Protein Alignment NPLOC4 and NPL4

DIOPT Version :10

• Sequence 1: NP_001424915.1
• Gene: NPLOC4 / 55666
• HGNCID: 18261
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_009729.1
• Gene: NPL4 / 852468
• SGDID: S000000374
• Length: 580
• Species: Saccharomyces cerevisiae
• Alignment Length: 591
• Identity: 204/591 - (34%)
• Similarity: 327/591 - (55%)
• Gaps: 50/591 - (8%)

Human     5 IIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGE----ITASSNKSLN 65
            ::||.:|.:|..|::..:.:...|.::|:..... .|.....:....|.|:    ::..:::::.
Yeast     1 MLIRFRSKNGTHRVSCQENDLFGTVIEKLVGNLD-PNADVDTFTVCEKPGQGIHAVSELADRTVM 64

Human    66 LLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKV----------------FGAPNVVEDEIDQYL 114
            .|.:||||:|.|..|.  .|::|.:     |..|                :|...:.|..:|:.|
Yeast    65 DLGLKHGDMLILNYSD--KPANEKD-----GVNVEIGSVGIDSKGIRQHRYGPLRIKELAVDEEL 122

Human   115 SKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADK-- 177
            .|:||.|.|.:. :||:||..|.|.:|.||.|:|::|  |.:..:||:|||:|::||...|:|
Yeast   123 EKEDGLIPRQKS-KLCKHGDRGMCEYCSPLPPWDKEY--HEKNKIKHISFHSYLKKLNENANKKE 184

Human   178 --GKFVA-LENISCKIKSGC-EGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFL 238
              ..::: |.....:|...| .||.|||.|||:|||||||||.:|::|.||::.|:...:.:.|:
Yeast   185 NGSSYISPLSEPDFRINKRCHNGHEPWPRGICSKCQPSAITLQQQEFRMVDHVEFQKSEIINEFI 249

Human   239 DFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLEL-LEDPKAEV--VDEIA 300
            ..||.||.|.|||:||.|:::.:.||||:|.|.|||||||...|:.|.: :|..|.|:  :|..|
Yeast   250 QAWRYTGMQRFGYMYGSYSKYDNTPLGIKAVVEAIYEPPQHDEQDGLTMDVEQVKNEMLQIDRQA 314

Human   301 AKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGS 365
            .::||.::|.|||||.......|:|...|:||::||||.|.|.|...|.:|||:.:.|..|.|.|
Yeast   315 QEMGLSRIGLIFTDLSDAGAGDGSVFCKRHKDSFFLSSLEVIMAARHQTRHPNVSKYSEQGFFSS 379

Human   366 KFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDVD 430
            ||||.|.:|..:.::....||||.:..|||..: ::.....|.:.|..:::.|:|||::||...:
Yeast   380 KFVTCVISGNLEGEIDISSYQVSTEAEALVTAD-MISGSTFPSMAYINDTTDERYVPEIFYMKSN 443

Human   431 KFGNEITQLARP-LPVEYLIIDITTTFPKDPVYTFS--ISQNPFPIENRDVLGETQDFHSLATYL 492
            ::|..:.:.|:| .||:||::.:|..||.....|.|  :|...||..||..:|::||:..|..||
Yeast   444 EYGITVKENAKPAFPVDYLLVTLTHGFPNTDTETNSKFVSSTGFPWSNRQAMGQSQDYQELKKYL 508

Human   493 SQNTSS----VFLDTISDFHLLLFLVTNEVMPLQDSISLLLE-AVRTRNEELAQTWKRSEQWATI 552
            ....||    :..:.||:|||||::.:.:::. .|...||:| ||:...||.......|..|.|:
Yeast   509 FNVASSGDFNLLHEKISNFHLLLYINSLQILS-PDEWKLLIESAVKNEWEESLLKLVSSAGWQTL 572

Human   553 EQLCSE 558
            ..:..|
Yeast   573 VMILQE 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPLOC4	NP_001424915.1	None
NPL4	NP_009729.1	NPL4	1..580	CDD:227431	204/591 (35%)