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Protein Alignment MFN1 and fzo

DIOPT Version :10

Sequence 1:	NP_284941.2	Gene:	MFN1 / 55669	HGNCID:	18262	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_732840.1	Gene:	fzo / 42745	FlyBaseID:	FBgn0011596	Length:	718	Species:	Drosophila melanogaster

Alignment Length:	758	Identity:	254/758 - (33%)
Similarity:	399/758 - (52%)	Gaps:	88/758 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     6 SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEAT--YKNPELDRIATEDDLVEMQGYKDKLSIIG 68
            |.|..||.||..:..|:..|..:::.....:|.|  .|:.::        |..:..:..::..|.
  Fly    23 SRLSEFVDAKTELQDIYHDLSNYLSNFLTILEETVLLKDRQM--------LEHLCAFSSRVEAIA 79

Human    69 EVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKA-YLMTEGSDE 132
            :||||..||||||||||:|||:||||:|.:|:|||.:||.|:||..|:....::. ::..|..||
  Fly    80 KVLSRDRMKVAFFGRTSNGKSAVINALLHEKILPSAMGHTTSCFCQVQANGSNETEHVKVEQEDE 144

Human   133 KKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCL 197
            ...:..::|||.| |....||...|::|...|.:|::|..|:||:|:||.|||.:||..:|.:|:
  Fly   145 HMELSALSQLASA-HSPGALKPSTLLQVNMAKNRCSILDYDVVLMDTPGVDVTAQLDDCLDSYCM 208

Human   198 DADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWD-ASASEPEYMEDVRRQHMERCL 261
            |||||:||.|:|||:...|:.||..|..:||:||:|||||||| ||:.|||..:.|:.||||||:
  Fly   209 DADVFILVLNAESTVSRVERQFFKDVASKLSRPNLFILNNRWDKASSLEPEMEQKVKDQHMERCV 273

Human   262 HFLVEELKVVN-ALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFE 325
            :.||:||.|.: |.||..||:.|||.|.|..|  ..|....||..     ..|.|||..||..|.
  Fly   274 NLLVDELGVYSTAQEAWERIYHVSALEALHIR--NGQITNPSGQT-----QQRYQEFLRFENDFS 331

Human   326 ECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDF-IRNQMNL 389
            .|::.||:||||..|.:.|::||..:|:.:....:   :|....::|.:::...|:. |.:.:.|
  Fly   332 NCLAVSALKTKFGPHLLSAQKILNQLKSTLICPFI---EKVSRLIDENKERRANLNAEIEDWLIL 393

Human   390 LTLDVK------KKIKEVTEEVANKVSCAMTDEICRL---SVLVDEFCSEFHPN-PDVLKIYKSE 444
            :..|.:      :::.|:|:.|..   |.:.|:|..|   |||  .|...|||. |..:..|:..
  Fly   394 MQEDREALQYCFEELTEMTQRVGR---CVLNDQIKTLIPSSVL--SFSQPFHPEFPAQIGQYQRS 453

Human   445 LNKHIEDGMGRNLADRCTDEVNALVLQTQQEIIENLKPL-LPAGIQDKLHTLIPCKKFDLSYNLN 508
            |..|::    :.|.||.   :..|.:..|::|::..|.: ||.....       | .:.|.|.|:
  Fly   454 LCAHLD----KLLEDRV---LQCLSIPLQRKILDIEKEIGLPIAENS-------C-DWQLIYGLD 503

Human   509 YHKLCSDFQEDIVFRFSLGWSSLVHRFLG-------PRNAQRVLLGLSEPIFQLPRSLASTPTAP 566
            .....||||.|:.||||||:::|.||..|       |...|::..|..:             .:|
  Fly   504 CQSYMSDFQPDLRFRFSLGFTALWHRLEGNLPLHASPFRIQKLQNGHKK-------------CSP 555

Human   567 TTPATPDNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMYGALYLYERL 631
            ..|..  |.:..:::.:|      |.|:.|:|.:::..:..::..|.::.:...:.|:.|:||..
  Fly   556 LPPLV--NGNHWQMLESL------VKSKGSLGTVLLSAMAIRSFNWPIVLILGGLVGSFYIYEYA 612

Human   632 SWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLC--QQVDITQKQLEEE 694
            :|||.|:||:||.|:.....::||..|..|.:....|::|.:||  .|.|  .|.:.|...|...
  Fly   613 AWTTAAQERSFKSQYARLLQQRLRSDVQQTVSGFELQLRQHLAT--VRNCWEAQSNETLNDLNVR 675

Human   695 IARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFLPSS 737
            .|.|.|:|..:|.:|.:.|..|:|...|.:.|.:|.:.:|..|
  Fly   676 TAELTKQIQSMEVLQLSLKKFRDKGQLLASRLGDFQETYLTKS 718

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.