Protein Alignment INTS8 and IntS8

DIOPT Version :10

• Sequence 1: NP_060334.2
• Gene: INTS8 / 55656
• HGNCID: 26048
• Length: 995
• Species: Homo sapiens
• Sequence 2: NP_611162.2
• Gene: IntS8 / 36886
• FlyBaseID: FBgn0289323
• Length: 1007
• Species: Drosophila melanogaster
• Alignment Length: 1076
• Identity: 293/1076 - (27%)
• Similarity: 477/1076 - (44%)
• Gaps: 178/1076 - (16%)

Human    16 PCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFL--------EQASKPSVNEQNQVQPP 72
            |.......||||||:...:.:||::|.|:|:.::|||||:        |....|..:.||..|.|
  Fly    11 PLAAETVLWFEFLLDPHKITQHLQRPHPEPSAMELIVQFISMTPNTAQESVGTPGSDLQNLNQTP 75

Human    73 PD---------------------------------------NKRNRILKLLALKVAAHLKWDLDI 98
            .:                                       |::...||:|.||||..||||||.
  Fly    76 SNSGPIPGVVGGAPAPTTPTASGGVGMPHSPQRPAEKGLQLNRKQLALKILELKVATWLKWDLDA 140

Human    99 LEKSLSVPVLNMLLNELLCIS-----KVP-PGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQS 157
            |||:|.|.:...||.:|..||     .:| |......:..|........|:.:|:|..:|..:..
  Fly   141 LEKNLPVIMQLALLRDLCTISYGCSLSIPLPNDFDARISAAGNERAARFALTIYHRMLLRMQLIK 205

Human   158 SFPVKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQAADSILVLEAALKLNKDLYV-HTMRTLD 221
            ...:|..:|.......::|:||          .|......||..|:......|..|: |....:.
  Fly   206 EQALKAPRPQNTMYQTVDQLQQ----------FLDTPTQPSIEYLQQLCASTKPFYIFHYDSFVP 260

Human   222 LLAMEPGMVNGETESSTAGLKVKTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIA 286
            |...:.|  ||:......  .:..:|::.|:.|:|...|..     :..|..|||........:.
  Fly   261 LRCDDIG--NGQNYDVMH--LITPQELRAQLHYELAQYYLY-----TKQYVLAREAAAACNTNLQ 316

Human   287 EI--GSLSLHCTIDEKRLAGYCQACDVLVPSSDSTSQQ--LTPYSQVHICLRSGNYQEVIQIFIE 347
            .|  .:...:|.|....|.|..|||.:      |..:|  |..:.|..:    .||.:::.|...
  Fly   317 AIPPQTTLYYCHIRPSELEGLLQACGI------SAEEQSLLEKFQQSLL----NNYTDIVSILRM 371

Human   348 DNLTLSLPVQFRQSVLRELFKKAQQG--NEALDEICFKVCACNTVRDILEGRTI--SVQFNQLF- 407
            ||....:|...|:.|..::......|  .|.: ::..:|.|.|.||:|.|..:|  ||::.:.:
  Fly   372 DNRRREIPFISRRQVELDIEGSISTGILKETV-QLQLQVAALNVVRNIFEWGSIFGSVEYFEKYR 435

Human   408 ----LRPNKEKIDFLLEVCSRSVNLEKASESLKGNMAAFLKNVCL---GLEDLQYVFMISSHELF 465
                |.|..|.:..:|..|:     .|...:||    .||.: ||   |.:..|.:..:....||
  Fly   436 ELDCLPPLVEALQEMLPHCT-----FKEQAALK----HFLID-CLLHQGGQSRQLLQTVRGFGLF 490

Human   466 ITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASAS----------VNIGQLEHQLILSV 520
                ..:|.:.:.:||.:.:|.|     |..|.    ||.|          |::|.||.|||...
  Fly   491 ----SSDELQDIDEQMLQATPPV-----PTNSL----ASLSDWMCHSKMSRVDVGALERQLISCT 542

Human   521 DPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKD 585
            :...:|.:|::|......:..|.::..|:||.....:|:.:..:..:|..|:|:.|....:|..:
  Fly   543 NANTVRILLVKLCATAPGKPLWAINPSWDVPQPLKTLIMAMPVSFLQDFSYVLLGKARELATRGN 607

Human   586 FSHAKQLFAACLELVTEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGE------RPPSDLIS---- 640
            :..|..:.:     |.:...:.:::..|..|:..:.|.|....|..:      :.|.||.|
  Fly   608 YIDAVSMLS-----VLKSENQRQEMAANVQLMCKLITWEILHIQITQCLEEWHQKPLDLQSLGGR 667

Human   641 --RVRGYLEMRLPDIPLRQVIAEECVAFMLNWRENEYLTLQVPAFLL--QSNPYVKLGQLLAATC 701
              :..|.|:.....:| |..|.|.|...:||      ||...|...|  ::.| ::|....|||.
  Fly   668 CKQCLGALQAGDSIVP-RPDILESCAIMLLN------LTEFPPLLYLDKRAGP-LELPLAFAATF 724

Human   702 KELPGPKESRRTAKDLWEVVVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLRE 766
            .|:...|..::..:|.||:::.:  ..:..|||:.|          ..||   |.|.:|::::|.
  Fly   725 IEMEKMKGPKKVCRDAWELMLSM--FLNVPKRGSSG----------VGGI---SSLQAFLQRIRH 774

Human   767 PLVLTIILSLFVKLHNVREDIVN-DITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINP 830
            ..|..:.:|:..|:||:.:|..| |::.|::.:||:||.|..|....:|..|::.|:...||..|
  Fly   775 QSVFGLAISMIGKVHNILKDDPNHDLSCEYMQLWPTSINNPVSYSLRSVCETLQWLLSEALSYYP 839

Human   831 NNHSWLIIQADIYFATNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHT 895
            ...|||.::.|:..|.....:|:..|:.|....:|:....:..:|..|.||::||:|.:.|.||.
  Fly   840 QTISWLKMKGDLDLAIGNNESAMRCYVNALVTGTDYCTMPLQRNVADDYVIRKMIRCAANLGCHM 904

Human   896 QVAILCQFLREIDYKTAFKSLQEQNSH--DAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAI 958
            |..:|||||.||||...||:|.|::|:  ||||:||..|||.|:||::..||.||||..::..||
  Fly   905 QATVLCQFLDEIDYGIVFKNLSEKSSNFTDAMDAYYSCIWDTTLLEFIVNLHAKRGEHSRKLEAI 969

Human   959 KAIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLY 994
            ..:|..||||:|.||:.:.:|..||.:||:|:||.|
  Fly   970 SMMGTLELNANNNEEIKRESAMVRKSRFLRALAKQY 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS8	NP_060334.2	WFEF motif. /evidence=ECO:0000269|PubMed:32966759	24..29		4/4 (100%)
		TPR 1	250..288		8/37 (22%)
		TPR 2	320..356		8/37 (22%)
		TPR 3	570..603		6/32 (19%)
		TPR 4	833..866		8/32 (25%)
IntS8	NP_611162.2	None