Protein Alignment NPLOC4 and npl-4.1

DIOPT Version :10

• Sequence 1: NP_001424915.1
• Gene: NPLOC4 / 55666
• HGNCID: 18261
• Length: 617
• Species: Homo sapiens
• Sequence 2: NP_495096.1
• Gene: npl-4.1 / 173952
• WormBaseID: WBGene00019120
• Length: 529
• Species: Caenorhabditis elegans
• Alignment Length: 491
• Identity: 216/491 - (43%)
• Similarity: 311/491 - (63%)
• Gaps: 28/491 - (5%)

Human   108 DEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLT 172
            :::|.:||.|||:|.|.:.|. |||....||.:|:|::||||:||.  |..:|||||||::|||.
 Worm    12 NDVDVFLSTQDGQIQRPKGPN-CRHPVRQKCTNCLPVDPFDEEYLK--EKDIKHMSFHAHVRKLL 73

Human   173 GGADKGKFV--ALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVAD 235
            |...||..:  .|||..|.:|..|:.|.|:|.||||||:|..:||||||:||||||..||..:.:
 Worm    74 GSQGKGTTLKKPLENFRCSLKPNCDAHKPFPKGICTKCKPQVVTLNRQKFRHVDNIQIENQELVN 138

Human   236 RFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIA 300
            :|||:||.:|:|..|:|.|:|..|.::||||:|.|||||||||...::.:|.|||...:.:|.:.
 Worm   139 QFLDYWRLSGHQRVGFLIGQYQPHLEVPLGIKATVAAIYEPPQHCREDGIEFLEDKNQKTIDNLL 203

Human   301 AKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGS 365
            ..|||::|||||||..:.::.:|||.|:|:||::|||:||||||...||:|||:...|.|.|:||
 Worm   204 EMLGLQRVGWIFTDCWTANSAEGTVHYTRHKDSFFLSAEECITAAMLQNQHPNITEYSMDRHYGS 268

Human   366 KFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKES--SSEQYVPDVFYKD 428
            ||||.||:|.....|:|.||||||||.|:|..:.|.|....|||.|.:|:  |.|.|:.||.:..
 Worm   269 KFVTVVASGDESMHVNFHGYQVSNQCAAMVEADILCPTLYTPELAYVRETPLSEEHYITDVQFSM 333

Human   429 VDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQN------PFPIENRDVLGETQDFHS 487
            .:::|.|:.:..||||||||::|:....||:|.|||.:..:      .|.:|||..:|:.|...:
 Worm   334 KNEYGAEVMKNGRPLPVEYLLVDVPAGMPKEPHYTFHVGTSNKSKSAKFNVENRQAIGQLQGGAN 398

Human   488 LATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDS-ISLLLEAVRTRNEELAQTW-KRSEQWA 550
            |..|.|:.:.:.||:..::||.||:||||:.:.:.|. :..|.:||:.::...|..| :..|.|.
 Worm   399 LIQYSSEFSKNQFLEQATNFHFLLYLVTNDQVQISDEWMKRLCDAVKAQDRGTAMEWAQECEDWH 463

Human   551 TIEQLCSEYPHPLPRHPVAGAGEQPTLHSSPLPVVP 586
            .:..|.         |...|:|..    .|.:||:|
 Worm   464 QLMALA---------HANGGSGND----VSDIPVIP 486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPLOC4	NP_001424915.1	None
npl-4.1	NP_495096.1	zf-NPL4	13..148	CDD:461523	71/137 (52%)
		NPL4	151..470	CDD:461524	136/327 (42%)
		ZnF_RBZ	504..526	CDD:197784
		RanBP2-type Zn finger	504..523	CDD:275376