Protein Alignment NPLOC4 and Npl4

DIOPT Version :10

• Sequence 1: NP_001424915.1
• Gene: NPLOC4 / 55666
• HGNCID: 18261
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_651407.3
• Gene: Npl4 / 43091
• FlyBaseID: FBgn0039348
• Length: 652
• Species: Drosophila melanogaster
• Alignment Length: 579
• Identity: 285/579 - (49%)
• Similarity: 387/579 - (66%)
• Gaps: 41/579 - (7%)

Human     1 MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQN----NGFSVYINRNKTGEITASSN 61
            :.:..:|||||.:|:|||..:.:.........|      ||    :||.::..||...|:.||.:
  Fly    30 LCKQSLIRVQSAEGIKRIEISPKSNLKHLYDSV------QNALKVDGFGLFKERNFLTELQASGS 88

Human    62 KSLNLLKIKHGDLLFLFPSSLAGPSSEMET------------------SVPPGFKVFGAPNVVED 108
            :.:. ..::|||:::|  ..:||.||...:                  |..|.|      ||:||
  Fly    89 QLVG-TSLRHGDMVYL--KQMAGTSSRRTSTTVLDSQAFKTSTISNPNSARPSF------NVIED 144

Human   109 EIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTG 173
            ::||.|||.||.|.|.||.:||.|...|:||||..|||:||.||.  |..:||:|||:||||.|.
  Fly   145 DVDQALSKADGTIKRERDSKLCHHNANGRCVHCSALEPYDESYLK--EHNIKHLSFHSYIRKQTS 207

Human   174 GADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFL 238
            |.|:||:...::|:|:||.||..|.|||.|||:||||||||||||.||||||:||||..:.:|||
  Fly   208 GMDQGKYFVFDDINCRIKPGCREHPPWPKGICSKCQPSAITLNRQTYRHVDNVMFENTKIVERFL 272

Human   239 DFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKL 303
            ::||.||:|..|||||.|.:|.|:||||||:|||||||||..|::|:.:..|..|:.||.:|:.|
  Fly   273 NYWRTTGHQRMGYLYGTYEQHTDVPLGIRAKVAAIYEPPQESTRDSINIQPDEFADDVDAVASAL 337

Human   304 GLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGSKFV 368
            ||:|:|||||||:::|...|||:..|..:::|::::||||||:.||:|||.|:.:.:|.||||||
  Fly   338 GLKKIGWIFTDLITDDASIGTVKQIRGIESHFITAQECITAGELQNRHPNPCKYASNGVFGSKFV 402

Human   369 TAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDVDKFG 433
            |...||....|||.|||.||.||||||||.||:|.||||||||.:||:.:|||||||||:.|.:|
  Fly   403 TICVTGDKTKQVHMEGYAVSAQCMALVRDNCLIPTKDAPELGYVRESTDKQYVPDVFYKEKDLYG 467

Human   434 NEITQLARPLPVEYLIIDITTTFPKDPVYTFS--ISQNPFPIENRDVLGETQDFHSLATYLSQNT 496
            ||:.:||||||||||::|:..:.|..|:|||:  ..:.|||||||.:.|..|||::|:.|||...
  Fly   468 NEVQRLARPLPVEYLLVDVPASTPLQPIYTFTEYDKRQPFPIENRYIDGHLQDFNALSCYLSAWG 532

Human   497 SSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKRSEQWATIEQL 555
            ...||:.|||||||::|...:::||:..:..|||||||:|...|..:|..:.|..:|.|
  Fly   533 EEEFLEAISDFHLLVYLYKMDMLPLRQHMGPLLEAVRTKNPNQAAQFKVVDVWKLLESL 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPLOC4	NP_001424915.1	None
Npl4	NP_651407.3	UN_NPL4	35..105	CDD:431926	23/78 (29%)
		zf-NPL4	141..279	CDD:461523	84/139 (60%)
		NPL4	282..593	CDD:461524	167/310 (54%)
		ZnF_RBZ	627..651	CDD:197784
		RanBP2-type Zn finger	629..648	CDD:275376