Protein Alignment PRKACA and for

DIOPT Version :10

• Sequence 1: NP_001291278.1
• Gene: PRKACA / 5566
• HGNCID: 9380
• Length: 427
• Species: Homo sapiens
• Sequence 2: NP_477487.1
• Gene: for / 44817
• FlyBaseID: FBgn0000721
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 315
• Identity: 129/315 - (40%)
• Similarity: 200/315 - (63%)
• Gaps: 14/315 - (4%)

Human    98 KAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVK-HKETGNHYAMKILDKQKVVKLKQ 161
            |..|:|         ...:|.....|.|||.|.||||.||: :.::...:|:|.:.|.::|:.:|
  Fly   764 KINEEF---------RDINLTDLRVIATLGVGGFGRVELVQTNGDSSRSFALKQMKKSQIVETRQ 819

Human   162 IEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQ 226
            .:|.::||.|:...|..|:|||..:|||...|||:||...|||:::.||..|.|.:...|||.|.
  Fly   820 QQHIMSEKEIMGEANCQFIVKLFKTFKDKKYLYMLMESCLGGELWTILRDKGNFDDSTTRFYTAC 884

Human   227 IVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVK-GR-TWTLCGTPEYLAPEIILS 289
            :|..|:||||.::|||||||||||::::||:::.||||||::: || |||.||||||:|||:||:
  Fly   885 VVEAFDYLHSRNIIYRDLKPENLLLNERGYVKLVDFGFAKKLQTGRKTWTFCGTPEYVAPEVILN 949

Human   290 KGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQV 352
            :|::.:.|:|:||||::|:..|.|||....|::.|..|:.|  .:.||.:.:.:..:|::.|.:.
  Fly   950 RGHDISADYWSLGVLMFELLTGTPPFTGSDPMRTYNIILKGIDAIEFPRNITRNASNLIKKLCRD 1014

Human   353 DLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 407
            :..:|.|..:.|:::|:.||||....|..:....:|.|..|..|...||:|||||
  Fly  1015 NPAERLGYQRGGISEIQKHKWFDGFYWWGLQNCTLEPPIKPAVKSVVDTTNFDDY 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	123/293 (42%)
for	NP_477487.1	DD_cGKI-alpha	385..432	CDD:213374
		CAP_ED	520..629	CDD:237999
		CAP_ED	638..754	CDD:237999
		STKc_cGK	783..1043	CDD:270724	112/259 (43%)