Protein Alignment INTS8 and ints8

DIOPT Version :10

• Sequence 1: NP_060334.2
• Gene: INTS8 / 55656
• HGNCID: 26048
• Length: 995
• Species: Homo sapiens
• Sequence 2: NP_001018592.2
• Gene: ints8 / 553794
• ZFINID: ZDB-GENE-050522-556
• Length: 996
• Species: Danio rerio
• Alignment Length: 997
• Identity: 696/997 - (69%)
• Similarity: 821/997 - (82%)
• Gaps: 3/997 - (0%)

Human     1 MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASKPSVNE 65
            ||||||||||.:.|||||||||.||||||..||||:||..|.|||:|||||.|||||||||||||
Zfish     1 MSAEAADREAVSGSRPCTPPQTSWFEFLLNPSLLEQHLHSPHPDPSPVQLIFQFLEQASKPSVNE 65

Human    66 QNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDM 130
            |||||||.||:|||.|||:||||||||:|||::|||.|::||||||||||||:|.||||.||||:
Zfish    66 QNQVQPPVDNRRNRTLKLMALKVAAHLRWDLNMLEKGLTIPVLNMLLNELLCVSHVPPGVKHVDL 130

Human   131 DLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQA 195
            ||::|||||||||:.||||||||||.||||.||.||||.||::||.:|||||.|||||.||:|||
Zfish   131 DLSSLPPTTAMAVVFYNRWAIRTIVLSSFPEKQTKPGPHQLNMMNMLQQEKEHTENILSVLREQA 195

Human   196 ADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAGLKVKTEEMQCQVCYDLGAAY 260
            .|||:|||.||.:.||.|:||:|||||||.:|...|||||.|||||::..:.:.|||.||||..|
Zfish   196 TDSIVVLEGALSIKKDFYIHTLRTLDLLAADPSTTNGETEYSTAGLRISFDHLHCQVHYDLGGIY 260

Human   261 FQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDSTSQQLTP 325
            ||||.::::|||.|||.|.:.:||:.::...:..|.:||:|||||..||..|..:||....|.||
Zfish   261 FQQGCSDTSVYEKAREHFRKARELLTKLDFSASFCCLDEQRLAGYWSACRTLTGTSDLNESQHTP 325

Human   326 YSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQSVLRELFKKAQQGNEALDEICFKVCACNTV 390
            |.|:...:|:.||..:|:.||.||:|||||..||.|:..||..|.|||:.||:|:|.|:|.||.|
Zfish   326 YGQISCFMRNHNYGALIEEFICDNVTLSLPNSFRHSIQLELMHKLQQGDSALEEVCNKLCVCNAV 390

Human   391 RDILEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQY 455
            ||.|||..:||.|:||.|:|:|..|.||||||:||:..|...|..|..||.|:|.||..|.|:..
Zfish   391 RDALEGGILSVSFHQLLLKPSKNIISFLLEVCTRSLEKENLPELSKSKMALFIKTVCDQLGDVSL 455

Human   456 VFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSV 520
            .||:|||:||..||::||:|:|::||||.|..:||..||:.|||||||||||||.|||.|||||:
Zfish   456 AFMVSSHKLFKELLQEEEKKILMEQMRKSSDVINLSSKPLPSFYDIPASASVNISQLEQQLILSL 520

Human   521 DPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKD 585
            |...||||||||||| :||.||.|:.|||||..|..|||.|||.|||||||||:||||||..:.|
Zfish   521 DARHIRQILIELHGM-AERPFWMVNTKWEVPVDYVNVILAIKDKLTRDLVYILLAKGLHCINITD 584

Human   586 FSHAKQLFAACLELVTEFSPKLRQVMLNEMLLLDIHTHEAGTGQAG-ERPPSDLISRVRGYLEMR 649
            |.||.|||.||||||||||||||||||||:||:::..||.||.:.. .|||.||:||||||||||
Zfish   585 FVHACQLFTACLELVTEFSPKLRQVMLNELLLMEVRAHEEGTAKGRIVRPPPDLVSRVRGYLEMR 649

Human   650 LPDIPLRQVIAEECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTA 714
            :.|:||||.:.||||.||||||||||||||||..|:.:|||:|||.|:|:|||||||||||||||
Zfish   650 IHDLPLRQTVGEECVVFMLNWRENEYLTLQVPQSLVNNNPYIKLGHLIASTCKELPGPKESRRTA 714

Human   715 KDLWEVVVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVK 779
            |:||||||||||.||||||.:|.||||:|||||:|||:.||:.::|:||:|||||||.::||||:
Zfish   715 KELWEVVVQICSFSSQHKRTSDSRVSLLKQRESSLGILPRSKFITFVKKIREPLVLTTLISLFVR 779

Human   780 LHN-VREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQADIY 843
            ||: ||:||||::|||||||||||:.||||||.:||.||:||||.|.||:||||.|||..|||||
Zfish   780 LHSIVRDDIVNEVTAEHISIWPSSLTNLQSVDVDAVVITLKELVNYALSLNPNNQSWLCTQADIY 844

Human   844 FATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREID 908
            |.|||||.|:|||||||.||||||.|.||||||||||:|||||||||||||||||:|||||||:|
Zfish   845 FVTNQYSTAMHYYLQAGTVCSDFFTKPVPPDVYTDQVLKRMIKCCSLLNCHTQVAVLCQFLREVD 909

Human   909 YKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEE 973
            |.||||:||||||||:|||:|||||||||||||||:||||||:||||:||||||:.|||:|||||
Zfish   910 YMTAFKALQEQNSHDSMDSFYDYIWDVTILEYLTYIHHKRGESDKRQVAIKAIGRNELNSSNPEE 974

Human   974 VLQLAAQRRKKKFLQAMAKLYF 995
            |:|||||:|||:||||||||||
Zfish   975 VMQLAAQKRKKRFLQAMAKLYF 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS8	NP_060334.2	WFEF motif. /evidence=ECO:0000269|PubMed:32966759	24..29		4/4 (100%)
		TPR 1	250..288		21/37 (57%)
		TPR 2	320..356		17/35 (49%)
		TPR 3	570..603		24/32 (75%)
		TPR 4	833..866		25/32 (78%)
ints8	NP_001018592.2	TPR_2	252..284	CDD:429619	17/31 (55%)