Protein Alignment NPLOC4 and npl4

DIOPT Version :10

• Sequence 1: NP_001424915.1
• Gene: NPLOC4 / 55666
• HGNCID: 18261
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_595883.2
• Gene: npl4 / 2539821
• PomBaseID: SPBC1711.10C
• Length: 572
• Species: Schizosaccharomyces pombe
• Alignment Length: 577
• Identity: 200/577 - (34%)
• Similarity: 311/577 - (53%)
• Gaps: 42/577 - (7%)

Human     5 IIIRVQSPDGVKRITATKRETAATFLKKVAKEF---GFQNNGFSVYINRNKTGEITASSN-KSLN 65
            :|:|.:|..|:.|......:|.|....|:..:.   .:.....|:..|.:..|.|.::.| ::|.
pombe     1 MILRFRSKRGMARAEFQPTDTLAMLSAKILSDILKNDYSPENVSLCQNESDQGVIFSNLNDQTLQ 65

Human    66 LLKIKHGDLLFLFPSSLAGPSSEMETS-VPPGFKVFGAPN---------------VVEDEIDQYL 114
            ...:.||.:|:|   .|..|:|::.:| ..|...|.|||.               |::|.||..|
pombe    66 DAGLTHGQMLYL---RLGTPNSDIASSNNEPALTVTGAPKQVSTPDVSEKKPSMPVIQDPIDDSL 127

Human   115 SKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADK-- 177
            .|:||.|.||. ..||||||.|.|.:|.||||:||.|  ..|..:||:|||||:||:....:|
pombe   128 EKEDGLIRRSM-TSLCRHGPKGMCDYCSPLEPYDESY--RQENKIKHLSFHAYLRKINSNVNKYA 189

Human   178 --GKFV-ALENISCKIKSGC-EGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFL 238
              ..|: .||..|..:|..| .||.|||.|||||||||.:.||.|.:|.:|:|.|.:..:.|.||
pombe   190 SSQSFIPPLEEPSFTVKEKCPSGHPPWPAGICTKCQPSTVMLNLQPFRVIDHIEFASPGIVDSFL 254

Human   239 DFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKL 303
            :.||::|.|..||.||.:.::.::||||:..:.|||||||:...:.:.|.|.....:|:::|...
pombe   255 NKWRQSGFQRIGYTYGHFEQYNNVPLGIKGVIEAIYEPPQVSEADGVTLEEWADEALVEQVATAC 319

Human   304 GLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGSKFV 368
            |||::|.|||||..:.:..|.|...|:.|:|||||.|...:.:||.|..|.|:.|..|:||||||
pombe   320 GLRRIGIIFTDLTDDGSNSGKVLCKRHSDSYFLSSLEVYNSANFQTKFKNPCKWSRSGYFGSKFV 384

Human   369 TAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDVDKFG 433
            |:|.:|..:.::....|||||...||.:.:.:.|..| |:....|:....:|||||.|:..||:|
pombe   385 TSVISGNLNGEIEVMSYQVSNIGTALYQADLIQPSVD-PDRMLVKKEDQTRYVPDVLYRYTDKYG 448

Human   434 NEITQLARP-LPVEYLIIDITTTFPK--DPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQN 495
            .::::.|:| .||.:|::.:|..||:  ||:::.:.:.....:|:.|   ||.....||.....|
pombe   449 KQVSENAKPAFPVSFLLVTLTDGFPEKPDPLFSNNDTSIITTLESTD---ETGRLRQLAKLFDHN 510

Human   496 TSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKRSEQWATI 552
              ::...::|:|.:||.:....::. :|.::.|........||..:.....|.:.|:
pombe   511 --AIANGSLSNFSVLLAIAKLSILG-KDDLAALASYATAPTEENEKNLNSRESYQTL 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPLOC4	NP_001424915.1	None
npl4	NP_595883.2	NPL4	1..571	CDD:227431	200/577 (35%)