Protein Alignment YEATS2 and yeats2

DIOPT Version :10

• Sequence 1: NP_001338299.1
• Gene: YEATS2 / 55689
• HGNCID: 25489
• Length: 1423
• Species: Homo sapiens
• Sequence 2: XP_012825478.1
• Gene: yeats2 / 100135359
• XenbaseID: XB-GENE-5865259
• Length: 1238
• Species: Xenopus tropicalis
• Alignment Length: 1441
• Identity: 779/1441 - (54%)
• Similarity: 946/1441 - (65%)
• Gaps: 240/1441 - (16%)

Human     1 MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVID 65
            ||||||:.::.||||||:||...||||||.|.:||||.:.|||:||||||..|:||||||:||||
 Frog     1 MSGIKRSSEDKDPDYEDISVVHQNKRHKAAETTARDATILKIESIIKEQFVTELKNKEHEVEVID 65

Human    66 QRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRA 130
            |||.|||||||||||||||||||||.|.|..||..:.|..|.|||:||||||||||:|||||||:
 Frog    66 QRLNEARRMMDKLRACIVANYYASAALNKNQEGPSSYDATVLNHPSIKKFLESPSRASSPANQRS 130

Human   131 ETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNA 195
            ||||..:||:||:..||:   |||  .::|.:...:|. ..||..||.:|.|    .::..:|..
 Frog   131 ETPSVANSETDSVYTHNE---DKD--GSLDAKGPAANK-ALRPEGNTVKDPS----INENTERQV 185

Human   196 DLTDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHP 260
            ..|::..|.||||||||||||||||||||||||||||||||||||||:||||:||||||||||||
 Frog   186 SRTEDGPRRFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRKEPSIDHFVKKVWFFLHP 250

Human   261 SYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVV 325
            ||||||||||.|||||||||||||||||||:||||||||||||||||||||||||||||||||||
 Frog   251 SYKPNDLVEVSEPPFHLTRRGWGEFPVRVQIHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVV 315

Human   326 DVELHRHSLGEDCIYPQSS-ESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKAGFPAS 389
            :||::|||||||.:..||| |...|:|      ::.:.||:|||.|.:||
 Frog   316 EVEIYRHSLGEDFLGSQSSNECAQSEA------SLLSHVKSSSPHKVAHE--------------- 359

Human   390 TEAERHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPN-PESPGKSF 453
             .|::...:|..||||||||||:  :|:::|...|::|||||.:|||||||.|..: .|||||||
 Frog   360 -SADKEPSYYPQPSSLERTPTKV--AQRLSFGIPGSTAFQPITASCKIVPQGQAASLAESPGKSF 421

Human   454 QPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPST 518
            ||||||||||||                                                    |
 Frog   422 QPITMSCKIVSG----------------------------------------------------T 434

Human   519 GSPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGG 583
            ||||:|.|:.||.:.||.|||||:||:||....:|||||:||:|||||||||.||.||||.:|||
 Frog   435 GSPTSKHSSTSQGASGTKSPVPKLHGTSFTPQNIKQEDSMFAAMPPLCPIGSQPKAQSPKTVTGG 499

Human   584 LGAFTKVIIKQEPGE----APHVPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSA 644
            |||||||||||||.|    ....|:|   ||.||.|.|||||.||:||||||.:.| .||
 Frog   500 LGAFTKVIIKQEPTEPTQQLQEAPST---SQPPLQQIVTVKGNHMVAVSPQKNLAT-SEG----- 555

Human   645 KVQPSKVVGVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGT 709
                |||||:|||:.:.:.:|.:|.||||||||||:|||::||||.||:|.||||||:||.|.|.
 Frog   556 ----SKVVGIPVGTTVQAAIKPSVTISGGQILVAKSSSSIAKAVGSKQIVAQGVAKAVVSSGSGN 616

Human   710 IVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGK 774
            :|||..|:::|||||:|..||:||||||||||||||:|:.|||||||||||||||||||||||||
 Frog   617 VVAQSSQSVSKAQVTSAVAQKAGSQGSVMATLQLPASNIPNLANLPPGTKLYLTTNSKNPSGKGK 681

Human   775 LLLIPQGAILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTA 839
            ||||||||||||.|.|:||||:::||||                               .|.||.
 Frog   682 LLLIPQGAILRAANTASLQSGASSSGGS-------------------------------STASTT 715

Human   840 GPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVIS 904
              .|:.||||||||||||||||||||||.|.|.||||.....:|||.:   .:||||.||||:.:
 Frog   716 --SGLPQHLTYTSYILKQTPQGTFLVGQQSQQASGKQAAANVIVQGNV---ATSAQGHQTLKLTT 775

Human   905 GQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGP 969
            |.|.||..| .|...|::.||||..:.:|  .||..|||||:|||||||||.:::...::|.|..
 Frog   776 GPKGTLVAQ-THSASAAVAKISDGAVTSV--QSQTQKPGTTLLRVAGGVITASSASLPSVSTNVS 837

Human   970 AQQSEGMAPVSSSTVSSVTKTSGQQQVC--VSQATVGTCKAAT-PTVVSATSLVPTPNPISGKAT 1031
            .||:..::..|::.||:..|:..||.:.  ....::||.|.|| ...||:|...||
 Frog   838 TQQAADVSSTSTTQVSASNKSISQQVMARIAHVKSLGTVKPATSAAAVSSTRTAPT--------- 893

Human  1032 VSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPT 1096
                    .:|||...||...|......| :|||
 Frog   894 --------LAQSSAASAVKMEPDMTSNAS-STSG------------------------------- 918

Human  1097 PVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKI---------------- 1145
                                ||.|       |.||||||.|.....:::
 Frog   919 --------------------PGSS-------TPVKTEESGESDPSSVRVVGQVECASLRARHNWT 956

Human  1146 DHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEIL 1210
            :||:..:|||||:|||:||:..||||.:.|.|.||||||.||||||||:|||||:||:|:||||:
 Frog   957 EHLQNFKQLLTAIVKKVPLLAEKSEDGNAFCATSVEQYYSWNIGKRRASEWQRAVTMKKMLQEII 1021

Human  1211 EKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLC 1275
            ||.|:|.::.|||||.|.||||.|||||||||||.:|.:||||||.:||:|....:|||:.|.||
 Frog  1022 EKQPKFSNVAPLKTKQIVHWCRIHGYTPPDPESLGSDKESIEDVLARIDNEAALQTSFSAPDILC 1086

Human  1276 RKLEDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIG 1340
            :|:|:|::..|:|.|.:.:||:||.:|..:::|||| .|.:|:.|.|:..:|..|||.|..|:||
 Frog  1087 QKMEELEKTFKKETEEDVDVDVLSANEEQRLHIKKE-SEAEEDAKLYMVTSPACEFIRDKAQEIG 1150

Human  1341 ITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGYQTASHNRIPKEITVSNIHQAICNI 1405
            :::|||.:..|:|.|.||:||||||||.|:|:||.||.|.||..||||.|:||||||||||||||
 Frog  1151 VSVQPVEVQDNIYTSAVEEMILKATEQFVSDVLRDALGVAYQMTSHNRAPQEITVSNIHQAICNI 1215

Human  1406 PFLDFLTNKHM 1416
            |..||||||||
 Frog  1216 PMFDFLTNKHM 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YEATS2	NP_001338299.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	117..198		34/80 (43%)
		YEATS_YEATS2_like	208..331	CDD:341126	116/122 (95%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	259..261		1/1 (100%)
		Histone H3K27cr binding. /evidence=ECO:0000269|PubMed:27103431, ECO:0007744|PDB:5IQL	282..284		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	466..487		0/20 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	514..541		14/26 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	795..843		8/47 (17%)
		DUF5585	<869..>1119	CDD:465521	76/252 (30%)
yeats2	XP_012825478.1	YEATS_YEATS2_like	198..321	CDD:341126	116/122 (95%)