Protein Alignment INTS8 and ints8

DIOPT Version :10

• Sequence 1: NP_060334.2
• Gene: INTS8 / 55656
• HGNCID: 26048
• Length: 995
• Species: Homo sapiens
• Sequence 2: NP_001090873.1
• Gene: ints8 / 100038299
• XenbaseID: XB-GENE-980129
• Length: 991
• Species: Xenopus tropicalis
• Alignment Length: 995
• Identity: 798/995 - (80%)
• Similarity: 903/995 - (90%)
• Gaps: 4/995 - (0%)

Human     1 MSAEAADREAATSSRPCTPPQTCWFEFLLEESLLEKHLRKPCPDPAPVQLIVQFLEQASKPSVNE 65
            ||||||||||||||||||||||.||||||::|||||||:|...||.||||||||||||||||:||
 Frog     1 MSAEAADREAATSSRPCTPPQTSWFEFLLDDSLLEKHLQKSDSDPPPVQLIVQFLEQASKPSLNE 65

Human    66 QNQVQPPPDNKRNRILKLLALKVAAHLKWDLDILEKSLSVPVLNMLLNELLCISKVPPGTKHVDM 130
            |||||||.||||||.||||||||||:|||:||:|||||||||||||||||||:|||||||||||:
 Frog    66 QNQVQPPTDNKRNRTLKLLALKVAAYLKWNLDVLEKSLSVPVLNMLLNELLCVSKVPPGTKHVDL 130

Human   131 DLATLPPTTAMAVLLYNRWAIRTIVQSSFPVKQAKPGPPQLSVMNQMQQEKELTENILKVLKEQA 195
            ||:||||||.|||.|||||||||||||.||||..|.||.|.:||:|:||||||||||||||||||
 Frog   131 DLSTLPPTTVMAVTLYNRWAIRTIVQSGFPVKPVKQGPLQPNVMSQIQQEKELTENILKVLKEQA 195

Human   196 ADSILVLEAALKLNKDLYVHTMRTLDLLAMEPGMVNGETESSTAGLKVKTEEMQCQVCYDLGAAY 260
            .|||.|||.||:|.:|.||||||||||||:||||||||||:||||||:..||||||.|||||..|
 Frog   196 EDSITVLERALQLKRDFYVHTMRTLDLLAVEPGMVNGETENSTAGLKISFEEMQCQGCYDLGTVY 260

Human   261 FQQGSTNSAVYENAREKFFRTKELIAEIGSLSLHCTIDEKRLAGYCQACDVLVPSSDSTSQQLTP 325
            ||||.|||:.||.||:.|||||:|:::||:.|.||:||||||||||:||.||.||:..| :..||
 Frog   261 FQQGPTNSSCYEKARDHFFRTKQLVSKIGAASDHCSIDEKRLAGYCEACGVLAPSNVVT-EPATP 324

Human   326 YSQVHICLRSGNYQEVIQIFIEDNLTLSLPVQFRQSVLRELFKKAQQGNEALDEICFKVCACNTV 390
            |||:|..:::.:||.:::||:||||..|||.|||||||||||:||||||.||.|:||||||||||
 Frog   325 YSQIHSFMKTSSYQGILKIFLEDNLNNSLPDQFRQSVLRELFQKAQQGNGALAEVCFKVCACNTV 389

Human   391 RDILEGRTISVQFNQLFLRPNKEKIDFLLEVCSRSVNLEKASESLKGNMAAFLKNVCLGLEDLQY 455
            .||:.||.|:|||:|||:||:||||||||||||||:..|:.||:.|..:|.||||:||.:||||.
 Frog   390 CDIVHGRPITVQFHQLFMRPSKEKIDFLLEVCSRSLMSEQTSEASKRKIATFLKNLCLEIEDLQL 454

Human   456 VFMISSHELFITLLKDEERKLLVDQMRKRSPRVNLCIKPVTSFYDIPASASVNIGQLEHQLILSV 520
            ||||||||||:.:|.|||.|::|:.:||::.||:||.||||||||:|||||||||||||||||:|
 Frog   455 VFMISSHELFMKMLTDEESKMVVEHIRKKTSRVSLCTKPVTSFYDLPASASVNIGQLEHQLILTV 519

Human   521 DPWRIRQILIELHGMTSERQFWTVSNKWEVPSVYSGVILGIKDNLTRDLVYILMAKGLHCSTVKD 585
            ||||||||||||:|:||:.|:||||||||||::|:|.||||||||||||||:|:|||||||.:||
 Frog   520 DPWRIRQILIELNGLTSDSQYWTVSNKWEVPTIYTGSILGIKDNLTRDLVYVLLAKGLHCSAIKD 584

Human   586 FSHAKQLFAACLELVTEFSPKLRQVMLNEMLLLDIHTHEAGTGQAGERPPSDLISRVRGYLEMRL 650
            :..||||.:||||||||||||||||||||||||||:||||..||  ||||.|||||||||||||:
 Frog   585 YPRAKQLLSACLELVTEFSPKLRQVMLNEMLLLDIYTHEASIGQ--ERPPPDLISRVRGYLEMRI 647

Human   651 PDIPLRQVIAEECVAFMLNWRENEYLTLQVPAFLLQSNPYVKLGQLLAATCKELPGPKESRRTAK 715
            ||||||||::||||||:||||||||||||||..|:|:|||||||||||||||||||| :||||||
 Frog   648 PDIPLRQVVSEECVAFLLNWRENEYLTLQVPPALVQNNPYVKLGQLLAATCKELPGP-DSRRTAK 711

Human   716 DLWEVVVQICSVSSQHKRGNDGRVSLIKQRESTLGIMYRSELLSFIKKLREPLVLTIILSLFVKL 780
            |||||||||||||:||||.|||||.|||.|:||:||:||:||:||:||||||||||.:|||||||
 Frog   712 DLWEVVVQICSVSNQHKRANDGRVCLIKNRDSTMGILYRNELVSFVKKLREPLVLTTLLSLFVKL 776

Human   781 HNVREDIVNDITAEHISIWPSSIPNLQSVDFEAVAITVKELVRYTLSINPNNHSWLIIQADIYFA 845
            ||:|||||||||||||:||||.|||||:|||:|||:||:|||.|.|:||.|:||||.||||||||
 Frog   777 HNLREDIVNDITAEHITIWPSCIPNLQAVDFDAVAVTVRELVSYALTINSNSHSWLTIQADIYFA 841

Human   846 TNQYSAALHYYLQAGAVCSDFFNKAVPPDVYTDQVIKRMIKCCSLLNCHTQVAILCQFLREIDYK 910
            ||:|||||:|||||||||||||.|.|||:|||||||||||||||:|||||.||||||||||||||
 Frog   842 TNEYSAALNYYLQAGAVCSDFFTKQVPPEVYTDQVIKRMIKCCSMLNCHTHVAILCQFLREIDYK 906

Human   911 TAFKSLQEQNSHDAMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNASNPEEVL 975
            ||||:||||||||.|||||||||||||||||||||||||||||||||||||||||||:|||||||
 Frog   907 TAFKALQEQNSHDGMDSYYDYIWDVTILEYLTYLHHKRGETDKRQIAIKAIGQTELNSSNPEEVL 971

Human   976 QLAAQRRKKKFLQAMAKLYF 995
            |||||||||||||:||||||
 Frog   972 QLAAQRRKKKFLQSMAKLYF 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INTS8	NP_060334.2	WFEF motif. /evidence=ECO:0000269|PubMed:32966759	24..29		4/4 (100%)
		TPR 1	250..288		25/37 (68%)
		TPR 2	320..356		16/35 (46%)
		TPR 3	570..603		23/32 (72%)
		TPR 4	833..866		29/32 (91%)
ints8	NP_001090873.1	None