Protein Alignment YEATS2 and yeats2

DIOPT Version :10

• Sequence 1: NP_001338299.1
• Gene: YEATS2 / 55689
• HGNCID: 25489
• Length: 1423
• Species: Homo sapiens
• Sequence 2: XP_002660941.4
• Gene: yeats2 / 100320774
• ZFINID: ZDB-GENE-081104-292
• Length: 1419
• Species: Danio rerio
• Alignment Length: 1536
• Identity: 791/1536 - (51%)
• Similarity: 981/1536 - (63%)
• Gaps: 234/1536 - (15%)

Human     1 MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVID 65
            |||:||.|::.||||||::....|||.:.:|.:|||||||||:.|||:||:||||:||||||||.
Zfish     1 MSGVKRKIEDKDPDYEDITQVQENKRSRVVEQNARDAAVQKIDAIIKDQFSLEMKSKEHEIEVIG 65

Human    66 QRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRA 130
            |||.||||||||||||||||||||||..||...:...|..|.||||||:||:||||||||.||.:
Zfish    66 QRLNEARRMMDKLRACIVANYYASAGQPKVLPEASKSDPSVLNHPAIKRFLDSPSRSSSPLNQNS 130

Human   131 ETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNA 195
            :|||...||::||||..:....:.::...|...|     |:||.||||:||..:..|.:......
Zfish   131 DTPSQVQSETESLSQQGEAGERETDSGREDGTPR-----ERRPGRNTGKDTFGVPSSIEQHVTYH 190

Human   196 DLTDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHP 260
            ...|:.|||::|||||||||||||.||||||||||||||||||||||:||||:||||||||||||
Zfish   191 TTGDDASRLYMKKTIVVGNVSKYIAPDKREENDQSTHKWMVYVRGSRKEPSIDHFVKKVWFFLHP 255

Human   261 SYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVV 325
            ||||||||||.|||||||||||||||||||:||||.:||||||||:|||||||||||||||||||
Zfish   256 SYKPNDLVEVSEPPFHLTRRGWGEFPVRVQIHFKDQRNKRIDIIHHLKLDRTYTGLQTLGAETVV 320

Human   326 DVELHRHSLGEDCIYPQSSESDISDAPP-------SLPLTIPAPVKASSPIKQSHEPVPDTSVEK 383
            ||:|:|:|||:|.|....|.|..|.:.|       |...||....:.|||...:|:   |....:
Zfish   321 DVQLYRNSLGDDFIPSAPSSSSSSSSYPAFVGGSGSSSSTIHGSRRNSSPSHPAHD---DQHSSE 382

Human   384 AGFPASTEAERHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPN-PE 447
            .|....:|:.|       ||.||:| ::...|:|:|..||||||||||.|||||:||.|||: .|
Zfish   383 RGVTVKSESVR-------PSCLEQT-SQSNRSEKITLGSHGNSAFQPITSSCKIIPQGQVPSAAE 439

Human   448 SPGK-SFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVI 511
            |||| |||||||||||||||||||||.||||||.:|||||:|  ::.|||||||:|:|| |||||
Zfish   440 SPGKSSFQPITMSCKIVSGSPISTPSHSPLPRTSSSTPVHMK--SSPSVINNPYIIVDK-PGQVI 501

Human   512 ---GATTPSTGSPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPK 573
               .:::.:||||....|||    .|..||.||:|.|||::|.|
Zfish   502 NMAASSSAATGSPAKHSSTA----HGARSPAPKVHTSSFLSSGV--------------------- 541

Human   574 VQSPKPITGGLGAFTKVIIKQEPGEAPHVP-------ATGAASQSPLPQYVTVKGGHMIAVSPQK 631
                           ||||||||||.|..|       :|.|:.|.  .||||||||||||:||||
Zfish   542 ---------------KVIIKQEPGEVPTQPSPQQQVVSTSASQQQ--QQYVTVKGGHMIAMSPQK 589

Human   632 QVITPGEGIAQSAKVQPSKVVGVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQ 696
            |......|:|     .||||:|:|:|||    ||| |::|.|||||||:|.||||.||.||||.|
Zfish   590 QSGGGAGGVA-----TPSKVLGIPLGSA----VKQ-VSMSSGQILVAKSSPSVSKVVGQKQVVAQ 644

Human   697 GVAKAIVSGGG-GT--IVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGT 758
            ||||||||||| ||  :|.|.|...|||...:.|..|||    |||||||||.||||||||||||
Zfish   645 GVAKAIVSGGGSGTSGVVGQQVHVGTKAASGSGGGGKSG----VMATLQLPANNLANLANLPPGT 705

Human   759 KLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGS 823
            ||||||||||||||||||||||||||||:::|..||.|:.||||.:          .|||.|.||
Zfish   706 KLYLTTNSKNPSGKGKLLLIPQGAILRASHSAGQQSQSSGSGGSHS----------SSGSSGSGS 760

Human   824 TGGGGGTAGGGTQSTAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLG 888
                                :..:|:|||||||||||||||||||.  .||||.:.|.
Zfish   761 --------------------LPSNLSYTSYILKQTPQGTFLVGQPG--GSGKQSSGGH------- 796

Human   889 VSTSSAQG-QQTLKVISGQKTTLFTQAAH----GGQASLMKISDSTLK--TVPATSQLSKPGTTM 946
            |::|.|.| ||.::|.:|||..:..|..:    |.|.|.:|:||.::|  |..|.|.|:|||||.
Zfish   797 VASSPASGTQQAIRVTAGQKAAILAQVCNKVVGGSQGSQVKLSDGSVKMVTAAAASHLNKPGTTT 861

Human   947 LRVAGGVITTATSPAVALSANGPAQQSE---------------------------------GMAP 978
            ||:.|||||..:|.....||...:|||.                                 ..|.
Zfish   862 LRMTGGVITATSSTPTTPSATPTSQQSAEATGGSSSQQLPQTAKAPPHHPVLVAANQAAVISAAK 926

Human   979 VSSSTVSSVTKTSGQQQVCVSQ---------------ATVGTCKAATPTVVSATSLVPTPNPISG 1028
            .:||..::.|.:|....|.|::               :.|...|:::|::|:|.||: ....:||
Zfish   927 SASSAANTKTASSAGAVVTVAKSVNMPLISLPKGAGPSAVSGAKSSSPSLVTAASLI-GGGTVSG 990

Human  1029 K--ATVSGLLKIHSSQSSPQQAVLTIP-SQLKPLSVNT-SGGVQTILMPVNKVVQSFS--TSKPP 1087
            |  ||:||:||:|.:|||.||.||||| :|||.|||.: |.|:|||||||.|||||.|  ||...
Zfish   991 KTAATISGMLKLHPAQSSSQQTVLTIPANQLKQLSVGSGSSGLQTILMPVGKVVQSGSKGTSSNN 1055

Human  1088 AILPVAAPTPVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTA----------------------- 1129
            :....||      |||..|:|:|||||.....:|.:...||:
Zfish  1056 STPSGAA------SSASTAIAQVKTEPGLVSSTCTTPVPQTSAPTSAAPASAPLPTAPTSTDAAA 1114

Human  1130 -VKTEESSELGNY-VIKIDHLETIQQLLTAVVKKIPLIT-AKSEDASCFSAKSVEQYYGWNIGKR 1191
             ||.|:..|...: :|..:|:|.:.|||||:|||.|||. .|:||:..|.|.||:|||.||||||
Zfish  1115 TVKVEQGLESTTHELINTEHIENMTQLLTAIVKKFPLIVPEKNEDSHPFCATSVDQYYSWNIGKR 1179

Human  1192 RAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLT 1256
            ||||.|||:.:|:|..::||:.||...|||.:||.:..|||..||||||||..|.:.|||||:||
Zfish  1180 RAAELQRAVAVRRVCADLLERTPRLQALTPARTKEVLRWCRLRGYTPPDPEPQRTEEDSIEDILT 1244

Human  1257 QIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEE--VDILSLSE--PVKINIKKEQEEKQE 1317
            ||||||||.|:.:..:.|.::||.||:..|.||:.|::  :||:|:.|  ..|:.||:||||.::
Zfish  1245 QIDSEPECSSTLTGCEELSQRLEQLQRILKAEPDEEDDELLDIISVKELDAGKVKIKQEQEEAEQ 1309

Human  1318 EVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGYQ 1382
            |.|||:...|.::.|.|..::||:|||.|.:.:||:|.|||.|||||.||..::|||::||..:.
Zfish  1310 EPKFYMGRCPSTQLIRDTAEQIGVTLQQVEVEKNVFAPVVEAMILKAVEQFSSEILRESLANAHG 1374

Human  1383 TASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ 1423
            .:..||.|:||:..|:|||||:||..|||||::|||:.:|:
Zfish  1375 KSQQNRTPREISAMNVHQAICSIPTCDFLTNRYMGIMVKDE 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YEATS2	NP_001338299.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..198		31/80 (39%)
		YEATS_YEATS2_like	208..331	CDD:341126	113/122 (93%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	259..261		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	282..284		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..487		17/20 (85%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..541		10/26 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..843		11/47 (23%)
		DUF5585	<869..>1119	CDD:465521	114/310 (37%)
yeats2	XP_002660941.4	None