Protein Alignment CHD7 and CHD1

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_011091.1
• Gene: CHD1 / 856911
• SGDID: S000000966
• Length: 1468
• Species: Saccharomyces cerevisiae
• Alignment Length: 1634
• Identity: 455/1634 - (27%)
• Similarity: 725/1634 - (44%)
• Gaps: 385/1634 - (23%)

Human   602 KNNHIVAEDPSKGFGKDDFPGGVDN-QELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEP 665
            :.:|..|......|...|.....|| ::..|..:...::::.:.:..:.::|..|.::.::.:|.
Yeast    20 RRSHRAAAHQQNYFNDSDDEDDEDNIKQSRRKRMTTIEDDEDEFEDEEGEEDSGEDEDEEDFEED 84

Human   666 KE----PKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSD 726
            .:    |......| ||...:.|:| :.||.:|.|:|:.|.|...::...|.||    ...:.||
Yeast    85 DDYYGSPIKQNRSK-PKSRTKSKSK-SKPKSQSEKQSTVKIPTRFSNRQNKTVN----YNIDYSD 143

Human   727 LDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQ 791
            .|..       |.::|.|.::                  .:|:|...:|.|        ..|.|.
Yeast   144 DDLL-------ESEDDYGSEE------------------ALSEENVHEASA--------NPQPED 175

Human   792 QESVD-----------AEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIED 845
            ...:|           .||.|:||.:...:..|        |..||.:|:.:.|:||..|.:.|.
Yeast   176 FHGIDIVINHRLKTSLEEGKVLEKTVPDLNNCK--------ENYEFLIKWTDESHLHNTWETYES 232

Human   846 LEKD---KRIQQKIKRFKAKQGQNKF----------LSEIEDELFNPDYVEV---DRIMDFARST 894
            :.:.   ||:....|:|..:..|.:.          :.::|.|....::.|.   :||:|..|::
Yeast   233 IGQVRGLKRLDNYCKQFIIEDQQVRLDPYVTAEDIEIMDMERERRLDEFEEFHVPERIIDSQRAS 297

Human   895 DDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLMSRE----------------PETE 943
            .:.|.....|||||..|.|:::|||...||.:...|:.:...:||                |..|
Yeast   298 LEDGTSQLQYLVKWRRLNYDEATWENATDIVKLAPEQVKHFQNRENSKILPQYSSNYTSQRPRFE 362

Human   944 RVE-RPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFL 1007
            ::. :||            :....:||::||.|:||:.|.|....|.|||||||||||:|::.|:
Yeast   363 KLSVQPP------------FIKGGELRDFQLTGINWMAFLWSKGDNGILADEMGLGKTVQTVAFI 415

Human  1008 -YEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFKDPQGRV 1070
             :.|:.:..:||.:::.||||:|.|...|..|. :||.:.|.|:|.||.||:.||.| .:|:.:.
Yeast   416 SWLIFARRQNGPHIIVVPLSTMPAWLDTFEKWAPDLNCICYMGNQKSRDTIREYEFY-TNPRAKG 479

Human  1071 IKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGT 1135
             |.:.||:.::||:|.||.|..||.:|.|:.:.:||||||||....|.|.|....:.:::|:|||
Yeast   480 -KKTMKFNVLLTTYEYILKDRAELGSIKWQFMAVDEAHRLKNAESSLYESLNSFKVANRMLITGT 543

Human  1136 PLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAP 1200
            ||||.::||.:|::||.|.||..:.....|..|.:.||.:..|...::|.:|||||:||||:|..
Yeast   544 PLQNNIKELAALVNFLMPGRFTIDQEIDFENQDEEQEEYIHDLHRRIQPFILRRLKKDVEKSLPS 608

Human  1201 KEETIIEVELTNIQKKYYRAILEKNFTFLSKG--GGQANVPNLLNTMMELRKCCNHPYLINGAEE 1263
            |.|.|:.|||:::|.:||:.||.||::.|:.|  ||..   :|||.|.||:|..|||||.:.|||
Yeast   609 KTERILRVELSDVQTEYYKNILTKNYSALTAGAKGGHF---SLLNIMNELKKASNHPYLFDNAEE 670

Human  1264 KILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQ 1328
            ::|::|.:  ...:.:..|:.:|.::||:||:|:||.:||..||||||||||||.||||.|||..
Yeast   671 RVLQKFGD--GKMTRENVLRGLIMSSGKMVLLDQLLTRLKKDGHRVLIFSQMVRMLDILGDYLSI 733

Human  1329 RRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQND 1393
            :...::|:||.|....|:.:||.|:.|||:.|||||.||||||||||..|||.:|||||||||.|
Yeast   734 KGINFQRLDGTVPSAQRRISIDHFNSPDSNDFVFLLSTRAGGLGINLMTADTVVIFDSDWNPQAD 798

Human  1394 LQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKK 1458
            |||.||.|||||...|.:|||:::::.|.|:.::|..|:.|:.|::..     ..|:|.:...|.
Yeast   799 LQAMARAHRIGQKNHVMVYRLVSKDTVEEEVLERARKKMILEYAIISL-----GVTDGNKYTKKN 858

Human  1459 -----EIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITI----ESEGKGSTFAKASF 1514
                 |:..:|:.|| |.:....|...|..:.::|.:|......:|.    ||...|..|.| .|
Yeast   859 EPNAGELSAILKFGA-GNMFTATDNQKKLEDLNLDDVLNHAEDHVTTPDLGESHLGGEEFLK-QF 921

Human  1515 VASGNRTDISLDD--PNFWQKWAKKAELD-------------IDALNGRNNLVIDTPRVRKQTRL 1564
            ..:..:.||..||  |   ::..||.:.:             ::.:|.|:|.:         .::
Yeast   922 EVTDYKADIDWDDIIP---EEELKKLQDEEQKRKDEEYVKEQLEMMNRRDNAL---------KKI 974

Human  1565 YSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGR 1629
            .::|..|.....||.:.||..:...:..|..|..
Yeast   975 KNSVNGDGTAANSDSDDDSTSRSSRRRARANDMD------------------------------- 1008

Human  1630 YKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRK 1694
               .:.|.:|..:.:.||.:        .|:|..:.:||   |||           :.||
Yeast  1009 ---SIGESEVRALYKAILKF--------GNLKEILDELI---ADG-----------TLPV----- 1043

Human  1695 GKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHL-----KHHCNNSGNNATDQLYVLASCDL 1754
                  :|.:...:..|.:.....|.:.:|:..:|.:     ||        ||.....|.|.::
Yeast  1044 ------KSFEKYGETYDEMMEAAKDCVHEEEKNRKEILEKLEKH--------ATAYRAKLKSGEI 1094

Human  1755 EQVIQPLEDSLS-------------------------WVLLRVRMLYYLRQEVIGDQADKILEGA 1794
            :...||.::.|:                         .:|.||..|.||:..:..:..|..|:.:
Yeast  1095 KAENQPKDNPLTRLSLKKREKKAVLFNFKGVKSLNAESLLSRVEDLKYLKNLINSNYKDDPLKFS 1159

Human  1795 DSSEADVWIPEPFHAEVPADW---WDKEADKSLLIGVFKHGYEKYNSMRADPAL-----CFLERV 1851
            ..:..    |:|..     :|   |.||.|:.|||||||:||..:..:|.||.|     .||..|
Yeast  1160 LGNNT----PKPVQ-----NWSSNWTKEEDEKLLIGVFKYGYGSWTQIRDDPFLGITDKIFLNEV 1215

Human  1852 GMPDAKAIAAEQ---------------------------RGTDML--------------ADGGD- 1874
            ..|.||..|:..                           |..|.|              ||.|.
Yeast  1216 HNPVAKKSASSSDTTPTPSKKGKGITGSSKKVPGAIHLGRRVDYLLSFLRGGLNTKSPSADIGSK 1280

Human  1875 ----GGEFDREDEDPEYKPTRTPFKDEI--DEFANSPSEDKEESME------IHAT--------- 1918
                |....|:.:...:..:.||   ||  .|.||.|...:.:::.      |:.|
Yeast  1281 KLPTGPSKKRQRKPANHSKSMTP---EITSSEPANGPPSKRMKALPKGPAALINNTRLSPNSPTP 1342

Human  1919 ----------GKHSESNAELGQLYWPNTSTLTTR-LRRLITAYQRSYKRQQMRQEALMKTDRRRR 1972
                      |....||...|..:.....::... .|..::|.:.|.||.:...::|   ||
Yeast  1343 PLKSKVSRDNGTRQSSNPSSGSAHEKEYDSMDEEDCRHTMSAIRTSLKRLRRGGKSL---DR--- 1401

Human  1973 RPREEVRALEAEREAIIS--EKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDK 2035
              :|..:.|:.|...|.:  |.::..:|:...:.||              :..|:....|...|.
Yeast  1402 --KEWAKILKTELTTIGNHIESQKGSSRKASPEKYR--------------KHLWSYSANFWPADV 1450

Human  2036 KSDESLEKY 2044
            ||.:.:..|
Yeast  1451 KSTKLMAMY 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	20/78 (26%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	19/59 (32%)
		PLN03142	967..>1566	CDD:215601	255/626 (41%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
CHD1	NP_011091.1	CD1_tandem_CHD1_yeast_like	175..247	CDD:349312	18/79 (23%)
		CD2_tandem_ScCHD1_like	283..341	CDD:349311	19/57 (33%)
		PLN03142	363..>961	CDD:215601	254/626 (41%)
		Cdh1_DBD_1	1010..1129	CDD:408024	27/159 (17%)
		SANT_TRF	1175..>1204	CDD:212558	16/28 (57%)
		DUF4208	1368..1460	CDD:464035	22/114 (19%)