Protein Alignment NPLOC4 and nploc4

DIOPT Version :10

• Sequence 1: NP_001424915.1
• Gene: NPLOC4 / 55666
• HGNCID: 18261
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_956101.1
• Gene: nploc4 / 327447
• ZFINID: ZDB-GENE-030131-5658
• Length: 624
• Species: Danio rerio
• Alignment Length: 607
• Identity: 486/607 - (80%)
• Similarity: 527/607 - (86%)
• Gaps: 32/607 - (5%)

Human     1 MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLN 65
            ||||||:|:|||||:|:|::||.||||.|||||||||||.:||||||:|||||||| .|.||:|:
Zfish     1 MAESIIVRIQSPDGMKKISSTKHETAAAFLKKVAKEFGFSSNGFSVYLNRNKTGEI-LSQNKALS 64

Human    66 LLKIKHGDLLFLFPSSLAGPSSE-METSVP------PGF-----------KVFGAPNVVEDEIDQ 112
            ||||||||:|||:||| |||||| |:|:.|      |.|           :...||.:.||:|||
Zfish    65 LLKIKHGDMLFLYPSS-AGPSSENMDTAQPHTSSSFPSFPSSSSSSSSLSRSHSAPQIPEDDIDQ 128

Human   113 YLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADK 177
            |||||:|||||:|||||||||.:||||||||||||||||||||:|||||||||||||||||||||
Zfish   129 YLSKQEGKIYRNRDPQLCRHGAMGKCVHCVPLEPFDEDYLNHLDPPVKHMSFHAYIRKLTGGADK 193

Human   178 GKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWR 242
            ||||||||||||||||||||.|||.||||||||||||||||||||||||||||||:|||||||||
Zfish   194 GKFVALENISCKIKSGCEGHPPWPEGICTKCQPSAITLNRQKYRHVDNIMFENHTIADRFLDFWR 258

Human   243 KTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRK 307
            |||||..||||||||||||||||||||||||||||||.|||||||:|||||:.|:||||||||||
Zfish   259 KTGNQRMGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIATQNSLELIEDPKADAVEEIAAKLGLRK 323

Human   308 VGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGSKFVTAVA 372
            ||||||||:|||||.|||||:||||:||||:|||||||.|||:..|||||||||||||||||.||
Zfish   324 VGWIFTDLLSEDTRIGTVRYTRNKDSYFLSAEECITAGHFQNQQANMCRLSPDGHFGSKFVTVVA 388

Human   373 TGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDVDKFGNEIT 437
            |||||||||||||||||||||||||||||||:||||||||||||:|||||||||||.|||||:||
Zfish   389 TGGPDNQVHFEGYQVSNQCMALVRDECLLPCRDAPELGYAKESSTEQYVPDVFYKDKDKFGNDIT 453

Human   438 QLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSV-FL 501
            .|||||||||||||||||||||||:||| |...|||||||.||||||||||||||||.|||. ||
Zfish   454 HLARPLPVEYLIIDITTTFPKDPVFTFS-STFRFPIENRDALGETQDFHSLATYLSQCTSSTSFL 517

Human   502 DTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKRSEQWATIEQLCS--------- 557
            |.:|||||||||||||||||||||.|||:||:|.|||||||||:||||||||||||
Zfish   518 DIVSDFHLLLFLVTNEVMPLQDSIGLLLDAVKTSNEELAQTWKKSEQWATIEQLCSTVGGQSSGS 582

Human   558 -EYPHPLPRHPVAGAGEQPTLH 578
             :|....|..|.:.:.....||
Zfish   583 LDYAMGGPPLPQSSSAVWSCLH 604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPLOC4	NP_001424915.1	None
nploc4	NP_956101.1	UN_NPL4	1..79	CDD:431926	60/78 (77%)
		zf-NPL4	123..261	CDD:461523	128/137 (93%)
		MPN_NPL4	230..529	CDD:163692	265/299 (89%)
		RanBP2-type Zn finger	600..619	CDD:275376	2/5 (40%)