DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment znrf3 and APE3

DIOPT Version :9

Sequence 1:	NP_001295484.1	Gene:	znrf3 / 556813	ZFINID:	ZDB-GENE-070705-263	Length:	866	Species:	Danio rerio
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	258	Identity:	52/258 - (20%)
Similarity:	90/258 - (34%)	Gaps:	77/258 - (29%)

- Green bases have known domain annotations that are detailed below.

Zfish   480 TVVHMAPASSSRLGDSGSTSGLSC-----------YHGHRSVCSGYLADCPGSDSSSSSGQCHCS 533
            |...::|.....:|.......|.|           .|..:.:.......||..|.|:.:|:
Yeast   164 TAFALSPPVDGFVGKLVEIPNLGCEEKDYASVVPPRHNEKQIALIERGKCPFGDKSNLAGK---- 224

Zfish   534 SSDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYVYRSKSPCRGSAGEAGAVFSAAPPADDTSAP 598
                            :|    |.:.:..|.:|   :||....|:.||         |...|.|.
Yeast   225 ----------------FG----FTAVVIYDNEP---KSKEGLHGTLGE---------PTKHTVAT 257

Zfish   599 VSGMIDCLQPPGGACYSSGDQL-SNCSLEPNCSNHSS-------VETRELTSTTSAGPLEGNVAE 655
            |           |..|..|.:| :|.:|..:.|.:.:       ::|:.:.:.|..|..:..||.
Yeast   258 V-----------GVPYKVGKKLIANIALNIDYSLYFAMDSYVEFIKTQNIIADTKHGDPDNIVAL 311

Zfish   656 RSH-NSVKPCGEQGVACN--CCFEVPKLNLERKSKEGEDRGRCR---WATEAQAVASSQNFYS 712
            .:| :||    |:|...|  ....:..||:.::....:...:.|   ||.|.:.:..| |||:
Yeast   312 GAHSDSV----EEGPGINDDGSGTISLLNVAKQLTHFKINNKVRFAWWAAEEEGLLGS-NFYA 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
znrf3	NP_001295484.1	zf-RING_2	265..306	CDD:290367
znrf3	NP_001295484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..811
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	52/258 (20%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045	31/166 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910