DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PRKACA and Pkg21D

DIOPT Version :9

Sequence 1:	NP_001291278.1	Gene:	PRKACA / 5566	HGNCID:	9380	Length:	427	Species:	Homo sapiens
Sequence 2:	NP_477213.1	Gene:	Pkg21D / 33253	FlyBaseID:	FBgn0000442	Length:	768	Species:	Drosophila melanogaster

Alignment Length:	297	Identity:	127/297 - (42%)
Similarity:	188/297 - (63%)	Gaps:	6/297 - (2%)

- Green bases have known domain annotations that are detailed below.

Human   117 LDQFERIKTLGTGSFGRVMLVK--HKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF 179
            |...|.:.|||.|.||||.|||  |::..:.:|:|.|.|:.:|..||.||..:|:.|:.:...||
  Fly   454 LTDLEVVSTLGIGGFGRVELVKAHHQDRVDIFALKCLKKRHIVDTKQEEHIFSERHIMLSSRSPF 518

Human   180 LVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDL 244
            :.:|..:|:|...:||::|...|||:::.||..|.|.:..|:|....::..|||||:..:|||||
  Fly   519 ICRLYRTFRDEKYVYMLLEACMGGEIWTMLRDRGSFEDNAAQFIIGCVLQAFEYLHARGIIYRDL 583

Human   245 KPENLLIDQQGYIQVTDFGFAKRV--KGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYE 307
            |||||::|::||:::.||||||::  ..:|||.||||||:||||||:||:::|||:||||:||:|
  Fly   584 KPENLMLDERGYVKIVDFGFAKQIGTSSKTWTFCGTPEYVAPEIILNKGHDRAVDYWALGILIHE 648

Human   308 MAAGYPPFFADQPIQIYEKIVSG--KVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKN 370
            :..|.|||.|..|:|.|..|:.|  .:.||.|.|.....|::.|.:...::|.|....|:.|||.
  Fly   649 LLNGTPPFSAPDPMQTYNLILKGIDMIAFPKHISRWAVQLIKRLCRDVPSERLGYQTGGIQDIKK 713

Human   371 HKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDY 407
            ||||...||..:..:.:..||:.....|.|...||.:
  Fly   714 HKWFLGFDWDGLASQLLIPPFVRPIAHPTDVRYFDRF 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PRKACA	NP_001291278.1	STKc_PKA	118..407	CDD:271111	126/294 (43%)
PRKACA	NP_001291278.1	S_TKc	120..374	CDD:214567	116/259 (45%)
Pkg21D	NP_477213.1	Crp	183..386	CDD:223736
		CAP_ED	185..285	CDD:237999
		CAP_ED	304..419	CDD:237999
		Pkinase	457..717	CDD:278497	116/259 (45%)
		STKc_cGK	463..724	CDD:270724	118/260 (45%)
		S_TK_X	719..>760	CDD:214529	8/32 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142887
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840