DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment znrf3 and ZNRF3

DIOPT Version :9

Sequence 1:	NP_001295484.1	Gene:	znrf3 / 556813	ZFINID:	ZDB-GENE-070705-263	Length:	866	Species:	Danio rerio
Sequence 2:	NP_001193927.1	Gene:	ZNRF3 / 84133	HGNCID:	18126	Length:	936	Species:	Homo sapiens

Alignment Length:	904	Identity:	562/904 - (62%)
Similarity:	648/904 - (71%)	Gaps:	94/904 - (10%)

- Green bases have known domain annotations that are detailed below.

Zfish    25 GSVLAKDTAFVEVVLFESSPNGDYTTYTTGLQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDL 89
            |:..||:|||||||||||||:||||||||||.|||||||||:|||||||||||||||||||||||
Human    51 GAARAKETAFVEVVLFESSPSGDYTTYTTGLTGRFSRAGATLSAEGEIVQMHPLGLCNNNDEEDL 115

Zfish    90 YEYGWVGVVKLEQPELDPS-CLTVLGKAKRAVQRGATAVIFDVSENPDAIDQLNQVSEDPLKRPV 153
            ||||||||||||||||||. |||||||||||||||||||||||||||:|||||||.|||||||||
Human   116 YEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPV 180

Zfish   154 VYVKGTDAVKLMNIVNKQKVARARIQHRPPR-PTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQR 217
            |||||.||:|||||||||||||||||||||| |||||||||||||||||||||||||:|||||||
Human   181 VYVKGADAIKLMNIVNKQKVARARIQHRPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQR 245

Zfish   218 RSQSSMNRMAIQALEKMETCKFKAKFKGQREASCGASDSVSSSSTSDCAICLEKYIDGEELRVIP 282
            |||:||||:|:||||||||.||.:|.||:||.||||.|::|||||||||||||||||||||||||
Human   246 RSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSSSTSDCAICLEKYIDGEELRVIP 310

Zfish   283 CAHRFHKKCVDPWLLQHHTCPHCRHNIIDQKKGNPGAVCLDPGNPVHGRQQRVVLPVHYPGRVHR 347
            |.||||:|||||||||||||||||||||:| ||||.|||::..|...||||||.|||||||||||
Human   311 CTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ-KGNPSAVCVETSNLSRGRQQRVTLPVHYPGRVHR 374

Zfish   348 AGQVTAYPTRTSMDPHGNPITVLTVDQHPEQGLY-PSQSSFIRGYPALHLDHTLNPHHCGLEHRG 411
            ...:.|||||||||.||||:|:||:|:|.||.|| |...::||.||.|||||:|..|.||||||
Human   375 TNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQSLYSPQTPAYIRSYPPLHLDHSLAAHRCGLEHR- 438

Zfish   412 PAYPQTHTFKRPKFHGRNFSRAACFSQYETMYQHYYFQGLTFPQPEGQ-PSNGLHKGHNRPFQP- 474
             ||...|.|:|||..||:||:|||||||||||||||||||::|:.||| |.:...:|..|.|.|
Human   439 -AYSPAHPFRRPKLSGRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQSPPSLAPRGPARAFPPS 502

Zfish   475 ---GLLYPTVVHMAPASSSRLGDSGSTSGLSCYHGHRSVCSGYLADCPGSD--SSSSSGQCHCSS 534
               .||:|||||:||.|..   :|||||..|||||||||||||||||||||  ||||||||||||
Human   503 GSGSLLFPTVVHVAPPSHL---ESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSS 564

Zfish   535 SDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYVYRSKSPCR-------GSAGEAGAV-FSAAPP 591
            |||::|||||||||||||||||||||||||||::|||:||||       ||:|...|: |..:||
Human   565 SDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRSPCRASEAGGSGSSGRGPALCFEGSPP 629

Zfish   592 ADDTSAPVSGMIDCLQPPGGACYSSGDQLSNCSLEPNCSNHSSVETRELTSTTSAGPLEGN--VA 654
            .::..|..|......:|..|....||||:|.||||.|.|::||:|.|...|:||...||.:  .|
Human   630 PEELPAVHSHGAGRGEPWPGPASPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVGLEASPGAA 694

Zfish   655 ERSHNSVKPCGEQGVACNCCFEVPKLNLERKSKEGEDRGRCRWAT----------------EAQA 703
            .....:.|. |.:..:|.||.|      .:.|..|...|....:|                |.|:
Human   695 PDLRRTWKG-GHELPSCACCCE------PQPSPAGPSAGAAGSSTLFLGPHLYEGSGPAGGEPQS 752

Zfish   704 VASSQNFYSVSTEQLPSPDHVSYDGLPCCFYTEMTVHR---GGANHYAEDCSVNIQYAQTDS--D 763
             .|||..|.:..:.||..|.|.|:|||||||.|..|.|   ||:..|.||.||::||..|:.  .
Human   753 -GSSQGLYGLHPDHLPRTDGVKYEGLPCCFYEEKQVARGGGGGSGCYTEDYSVSVQYTLTEEPPP 816

Zfish   764 GCMGQGCCELAQRIPIIPEDTDCELGL-----------------GPE---PQTSLLSSRLTTERE 808
            ||. .|..:|:|||||||||.||:|||                 ||:   |...|.::|    .|
Human   817 GCY-PGARDLSQRIPIIPEDVDCDLGLPSDCQGTHSLGSWGGTRGPDTPRPHRGLGATR----EE 876

Zfish   809 ERTSSEDTCDLFFTSGQCRGQVYQQP--QDEEARALFSSKCNAVSETQGSSTSSFDGSG 865
            ||.    .|        |:.:...:|  ..|||.|:.::..:|:.:||.|||::.:.:|
Human   877 ERA----LC--------CQARALLRPGCPPEEAGAVRANFPSALQDTQESSTTATEAAG 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
znrf3	NP_001295484.1	zf-RING_2	265..306	CDD:290367	38/40 (95%)
znrf3	NP_001295484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..811		8/40 (20%)
ZNRF3	NP_001193927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		zf-RING_2	293..334	CDD:290367	38/40 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	608..693		31/84 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..758		5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	849..875		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	892..936		11/32 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194341687
Domainoid	1	1.000	510	1.000	Domainoid score	I2629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H46592
Inparanoid	1	1.050	1025	1.000	Inparanoid score	I2202
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40703
OrthoDB	1	1.010	-	-		D114304at7742
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto46572
orthoMCL	1	0.900	-	-		OOG6_113589
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.340