Protein Alignment OSGEP and KAE1

DIOPT Version :10

• Sequence 1: NP_060277.1
• Gene: OSGEP / 55644
• HGNCID: 18028
• Length: 335
• Species: Homo sapiens
• Sequence 2: NP_012964.2
• Gene: KAE1 / 853910
• SGDID: S000001746
• Length: 386
• Species: Saccharomyces cerevisiae
• Alignment Length: 368
• Identity: 226/368 - (61%)
• Similarity: 267/368 - (72%)
• Gaps: 37/368 - (10%)

Human     5 LGFEGSANKIGVGVVR----------------DGKVLANPRRTYVTPPGTGFLPGDTARHHRAVI 53
            ||.||||||:|||:|:                :.::|:|.|.|||||||.||||.|||||||...
Yeast    19 LGLEGSANKLGVGIVKHPLLPKHANSDLSYDCEAEMLSNIRDTYVTPPGEGFLPRDTARHHRNWC 83

Human    54 LDLLQEALTESGLTSQ--DIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEM 116
            :.|:::||.|:.:.|.  |||.|.:||||||||||.||.:.|||.:.||:.||||||||||||||
Yeast    84 IRLIKQALAEADIKSPTLDIDVICFTKGPGMGAPLHSVVIAARTCSLLWDVPLVGVNHCIGHIEM 148

Human   117 GRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIE 181
            ||.||.|.:|.||||||||||||||||.||||||||:|||:|||||||||.|||.|:||||||||
Yeast   149 GREITKAQNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFARTLKIPNEPSPGYNIE 213

Human   182 QMAKRG---KKLVELPYTVKGMDVSFSGILSFIEDVAHRML------------ATGE--CTPEDL 229
            |:||:.   :.||||||||||||:|.||||:.|:.:|..:.            .|||  .|.|||
Yeast   214 QLAKKAPHKENLVELPYTVKGMDLSMSGILASIDLLAKDLFKGNKKNKILFDKTTGEQKVTVEDL 278

Human   230 CFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQER-GARLFATDERFCI 293
            |:||||.:||||||||||||||..|.:.|||||||||||||||||.||::| ..::.|||.||||
Yeast   279 CYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQEMMAQMCKDRANGQVHATDNRFCI 343

Human   294 DNGAMIAQAGWEMFRAGHRT-PLSDSGVTQRYRTDEVEVTWRD 335
            |||.||||||...:|.|... ..|::.|||::|||||...|||
Yeast   344 DNGVMIAQAGLLEYRMGGIVKDFSETVVTQKFRTDEVYAAWRD 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OSGEP	NP_060277.1	ASKHA_NBD_OSGEP_like_euk	4..310	CDD:466982	213/340 (63%)
KAE1	NP_012964.2	ASKHA_NBD_OSGEP_like_euk	17..360	CDD:466982	213/340 (63%)