DRSC/TRiP Functional Genomics Resources

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Protein Alignment MFN1 and Drp1

DIOPT Version :9

Sequence 1:NP_284941.2 Gene:MFN1 / 55669 HGNCID:18262 Length:741 Species:Homo sapiens
Sequence 2:NP_001259946.1 Gene:Drp1 / 33445 FlyBaseID:FBgn0026479 Length:735 Species:Drosophila melanogaster


Alignment Length:634 Identity:112/634 - (17%)
Similarity:208/634 - (32%) Gaps:190/634 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    77 KVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITN-------CFLSVEGTDGDKAYLMTEGSDE-- 132
            ::...|..||||||||.:::....||.|.|.:|.       .:..::..:...|...|..::|  
  Fly    27 QIVVLGSQSSGKSSVIESVVGRSFLPRGTGIVTRRPLVLQLIYSPLDDRENRSAENGTSNAEEWG 91

Human   133 -----KKSVKTVNQLAHALHMDKDLKAG-----C----LVRVFWPKAKCALLRDDLVLVDSPG-- 181
                 ||.....:::...:..:.:..||     |    .:::|.....      :|.|||.||  
  Fly    92 RFLHTKKCFTDFDEIRKEIENETERAAGSNKGICPEPINLKIFSTHVV------NLTLVDLPGIT 150

Human   182 --------TDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKP-------- 230
                    .|:..::...:.|:..:.:..:|...:.:|.|.|.:..      :|:|.        
  Fly   151 KVPVGDQPEDIEAQIKELVLKYIENPNSIILAVTAANTDMATSEAL------KLAKDVDPDGRRT 209

Human   231 -----------------------------NIFILNNRWDASASEPEYMEDVRRQH---MERCLHF 263
                                         .|..:.||......:.::::|..:..   ::|....
  Fly   210 LAVVTKLDLMDAGTDAIDILCGRVIPVKLGIIGVMNRSQKDIMDQKHIDDQMKDEAAFLQRKYPT 274

Human   264 LVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECI 328
            |..........:..||:.....::.|...|.:...|              ..:||:....:.|.:
  Fly   275 LATRNGTPYLAKTLNRLLMHHIRDCLPDLKTRVNIM--------------ATQFQSLLNSYGEDV 325

Human   329 SQSA-----VKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMN 388
            |..:     :.|||.  :.....|..|.:|| ::..|....:..|...|...:  .||.|.....
  Fly   326 SDKSQTLLQIITKFS--SAYCCTIEGTARNI-ETTELCGGARMGYIFHETFGR--TLDSIHPLAG 385

Human   389 LLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELN--KHIED 451
            |..:|:...|:..|..              |.::.|.|...|......:.::.:..|.  :.|.:
  Fly   386 LSKMDILTAIRNATGP--------------RPALFVPEVSFELLVKRQIRRLEEPSLRCVELIHE 436

Human   452 GMGRNLADRCTDEVNALVL---QTQQEIIENLKPLLPAGIQDKLHTLIPCKK---FDLSYNLNYH 510
            .|.| :...|.:||...:|   :..::|::.:..||...:.   ||.:..:.   .:|:|....|
  Fly   437 EMQR-IVQHCGNEVQQEMLRFPKLHEKIVDVVTQLLRRRLP---HTNVMVENIVAIELAYINTKH 497

Human   511 KLCSDFQEDIVF-------------RFSLGWSSLVHRFLGPRNAQRVLL-----GLSEPIFQLP- 556
               .||.:|...             :.:||    ..|...|||.....:     |..:|..|.| 
  Fly   498 ---PDFHKDAALVPSLLKTDSDPYSQINLG----QRRANTPRNHMSPQISSHSAGSQQPQQQQPP 555

Human   557 -----------------------RSLAST------PTAPTTPATPDNAS 576
                                   .|:|||      |.|||.|.:.:|::
  Fly   556 QPNSSQQQYSQVHEQNHVAENSTPSMASTWLSNILPPAPTRPDSIENST 604

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
MFN1NP_284941.2 Part of a helix bundle domain, formed by helices from N-terminal and C-terminal regions. /evidence=ECO:0000269|PubMed:16959974, ECO:0000269|PubMed:28114303 9..73
DLP_2 76..328 CDD:206739 51/323 (16%)
G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01055 82..89 4/6 (67%)