYPQSSESDIS-----DAPPSLPLTIPAPVK---ASSPIKQSHE---PVP--DTSVE 382
            ...|.....|.::.:...|     :..||..:....|||   :|..:.:|.|   |:|  |..:|
 Worm   126 PAYLELIKKYARTKKRKASLISNDEKSPSRKMHKITPVKEEESSQKMSKSKEKGVPIPKIDIEIE 190

Human   383 KAGFPASTEAERHTPFYALPSSLERTPTKMTTSQKV 418
            ||. |...:.|:    ...|..|.|...:.|.|..:
 Worm   191 KAS-PKKEKKEK----VKSPEELTRRLNECTDSHVI 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YEATS2	NP_001338299.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..198
		YEATS_YEATS2_like	208..331	CDD:341126	38/129 (29%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	259..261		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	282..284		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..541
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..843
		DUF5585	<869..>1119	CDD:465521
Y105E8B.7	NP_493542.2	YEATS_AF-9_like	4..133	CDD:341125	39/136 (29%)