DRSC/TRiP Functional Genomics Resources

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Protein Alignment MFN1 and Opa1

DIOPT Version :9

Sequence 1:NP_284941.2 Gene:MFN1 / 55669 HGNCID:18262 Length:741 Species:Homo sapiens
Sequence 2:NP_725369.1 Gene:Opa1 / 36578 FlyBaseID:FBgn0261276 Length:972 Species:Drosophila melanogaster


Alignment Length:823 Identity:167/823 - (20%)
Similarity:275/823 - (33%) Gaps:270/823 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    54 LVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGH-ITNCFLSV-- 115
            |.|:.||.     .|..::....:|...|..||||:||:.::...::.|.|.|. :|...:.|  
  Fly   283 LDELSGYD-----TGYTMADHLPRVVVVGDQSSGKTSVLESIAKARIFPRGSGEMMTRAPVKVTL 342

Human   116 -EG-------TDGDKAYLMTEGSD-----------EKKSV---KTVNQLAHALHMDKDLKAGCLV 158
             ||       .|.|:.|.:|:.||           .|.||   |||:....|:    .:|...|.
  Fly   343 AEGPYHVAQFRDSDREYDLTKESDLQDLRRDVEFRMKASVRGGKTVSNEVIAM----TVKGPGLQ 403

Human   159 RVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKV 223
            |              :||||.||...|..:|              :.::::.::....||:    
  Fly   404 R--------------MVLVDLPGIISTMTVD--------------MASDTKDSIHQMTKHY---- 436

Human   224 NERLSKPNIFILNNRWDASASEPEYMEDVRRQ--HMERCLHFLVEELKVVNALEAQNRIFFVSAK 286
               :|.||..||..:..:..:|...:.|:..|  .:.|...|::.::.:...|...:||     :
  Fly   437 ---MSNPNAIILCIQDGSVDAERSNVTDLVMQCDPLGRRTIFVLTKVDLAEELADPDRI-----R 493

Human   287 EVLSAR--KQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILA 349
            ::||.:  ..||.|.    .|:..|...:........|..|:....|  |....:..|...|:  
  Fly   494 KILSGKLFPMKALGY----YAVVTGRGRKDDSIDAIRQYEEDFFKNS--KLFHRRGVIMPHQV-- 550

Human   350 TVKNIMDSVNLAAEDKRHYSVEER-EDQIDRLDFIRNQMNLLTLDVKKKIKEVTE----EVANKV 409
            |.:|:    :||..|:....|.|. |.|.|.  |...:.||.| :.|.....:.|    |:.:|.
  Fly   551 TSRNL----SLAVSDRFWKMVRETIEQQADA--FKATRFNLET-EWKNNFPRLRESGRDELFDKA 608

Human   410 SCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNALVLQTQQ 474
            ...:.||:..||.:                     ..|..:|.:...|.::.::.|         
  Fly   609 KGEILDEVVTLSQI---------------------SAKKWDDALSTKLWEKLSNYV--------- 643

Human   475 EIIENL-KPLLPAGIQDKLHTLIPCKKFDLSYNLNYHKLCSDFQEDIVFRFSL--GWSSLVHRFL 536
              .|:: .|...:|.|:..:|::..|             ...:.|..:...|:  ||.:|...|:
  Fly   644 --FESIYLPAAQSGSQNSFNTMVDIK-------------LRQWAEQALPAKSVEAGWEALQQEFI 693

Human   537 G----PRNAQRVLLGLSEPIFQLPRSLASTPTAPTTPATPDNA----SQEELMITLVTGLASVTS 593
            .    .:.||.     .:.||...:|           |..|.|    |.|:..|.:   |..:..
  Fly   694 SLMERSKKAQD-----HDGIFDQLKS-----------AVVDEAIRRHSWEDKAIDM---LRVIQL 739

Human   594 RTSMGIIIVGGVIW--------KTIGWKLLSVSLT---MYGA---------LYL----------- 627
            .|.....:.....|        .::..||:....|   |:|.         .||           
  Fly   740 NTLEDRFVHDKQEWDSAVKFLESSVNAKLVQTEETLAQMFGPGQMRRITHWQYLTQDQQKRRSVK 804

Human   628 ---------------------------------------YERLSWTTHAKERAFKQQFVNYATE- 652
                                                   |.|.:|.. ...:.|.||.:..|.: 
  Fly   805 NELDKILKNDTKHLPTLTHDELTTVRKNLQRDNVDVDTDYIRQTWFP-VYRKHFLQQALQRAKDC 868

Human   653 -KLRMIVSSTSANCSHQVKQQIATTFARLCQQVDIT-----QKQLEEEIARLPKEI--------D 703
             |...:.:...|.|  ::.......|.|:.|.:.||     |:.:..|..||.|||        |
  Fly   869 RKAYYLYTQQGAEC--EISCSDVVLFWRIQQVIKITGNALRQQVINREARRLDKEIKAVLDEFSD 931

Human   704 QLEKIQNNSKLLRNKAVQLENEL------ENFTKQFLPSSNEE 740
            ..||   ...||..|.|.|..||      :...::|:.|.|:|
  Fly   932 DEEK---KGYLLTGKRVLLAEELIKVRQIQEKLEEFINSLNQE 971

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
MFN1NP_284941.2 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000269|PubMed:16959974, ECO:0000269|PubMed:28114303 9..73 5/18 (28%)
DLP_2 76..328 CDD:206739 63/280 (23%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 82..89 4/6 (67%)