DRSC/TRiP Functional Genomics Resources

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Protein Alignment MFN1 and shi

DIOPT Version :9

Sequence 1:NP_284941.2 Gene:MFN1 / 55669 HGNCID:18262 Length:741 Species:Homo sapiens
Sequence 2:NP_001259588.1 Gene:shi / 45928 FlyBaseID:FBgn0003392 Length:896 Species:Drosophila melanogaster


Alignment Length:836 Identity:143/836 - (17%)
Similarity:273/836 - (32%) Gaps:276/836 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    61 KDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAY- 124
            :|..:.:|..:.....::|..|..|:|||||:...:....||.|.|.:|...|.::..:|...| 
  Fly    12 QDAFTSLGVHMQLDLPQIAVVGGQSAGKSSVLENFVGKDFLPRGSGIVTRRPLILQLINGVTEYG 76

Human   125 --LMTEGSDEKKSVKTVNQLAHALHMDKDLKAG---------CLVRVFWPKAKCALLRDDLVLVD 178
              |..:|    |...:.:::...:..:.|...|         ..:||:.|...      :|.|:|
  Fly    77 EFLHIKG----KKFSSFDEIRKEIEDETDRVTGSNKGISNIPINLRVYSPHVL------NLTLID 131

Human   179 SPG----------TDVTTELDSWIDKFCLDADVFVLVANSEST-LMNTEKHFFHKVNERLSKPNI 232
            .||          .|:..::...|.:|.......:|.....:| |.|::.....|..:......|
  Fly   132 LPGLTKVAIGDQPVDIEQQIKQMIFQFIRKETCLILAVTPANTDLANSDALKLAKEVDPQGVRTI 196

Human   233 FILN--NRWDASASEPEYMED------------VRRQHMERCLHFLVEELKVVNALEAQNRIFFV 283
            .::.  :..|......:.:|:            |.|...:      :|..|.::...|..|.||:
  Fly   197 GVITKLDLMDEGTDARDILENKLLPLRRGYIGVVNRSQKD------IEGRKDIHQALAAERKFFL 255

Human   284 S---------------------------AKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFE 321
            |                           .::.|...:.|.|   :..:.|.:    .::||::|:
  Fly   256 SHPSYRHMADRLGTPYLQRVLNQQLTNHIRDTLPGLRDKLQ---KQMLTLEK----EVEEFKHFQ 313

Human   322 QIFEECISQSAVKTK------------FEQHTIRAKQILATVKNIMD--SVNLAAEDKRHYSV-- 370
            .      ..:::|||            ||:....:...|.....:..  .:|....::..:.:  
  Fly   314 P------GDASIKTKAMLQMIQQLQSDFERTIEGSGSALVNTNELSGGAKINRIFHERLRFEIVK 372

Human   371 ---EEREDQIDRLDFIRN----QMNLLTLD------VKKKIKEVTEEVANKVSCAMTDEICRLSV 422
               :|:|.:.:....|||    ::.|.|.|      ||::|..:.|.|...|...:.:    |||
  Fly   373 MACDEKELRREISFAIRNIHGIRVGLFTPDMAFEAIVKRQIALLKEPVIKCVDLVVQE----LSV 433

Human   423 LVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPLLPAG 487
            :|....::....|.:.:..:..:..|:     |.....|.:::..|:                  
  Fly   434 VVRMCTAKMSRYPRLREETERIITTHV-----RQREHSCKEQILLLI------------------ 475

Human   488 IQDKLHTLIPCKKFDLSY-NLNYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQR-------- 543
                        .|:|:| |.|:        ||               |:|..|||.        
  Fly   476 ------------DFELAYMNTNH--------ED---------------FIGFANAQNKSENANKT 505

Human   544 -------------------------VLLGLSEPI---FQLPRSLASTP-----TAPTTPATPDNA 575
                                     :.||.|.|:   |..|.:..|.|     |:.:.....|..
  Fly   506 GTRQLGNQVIRKGHMVIQNLGIMKDIKLGRSGPLNVRFFSPSTGGSRPYWFVLTSESISWYKDED 570

Human   576 SQEELMITLVTGL---------ASVTSRTSMGIIIVGG-VIWKTIGWKLLSVSLTMYGALYLYER 630
            .:|:..:..:.||         .|::.|.:..:....| .::|.                |....
  Fly   571 EKEKKFMLPLDGLKLRDIEQGFMSMSRRVTFALFSPDGRNVYKD----------------YKQLE 619

Human   631 LSWTTHAKERAFKQQFV-------NYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDITQ 688
            ||..|.....::|..|:       ...|::.....:|..::...|:::|:.|....:...:.|..
  Fly   620 LSCETVEDVESWKASFLRAGVYPEKQETQENGDESASEESSSDPQLERQVETIRNLVDSYMKIVT 684

Human   689 KQLEEEIARLPKEIDQLEKIQNNSKLLRN------------KAVQLENELENFTKQ 732
            |...:.:   ||.|..|  |.||:|...|            :|..:|...|:.|::
  Fly   685 KTTRDMV---PKAIMML--IINNAKDFINGELLAHLYASGDQAQMMEESAESATRR 735

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
MFN1NP_284941.2 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000269|PubMed:16959974, ECO:0000269|PubMed:28114303 9..73 2/11 (18%)
DLP_2 76..328 CDD:206739 56/315 (18%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 82..89 3/6 (50%)