Protein Alignment INTS8 and ints-8

DIOPT Version :10

• Sequence 1: NP_060334.2
• Gene: INTS8 / 55656
• HGNCID: 26048
• Length: 995
• Species: Homo sapiens
• Sequence 2: NP_001252168.1
• Gene: ints-8 / 173216
• WormBaseID: WBGene00013021
• Length: 977
• Species: Caenorhabditis elegans
• Alignment Length: 1141
• Identity: 220/1141 - (19%)
• Similarity: 395/1141 - (34%)
• Gaps: 348/1141 - (30%)

Human    24 WFEFLLE-----ESLLEKHLRKPCPDPAPVQLIVQFLEQA---------SKPSVNEQNQVQPPPD 74
            |||..::     :|||:...||..|     :|.:||.::.         .|.:|.|....:
 Worm    12 WFELFVDPTCISKSLLDPEKRKQLP-----RLCMQFTDKGFLAEREKDKGKLAVEELMLFE---- 67

Human    75 NKRNRILKLLALKVAAHLKWDLDIL------------------------EKSLSVPVLNMLLNE- 114
             ::...::|.|:...|.|.:|::.:                        ||:|.....|.|...
 Worm    68 -RKAASMRLCAMATFAALDYDIEFIIDNIPRNEIQTLRVLADNFYRIYNEKNLDATFGNWLFYRF 131

Human   115 LLCISK----VPPGTKHVDMDLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMN 175
            :|.|.:    .||..:      ||:|.|.:...|:                    |..|.|
 Worm   132 VLSIDRRNRLAPPAPR------ATIPTTLSNGQLM--------------------PTDPAL---- 166

Human   176 QMQQEK------ELTENILKV------LKEQAADSILV-LEAALKLNKDLYVHTMRTLDLLAMEP 227
             ::.||      ||.|::||.      |.|...|.:.. ::..||...:|....|....|
 Worm   167 -LKHEKTQRTIMELKEHVLKARAFITELAEVPRDVVAPGIQCFLKPFVELAPKAMTAAFL----- 225

Human   228 GMVNGETESSTAGLKV-----KTEEMQCQVCYDLGAAYFQQGSTNSAVYENAREKFFRTKELIAE 287
            |..|...|:.:|..:|     ...::..:...:|....|..|....|            |:::..
 Worm   226 GDRNVLIENPSADFEVDKVLLSAGDVSNKCLSELVTFLFTSGELQEA------------KKILTR 278

Human   288 IGSLSL-H--CTIDEKRLAGYCQACDVL-VPSSDST--SQQLTPY--------------SQVHIC 332
            :...:: |  ..|||.....|||..:.. .|.|.||  |..|.||              |:|
 Worm   279 VVKPTVTHPLVAIDETIFKSYCQILNAQGTPYSSSTASSSLLKPYVFDLNSLNDEKMRRSEV--- 340

Human   333 LRSGNYQEVI----QIFIEDNLTLSL----PVQFRQSVLR--------ELFKKAQQG-------- 373
            ||....||..    .:::.:|..||:    |...|:|:..        ::.|:...|
 Worm   341 LRHRGVQETTGQLQNVYLAENAALSVIDEHPECIRESIRNRAEIERFVKVLKRKTDGIRDKRKLA 405

Human   374 --NEALDEICFKVCACNTVRDILEG--------RTISVQFNQLFLRPNKEKIDFLLEVCSRSVNL 428
              ...|..:|..:   :.:|||||.        ||.:|....|.|.|..     ...|....|:.
 Worm   406 AIRAHLQYLCASI---SDLRDILETNGMDVSQLRTFAVPSEHLKLEPPP-----AFHVLEELVSG 462

Human   429 EKASESLKGNMAAFLKNVCLGLEDLQYVFMISSHELFITLLKDEERKL--------------LVD 479
            |:..::.:|.....:..: ..|......:.|...|..|..|::...||              |::
 Worm   463 ERKIDAAQGPSTHEISRI-FPLPRAADPYWIIMTEYDIPTLQNALTKLGPFWFPTKMQVPEHLME 526

Human   480 QMRKRS--PRVNLCIKPVTSFYDIPASASVNIGQLEHQLIL-SVDPW-------RIRQIL-IELH 533
            ::.|.|  |..||                       |:|:| .:|..       :.:.:| :.||
 Worm   527 KLEKHSNLPTYNL-----------------------HRLLLCKIDQLSKMHHFEKFKDVLSLALH 568

Human   534 GMTSERQFWTVSNKWE---VPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKDFSHAKQLFAA 595
            .:....:.|.::..:|   ||::               :|....|...| |..:||:..:.:|.:
 Worm   569 SLKLVHESWVMTAAFEMIQVPAI---------------IVNQQFAWERH-SLERDFAQTQLIFNS 617

Human   596 CLELVTEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEM-RLPDIPLRQVI 659
            ...:..::|..    |:||.|.|.|:..:|.:           :....|.|.| |...:|:.::.
 Worm   618 DHFVPNDYSAG----MINECLGLMINIGDAQS-----------VLEKGGQLSMERFKSVPIARMF 667

Human   660 AEECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAKDLWEVVVQI 724
            .    |:::|:.:                                  |...::.|...|..|.|.
 Worm   668 G----AYLVNYSD----------------------------------PATRKKCADGFWRTVTQR 694

Human   725 CSVSSQ----HKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKLHNVRE 785
            . :.:|    .:|||:...:|:..|:..      ::|......:|:..|:..:|:..|.|||  :
 Worm   695 L-LEAQPPRGFRRGNEVEQALLVTRKEL------ADLFHLFSLIRDQRVVDFLLAYAVCLHN--K 750

Human   786 DIVND------ITAEHISIWPSSIPNLQSVDF---EAVAITVKELVRYTLSINPNNHSWLIIQAD 841
            .::..      |.|:.:.::... ||...:|.   :.|...::.:|....|::|.:...:...||
 Worm   751 VVIGQRKSNLKIHAKLLDLYTPD-PNAPKIDISNPDDVRQLLQLMVEKAYSLSPTDPDTIRTYAD 814

Human   842 IYFATNQYSAALHYYLQAGAVCSDFFN------KAVPPDVYT---DQVIKRMIKCCSLLNCHTQV 897
            ..:....:..|...|:       ::|.      :..|.|.:|   |.|::|:..|.:.....|..
 Worm   815 FLYVERDFQGAAQKYM-------EYFTAHSPTLRLSPFDAFTVFDDTVVQRLRYCTANAGYLTMS 872

Human   898 AILCQFL---REIDYKTAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIK 959
            .:.||:|   :...|:.|...|:...:.|...:..||:.||..:|.|:..:|....|........
 Worm   873 LLTCQWLKVGKTNAYQKAMAVLEHNETRDVGANCADYVTDVVAIELLSQHYHSMMMTKSLDTLYT 937

Human   960 AIGQTELNASNPEEVLQLAAQRRKKKFLQAMAKLYF 995
            .......|.:.|:.:......||..|||.|::.:||
 Worm   938 GANSLSANKNVPQVLATQEINRRTTKFLTALSSIYF 973

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS8	NP_060334.2	WFEF motif. /evidence=ECO:0000269|PubMed:32966759	24..29		3/4 (75%)
		TPR 1	250..288		5/37 (14%)
		TPR 2	320..356		13/57 (23%)
		TPR 3	570..603		7/32 (22%)
		TPR 4	833..866		4/32 (13%)
ints-8	NP_001252168.1	None