DRSC/TRiP Functional Genomics Resources

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Protein Alignment NPLOC4 and nploc4

DIOPT Version :10

Sequence 1:NP_001424915.1 Gene:NPLOC4 / 55666 HGNCID:18261 Length:617 Species:Homo sapiens
Sequence 2:NP_001135712.1 Gene:nploc4 / 100216289 XenbaseID:XB-GENE-958208 Length:610 Species:Xenopus tropicalis


Alignment Length:579 Identity:502/579 - (86%)
Similarity:533/579 - (92%) Gaps:11/579 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     1 MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLN 65
            |:|||.||:|||||||||.|:|||:||||||||||||||:|||||||:|||:||||:|:.||||:
 Frog     1 MSESITIRIQSPDGVKRINASKRESAATFLKKVAKEFGFRNNGFSVYVNRNRTGEISATQNKSLH 65

Human    66 LLKIKHGDLLFLFPSS---LAGPSSE-METSVPPGFKVFG--APNVVEDEIDQYLSKQDGKIYRS 124
            .|||||||:|||||||   ||||||: |:||.    .|.|  :|.|||||||||||||||||||:
 Frog    66 FLKIKHGDMLFLFPSSSAGLAGPSSDVMDTSA----TVSGSRSPQVVEDEIDQYLSKQDGKIYRN 126

Human   125 RDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCK 189
            |||||||||||||||||||||||||||||||:||||||||||.||||||||||||||||||||||
 Frog   127 RDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLDPPVKHMSFHANIRKLTGGADKGKFVALENISCK 191

Human   190 IKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYG 254
            ||||||||.|||.||||||||||||||||||||||||||||||:||||||||||||||..|||||
 Frog   192 IKSGCEGHPPWPEGICTKCQPSAITLNRQKYRHVDNIMFENHTIADRFLDFWRKTGNQRIGYLYG 256

Human   255 RYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSED 319
            |||||||||||:|||||||||||||||||||:||:||||:|||||||||||||||||||||||||
 Frog   257 RYTEHKDIPLGLRAEVAAIYEPPQIGTQNSLQLLDDPKAKVVDEIAAKLGLRKVGWIFTDLVSED 321

Human   320 TRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGSKFVTAVATGGPDNQVHFEG 384
            ||||||||||||||||||:|||||:|.|||||||:|||||||||||||||.||||||||||||||
 Frog   322 TRKGTVRYSRNKDTYFLSAEECITSGFFQNKHPNLCRLSPDGHFGSKFVTVVATGGPDNQVHFEG 386

Human   385 YQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDVDKFGNEITQLARPLPVEYLI 449
            |||||||||||||||||||:||||||||||||||||||||||||:||||||||||||||||||||
 Frog   387 YQVSNQCMALVRDECLLPCRDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLI 451

Human   450 IDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLV 514
            ||||.|||||||||||.|.|.|.|||||.|||||||||||||||||.|||||:.|||||||||||
 Frog   452 IDITATFPKDPVYTFSTSSNLFSIENRDALGETQDFHSLATYLSQNLSSVFLEIISDFHLLLFLV 516

Human   515 TNEVMPLQDSISLLLEAVRTRNEELAQTWKRSEQWATIEQLCSEYPH-PLPRHPVAGAG 572
            ||:|||||:||.|||:||||||||||||||:||||||||||||...| |...|.....|
 Frog   517 TNDVMPLQESIGLLLDAVRTRNEELAQTWKKSEQWATIEQLCSTVGHQPSELHDYGAIG 575

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NPLOC4NP_001424915.1 None
nploc4NP_001135712.1 UN_NPL4 1..80 CDD:431926 63/78 (81%)
zf-NPL4 107..247 CDD:461523 133/139 (96%)
NPL4 250..557 CDD:461524 279/306 (91%)
RanBP2-type Zn finger 586..605 CDD:275376
Blue background indicates that the domain is not in the aligned region.

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