Protein Alignment PRKACG and Pka-C1

DIOPT Version :9

• Sequence 1: NP_002723.2
• Gene: PRKACG / 5568
• HGNCID: 9382
• Length: 351
• Species: Homo sapiens
• Sequence 2: NP_476977.1
• Gene: Pka-C1 / 34284
• FlyBaseID: FBgn0000273
• Length: 353
• Species: Drosophila melanogaster
• Alignment Length: 353
• Identity: 263/353 - (74%)
• Similarity: 303/353 - (85%)
• Gaps: 2/353 - (0%)

Human     1 MGN--APAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRH 63
            |||  ..:.|..:..|:|.|||.:|:.:|..:|.....|||:.|.|||::|||.|||||||:|:|
  Fly     1 MGNNATTSNKKVDAAETVKEFLEQAKEEFEDKWRRNPTNTAALDDFERIKTLGTGSFGRVMIVQH 65

Human    64 QETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGE 128
            :.|..:||||||:||||||:|||||.||||||||||.|||||.|::.|||||.||:|:|||||||
  Fly    66 KPTKDYYAMKILDKQKVVKLKQVEHTLNEKRILQAIQFPFLVSLRYHFKDNSNLYMVLEYVPGGE 130

Human   129 MFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVK 193
            |||.|::||||||||:.|||||:|||.:|||.||||:|||||||||||.||||:|||||||||||
  Fly   131 MFSHLRKVGRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDSQGYLKVTDFGFAKRVK 195

Human   194 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRF 258
            |||||||||||||||||||||||||||||||||||:||||.|:|||:||||||||||||||:|||
  Fly   196 GRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLVYEMAAGYPPFFADQPIQIYEKIVSGKVRF 260

Human   259 PSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPG 323
            ||...||||.|||:|||||||||:|||:.||.||||.||||:|.||||::||:||||||:..|||
  Fly   261 PSHFGSDLKDLLRNLLQVDLTKRYGNLKAGVNDIKNQKWFASTDWIAIFQKKIEAPFIPRCKGPG 325

Human   324 DASNFDDYEEEELRISINEKCAKEFSEF 351
            |.|||||||||.||||..|||||||:||
  Fly   326 DTSNFDDYEEEALRISSTEKCAKEFAEF 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKACG	NP_002723.2	PTZ00426	36..351	CDD:173616	249/314 (79%)
		STKc_PKA	42..331	CDD:271111	230/288 (80%)
Pka-C1	NP_476977.1	STKc_PKA	44..333	CDD:271111	230/288 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7475
eggNOG	1	0.900	-	-		E1_KOG0616
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	605	1.000	Inparanoid score	I939
Isobase	1	0.950	-	0	Normalized mean entropy	S234
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D277423at33208
OrthoFinder	1	1.000	-	-		FOG0000539
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100326
Panther	1	1.100	-	-	O	PTHR24353
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X747
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780