DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment znrf3 and Znrf3

DIOPT Version :9

Sequence 1:	NP_001295484.1	Gene:	znrf3 / 556813	ZFINID:	ZDB-GENE-070705-263	Length:	866	Species:	Danio rerio
Sequence 2:	NP_001074393.1	Gene:	Znrf3 / 407821	MGIID:	3039616	Length:	913	Species:	Mus musculus

Alignment Length:	904	Identity:	553/904 - (61%)
Similarity:	629/904 - (69%)	Gaps:	112/904 - (12%)

- Green bases have known domain annotations that are detailed below.

Zfish    25 GSVLAKDTAFVEVVLFESSPNGDYTTYTTGLQGRFSRAGATISAEGEIVQMHPLGLCNNNDEEDL 89
            |:..||:|||||||||||||:|||||:||||.||||||||.:|||||||||||||||||||||||
Mouse    48 GAARAKETAFVEVVLFESSPSGDYTTHTTGLTGRFSRAGAMLSAEGEIVQMHPLGLCNNNDEEDL 112

Zfish    90 YEYGWVGVVKLEQPELDPS-CLTVLGKAKRAVQRGATAVIFDVSENPDAIDQLNQVSEDPLKRPV 153
            ||||||||||||||||||. |||||||||||||||||||||||||||:|||||||.|||||||||
Mouse   113 YEYGWVGVVKLEQPELDPKPCLTVLGKAKRAVQRGATAVIFDVSENPEAIDQLNQGSEDPLKRPV 177

Zfish   154 VYVKGTDAVKLMNIVNKQKVARARIQHRPPR-PTEYFDMGIFLAFFVVVSLVCLILLIKIKLKQR 217
            |||||.||:||||||||||||||||||.||| |||||||||||||||||||||||||:|||||||
Mouse   178 VYVKGADAIKLMNIVNKQKVARARIQHLPPRQPTEYFDMGIFLAFFVVVSLVCLILLVKIKLKQR 242

Zfish   218 RSQSSMNRMAIQALEKMETCKFKAKFKGQREASCGASDSVSSSSTSDCAICLEKYIDGEELRVIP 282
            |||:||||:|:||||||||.||.:|.||:||.||||.|::||.||||||||||||||||||||||
Mouse   243 RSQNSMNRLAVQALEKMETRKFNSKSKGRREGSCGALDTLSSGSTSDCAICLEKYIDGEELRVIP 307

Zfish   283 CAHRFHKKCVDPWLLQHHTCPHCRHNIIDQKKGNPGAVCLDPGNPVHGRQQRVVLPVHYPGRVHR 347
            |.||||:|||||||||||||||||||||:| ||||||||::..|...|||.||.|||||||||||
Mouse   308 CTHRFHRKCVDPWLLQHHTCPHCRHNIIEQ-KGNPGAVCVETSNLTRGRQPRVTLPVHYPGRVHR 371

Zfish   348 AGQVTAYPTRTSMDPHGNPITVLTVDQHPEQGLY-PSQSSFIRGYPALHLDHTLNPHHCGLEHRG 411
            ...:.|||||||||.||||:|:||:|:|.||.|| |...:::||||.|||||||.||.|.||||
Mouse   372 TNAIPAYPTRTSMDSHGNPVTLLTMDRHGEQNLYSPQTPTYVRGYPPLHLDHTLAPHRCSLEHR- 435

Zfish   412 PAYPQTHTFKRPKFHGRNFSRAACFSQYETMYQHYYFQGLTFPQPEGQ--PSNGLHKGHNRPFQP 474
             ||...|.|:||||..|:||:|||||||||||||||||||::|:.|||  || ...:|.:|.|.|
Mouse   436 -AYSPAHPFRRPKFSSRSFSKAACFSQYETMYQHYYFQGLSYPEQEGQTIPS-VTPRGQSRAFPP 498

Zfish   475 ----GLLYPTVVHMAPASSSRLGDSGSTSGLSCYHGHRSVCSGYLADCPGSDSSS-SSGQCHCSS 534
                .||:||:||:||.:..   :|||||..|||||||||||||||||||||||| |||||.|||
Mouse   499 SGASSLLFPTMVHVAPPTHV---ESGSTSSFSCYHGHRSVCSGYLADCPGSDSSSNSSGQCRCSS 560

Zfish   535 SDSMLDCTEVSNQGVYGSCSTFRSSLSSDYDPYVYRSKSPCRGSAGEAGAVFSAAPPADDTSAPV 599
            |||::|||||||||||||||||||||||||||::|||:.|.....|        :||.::..|..
Mouse   561 SDSVVDCTEVSNQGVYGSCSTFRSSLSSDYDPFIYRSRGPAVHLEG--------SPPPEELPAGH 617

Zfish   600 SGMIDCLQPPGGACYSSGDQLSNCSLEPNCSNHSSVETRELTSTTSAGPLEGNVAERSHNSVKP- 663
            |......:|..|....||||||.||||.|.|::||:|.|...|:||...||          |.|
Mouse   618 SQSAGRGEPWLGPASPSGDQLSTCSLEMNYSSNSSLEPRGPNSSTSEVGLE----------VSPG 672

Zfish   664 ----------CGEQGVACNCCFE----VPKLNLERKSKEG---------EDRGRCRWATEAQAVA 705
                      .|.:|.:|.||||    .|...:|..:...         ||   |...:....:.
Mouse   673 AALDLRRTWKGGPEGPSCACCFEPQPFPPGSGIETSAGGSSLFLGPRLLED---CNPPSGEPQLG 734

Zfish   706 SSQNFYSVSTEQLPSPDHVSYDGLPCCFYTEMTV-HRGGANH--YAEDCSVNIQYAQTDS--DGC 765
            |||..|.:.::..|..|.|.|:|||||||.|..| |..|..:  |.||.||::||..|:.  ..|
Mouse   735 SSQGLYGLHSDHYPRTDGVKYEGLPCCFYEEKQVAHSAGRGNGCYTEDYSVSVQYTLTEEPPPSC 799

Zfish   766 MGQGCCELAQRIPIIPEDTDCELGLGPEPQ--------------TSLLSSRL-----TTEREERT 811
            .. |..:|:|||||||||.||:|||   ||              .||...||     ||..||:
Mouse   800 YA-GPRDLSQRIPIIPEDVDCDLGL---PQDCHGMHNHSPWGGALSLDVPRLHWSLGTTREEEQ- 859

Zfish   812 SSEDTCDLFFTSGQCRGQVYQ---QP--QDEEARALFSSKCNAVSETQGSSTSSFDGSG 865
                        ..|    ||   ||  ..|||.|..:|..:|..:||.|...:.:.||
Mouse   860 ------------APC----YQAEVQPGCSPEEAGASRASLSSAPQDTQESHALAAEASG 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
znrf3	NP_001295484.1	zf-RING_2	265..306	CDD:290367	38/40 (95%)
znrf3	NP_001295484.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..811		11/39 (28%)
Znrf3	NP_001074393.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-RING_2	289..331	CDD:290367	39/41 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..669		28/85 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..913		18/65 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C193143738
Domainoid	1	1.000	491	1.000	Domainoid score	I2847
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H46592
Inparanoid	1	1.050	997	1.000	Inparanoid score	I2299
OMA	1	1.010	-	-		QHG40703
OrthoDB	1	1.010	-	-		D138786at33208
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto56871
orthoMCL	1	0.900	-	-		OOG6_113589
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.340