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Protein Alignment MFN1 and Marf

DIOPT Version :10

Sequence 1:	NP_284941.2	Gene:	MFN1 / 55669	HGNCID:	18262	Length:	741	Species:	Homo sapiens
Sequence 2:	NP_572320.2	Gene:	Marf / 31581	FlyBaseID:	FBgn0029870	Length:	814	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	357/762 - (46%)
Similarity:	485/762 - (63%)	Gaps:	54/762 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     6 SPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEATYKNPEL-DRIATEDDLVEMQGYKDKLSIIGE 69
            |||:.||.|||.|..|:.::.|:|.|.:.|:.|.:...|: |:  .|.:|.|  .|..|::.|.|
  Fly    71 SPLQIFVRAKKKINDIYGEIEEYVHETTTFINALHAEAEIVDK--AERELFE--SYVYKVAAIRE 131

Human    70 VLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDKAYLMTEGSDEKK 134
            ||.|.|||||||||||:||||||||||.:|:|||||||.||||..|||::|.:||||||||:||.
  Fly   132 VLQRDHMKVAFFGRTSNGKSSVINAMLREKILPSGIGHTTNCFCQVEGSNGGEAYLMTEGSEEKL 196

Human   135 SVKTVNQLAHALHMDKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKFCLDA 199
            :|..:.|||:||..:| |....|||:|||:.:|:|||||:|.|||||.||:..||.|||..||:|
  Fly   197 NVVNIKQLANALCQEK-LCESSLVRIFWPRERCSLLRDDVVFVDSPGVDVSANLDDWIDNHCLNA 260

Human   200 DVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMED----VRRQHMERC 260
            ||||||.|:|||:...||.|||.|:::|||||||||||||||||:|||..|.    |:.||.|||
  Fly   261 DVFVLVLNAESTMTRAEKQFFHTVSQKLSKPNIFILNNRWDASANEPECQESELAKVKSQHTERC 325

Human   261 LHFLVEELKVVNALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFE 325
            :.||.:||||.|..||..|:|||||:|.|.||.::|:|.|....|:||||..|..|||:||:.||
  Fly   326 IDFLTKELKVSNEKEAAERVFFVSARETLQARIEEAKGNPPHMGAIAEGFQIRYFEFQDFERKFE 390

Human   326 ECISQSAVKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLL 390
            ||||||||||||:||:.|.|.:...:|:::|::.......|:...:::....:|:.....||..:
  Fly   391 ECISQSAVKTKFQQHSSRGKSVSGDMKSMLDNIYERITIFRNLKQDQKNLLTERIQGTETQMMQV 455

Human   391 TLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPNPDVLKIYKSELNKHIEDGMGR 455
            |.::|.||..:.|||..|||.|:.:||.||.||:|||...|||...||.|||.|||.|:|.|:|.
  Fly   456 TREMKMKIHNMVEEVEEKVSKALNEEIWRLGVLIDEFNMPFHPERLVLNIYKKELNAHVESGLGS 520

Human   456 NLADRCTDEVNALVLQTQQEIIENLKPLLPAGIQDKLHTLIP--------------CKKFDLSYN 506
            ||..|.:..:...|...|.|            :.|::|.|:|              .:.|::.|:
  Fly   521 NLRARLSMALAMNVESAQTE------------MTDRMHALVPNEQLLATSTKMVVRTQPFEMLYS 573

Human   507 LNYHKLCSDFQEDIVFRFSLGWSSLVHRFLG-----PRNAQRVLLGLSEPIFQLPRSLASTPTAP 566
            ||...||:|||||:.|:||.|.::::.||.|     .:..|..|:.....|    ....||||..
  Fly   574 LNCQNLCADFQEDLEFKFSWGIAAMIQRFTGKVRERSKKGQPALVNRQSSI----GHSVSTPTTT 634

Human   567 TTPATP---------DNASQEELMITLVTGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMY 622
            ...|||         ...:.|:|.:.....::|:.|:.::|.::|.||:.|||||::|.....:|
  Fly   635 PVEATPVCLLPAPVVAGITPEQLSLISRFAVSSIGSQGTVGGLVVAGVMLKTIGWRVLVGVGALY 699

Human   623 GALYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSANCSHQVKQQIATTFARLCQQVDIT 687
            |.:|||||||||..||||.||.|:|.:||:||:|||..|||||||||:|::::||||||:.||..
  Fly   700 GCIYLYERLSWTNSAKERTFKSQYVRHATKKLKMIVDLTSANCSHQVQQELSSTFARLCRTVDTA 764

Human   688 QKQLEEEIARLPKEIDQLEKIQNNSKLLRNKAVQLENELENFTKQFL 734
            ...:.:|:..|..:::.||..|...|||||||..::|||:.|...::
  Fly   765 TTDMNDELKTLDSQLNILEANQKQLKLLRNKANYIQNELDIFEHNYI 811

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.