Protein Alignment RUFY2 and CG31064

DIOPT Version :10

• Sequence 1: NP_060457.4
• Gene: RUFY2 / 55680
• HGNCID: 19761
• Length: 641
• Species: Homo sapiens
• Sequence 2: NP_001287560.1
• Gene: CG31064 / 43277
• FlyBaseID: FBgn0051064
• Length: 877
• Species: Drosophila melanogaster
• Alignment Length: 653
• Identity: 271/653 - (41%)
• Similarity: 402/653 - (61%)
• Gaps: 87/653 - (13%)

Human    25 GGRRGM-LTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHC 88
            ||..|: :|..:   :|...:||:||:|:.||.:|.|:|.:|.:||.||||:.|||.||:|:||.
  Fly   263 GGGGGLDITDNA---RDTAEIERSNLVNICKLVVKELLEQSLRYGRMLDSDHLPLQHFFIVIEHV 324

Human    89 LKHGLKVRKSFLSYNKTIWGPLELVEKLYPEAEEIGASVRDLPGLKTPLGRARAWLRLALMQKKM 153
            |.|||:.:|..|...|.:|..|:.||...|||::|.|||||||.::|.:||||||||:||||||:
  Fly   325 LGHGLRPKKGLLGPRKELWDLLQSVEHYCPEAQDITASVRDLPTVRTHIGRARAWLRIALMQKKL 389

Human   154 ADYLRCLIIQR-DLLSEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLDSQVGVIDFSM 217
            :|||:.||..| |.|.::||.|||||.:|..||:|:||||||||.|||||.||||||.||||||:
  Fly   390 SDYLQALIEHREDSLFDYYEPHALMMSDEIVVIMGILVGLNVIDCNLCVKEEDLDSQQGVIDFSL 454

Human   218 YLKNEEDIGNKERNVQIA-------------------AILDQKNYVEELNRQLNSTVSSLHSRVD 263
            ||:      :..||...|                   |:||||||:|||||.||:||.:|.::|:
  Fly   455 YLR------SSSRNADAAPEDSAPPALLDATGQGNMIAVLDQKNYIEELNRHLNATVGNLQAKVE 513

Human   264 SLEKSNTKLIEELAIAKNNIIKLQEENHQLRSENKLILMKTQQHLEVTKVDVETELQTYKHSRQG 328
            ||..:|..:.|:||||:|:::.||.||..:|.                    .|.......:..|
  Fly   514 SLTTTNALMKEDLAIARNSLLALQAENQAMRQ--------------------STSAGDNNSTGSG 558

Human   329 --LDEMYNEARRQLRDESQLRQDVENELAVQVSMKHEIELAMKLLEKDIHEKQDTLIGLRQQLEE 391
              .|:...:|..:|.:|.:...::|.||.:|||:|.|.::|||||||||||||||::.||:||::
  Fly   559 GSSDKDKEKASEELVEERRKNSELEKELKLQVSLKAESDMAMKLLEKDIHEKQDTIVSLRRQLDD 623

Human   392 VKAINIEMYQKLQGSEDGLKEKNEIIARLEEKTNKITAAMRQLEQRLQQAEKAQMEAEDEDEKYL 456
            :|.||:|||:|||..:..|..|.|::.:||.:...:.:.:.|||::.           ..|:..|
  Fly   624 IKQINLEMYRKLQDCKASLTHKTELMTKLEVQKEDMASTIDQLEKKW-----------SHDKSNL 677

Human   457 QECL-SKSDSLQKQISQKEKQLVQLETDLKIEKEWRQTLQEDLQKEKDALSHLRNETQQIISLKK 520
            .|.| :.|.:|..|::..|::..:.|.:.:||:|||.:|||...|.|:.:::|:...:::...|:
  Fly   678 GEILKTTSQTLTTQVTASEERAARAEAESRIEREWRISLQEKELKLKEKIANLQGCLKELSEEKE 742

Human   521 EFLNLQDENQQLKKIYHEQEQALQELGNKLSESKLKIEDIKEANK-----------ALQGL---- 570
            ....|:.:..:::..:.|.:..|:|||.:||.||||:.::::..:           :||.:
  Fly   743 RNGKLKADLDKVRTQWSEAQTTLEELGIQLSVSKLKVSEMQDQERRQRQLLSGSAQSLQAMPEAV 807

Human   571 ----VWLKDKEATHCKLCEKEFSLSKRKHHCRNCGEIFCNACSDNELPLPSSP----KPVRVCDS 627
                :|..|..||||..||:||:|::||||||:||||||.|||::.|||.::.    |||||||:
  Fly   808 GSPGIWAPDSIATHCTACEREFNLTRRKHHCRSCGEIFCKACSEHTLPLLNAQGQPGKPVRVCDN 872

Human   628 CHA 630
            |:|
  Fly   873 CYA 875

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RUFY2	NP_060457.4	RUN_RUFY2	45..200	CDD:439057	90/155 (58%)
		Smc	<301..>570	CDD:440809	85/282 (30%)
		FYVE_RUFY2	569..639	CDD:277298	38/74 (51%)
CG31064	NP_001287560.1	RUN_RUFY1_like	281..436	CDD:439043	89/154 (58%)
		Smc	<562..>807	CDD:440809	83/255 (33%)
		FYVE_RUFY1_like	813..874	CDD:277261	36/60 (60%)