Protein Alignment CHD7 and dom

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_001286676.1
• Gene: dom / 45655
• FlyBaseID: FBgn0020306
• Length: 3233
• Species: Drosophila melanogaster
• Alignment Length: 3782
• Identity: 660/3782 - (17%)
• Similarity: 1125/3782 - (29%)
• Gaps: 1552/3782 - (41%)

Human    95 GNGLASPHSQYH--TPPVPQ--VPH------------------GGSGGGQMGVYPGMQNERH--- 134
            ||.....|....  .|.||.  .||                  .||.|..:   |..::.:|
  Fly     4 GNSAGGGHEGLSPAPPAVPDRVTPHSTEISVAPANSTSTTVRAAGSVGAAL---PATRHHQHIAT 65

Human   135 -GQSFVDSSSMWGPRAVQVPDQIRAPYQQQQPQPQPPQPAPSGPPAQGHPQHMQQMGSYMARGDF 198
             .:....|||....:....  |:..|.   .|.||..|.......|...|.|     |.::....
  Fly    66 QVKGIASSSSKQQKQLASA--QLPVPL---SPLPQQQQQTAEATAAAAAPAH-----SNVSVSSS 120

Human   199 SMQQHGQPQQRMSQFSQGQEGLNQGNPFIATSGPGHLSHVPQQSPSMAPSLRHSVQQFHHHPSTA 263
            :::....|.|...|.....|........:   ||...|::..   |:.|:...|..:.....|||
  Fly   121 TIEASVLPPQAKRQRLDDNEDRTSAASIV---GPAESSNIVS---SLLPASVASSSEVGGLSSTA 179

Human   264 L------------------------------------HGESVAHSPRFSPNPPQQGAVRPQTLNF 292
            |                                    :|.|:...|.:....|     .||.:::
  Fly   180 LQDLNALKKRILQQKLQILRNLKERHLENVSEYFYLQNGGSMMDYPAWRKKTP-----TPQFISY 239

Human   293 SS-----------RSQTVPSPTINNSGQYSRYPYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPR 346
            |:           :..|..:.....:.:|:.....::...||:..|    .|.|...|::.::
  Fly   240 SNANRIDQLIHEDKPSTSAAAAAAQNQKYTTQQTDSVESSLVSGIG----TGATKGAPLDGNI-- 298

Human   347 YPNAVGFPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPP 411
                                   |.|..:.|||:..||: .|::..   .:|....||.:.|.|.
  Fly   299 -----------------------SNSTVKTNTQSQVPSK-IGSFTE---STPAATESNSSTTVPG 336

Human   412 QVRPGSAGIPMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPFIGMSSAPRELTGHM- 475
            ....|:|                                           ...|:...|.:|::
  Fly   337 TATSGAA-------------------------------------------TSTSATSAEASGNVL 358

Human   476 ---RPNGCPGVGLGDPQAIQERL------------IPGQQHPGQQPS-FQQLPTCPPLQPHPGLH 524
               .....|.|| ..|.||..:|            |||:...|:... |.|:|..|....:|
  Fly   359 AVEAEIKIPAVG-ATPVAISTKLPAAVVQLTQQGHIPGRPLGGRHGMVFGQIPAPPAAVGNP--- 419

Human   525 HQSSPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLE--------KPVPDMTQVSGPNAQLV 581
              |.|..|...|....:.|..:|..:.|..|::.|.....        .|.|..|. :|| |.|.
  Fly   420 --SVPLVPGGTPLLPCNTSAGSTALRRPQGQNNASSGSAAASGGGGSLTPTPLYTG-NGP-AALG 480

Human   582 KSDDYLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNSLDGSQEEKKKKKR 646
            .|....|.          ...:..:::  |:.|.|     .|..|......|....||....::.
  Fly   481 GSGGLTPG----------TPTSGSLLS--PALGGG-----SGTPNSAAQEFSFKAKQEVYVMQRI 528

Human   647 SKAKKD--------PK--EPKEPK------------------EKKEPKEPKTPKAPKIPKEPKEK 683
            |:.:::        ||  ||..||                  ::::.|:....|..|:.::..:.
  Fly   529 SELQREGLWTERRLPKLQEPSRPKAHWDYLLEEMVWLAADFAQERKWKKNAAKKCAKMVQKYFQD 593

Human   684 KAKTATPKPKSSK---------------------------KSSNKKPDSEASAL----------K 711
            ||..|....|:.:                           |...|..:....||          .
  Fly   594 KATAAQRAEKAQELQLKRVASFIAREVKSFWSNVEKLVEYKHQTKIEEKRKQALDQHLSFIVDQT 658

Human   712 KKVNKGKTEGSENSDLDK--------TPP---------PSPPPEEDEDPGVQKRRSSRQVKRK-- 757
            :|.::...||...|..|.        |.|         |....|:||:...:....:..||.:
  Fly   659 EKFSQQLVEGMNKSVADTPSLNSSRLTSPKRESDDDFRPESGSEDDEETIAKAEEDAADVKEEVT 723

Human   758 -------------------RYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQESVDAEGPVVE 803
                               .|.|:.: |:..||...|........|:.|:.|.:|:.|.:
  Fly   724 ALAKESEMDFDDFLNDLPPGYLENRD-KLMKEEQSSAIKTETPDDSDDSEFEAKEASDDD----- 782

Human   804 KIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDK--RIQQKIKRFKAKQ--- 863
                ..::.||:|:.:|::.::                .|::||.|.  .::|.:.::|::|
  Fly   783 ----ENTISKQEEAEQEIDHKK----------------EIDELEADNDLSVEQLLAKYKSEQPPS 827

Human   864 GQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAK 928
            .:.:.|:..:.||                .:||....|             |||    ::.:.|.
  Fly   828 PKRRKLAPRDPEL----------------DSDDDSTAV-------------DST----EESEDAA 859

Human   929 IEEFEKLMSREPETERVERPPADDWKKS----------------------------------ESS 959
            .|:.|.|.:.:.:|:..|:...:|..||                                  ..|
  Fly   860 TEDEEDLSTVKTDTDMEEQDEQEDGLKSLMADADATSGAAGSGSTAGASGNKDDMLNDAAALAES 924

Human   960 REYKNN----------------NKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLY 1008
            .:.|.|                :.|||||..|::||:.......|.|||||||||||||:|..|.
  Fly   925 LQPKGNTLSSTNVVTPVPFLLKHSLREYQHIGLDWLVTMNERKLNGILADEMGLGKTIQTIALLA 989

Human  1009 EI-YLKGIHGPFLVIAPLSTIPNWEREFRTWTE-LNVVVYHGSQASRRTIQLYEMYFKDPQGRVI 1071
            .: ..||..||.|::.|.|.:.|||.||:.|.. ..::.|:|||..|:   |..:.:..|..
  Fly   990 HLACAKGNWGPHLIVVPSSVMLNWEMEFKKWCPGFKILTYYGSQKERK---LKRVGWTKPNA--- 1048

Human  1072 KGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKVLLTGTP 1136
                 ||..||::::::.|....|...|:.:::|||..:||...:..:.|.....|.::||||||
  Fly  1049 -----FHVCITSYKLVVQDQQSFRRKKWKYLILDEAQNIKNFKSQRWQLLLNFSTERRLLLTGTP 1108

Human  1137 LQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT----------EEQVQKLQAILKPMMLRRLK 1191
            |||.:.||:||:|||.|..|.|...|.:.|.:..|          |..:.:|..:::|.:|||||
  Fly  1109 LQNDLMELWSLMHFLMPYVFSSHREFKEWFSNPMTGMIEGNMEYNETLITRLHKVIRPFLLRRLK 1173

Human  1192 EDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFT--FLSKGGGQANVPNLLNTMMELRKCCNH 1254
            ::|||.:..|.|.:|...|:|.|:..|...:.:..|  .|..|    |:.:::|.:|:|||.|||
  Fly  1174 KEVEKQMPKKYEHVITCRLSNRQRYLYEDFMSRAKTRETLQTG----NLLSVINVLMQLRKVCNH 1234

Human  1255 PYLI------------------------------------------------------------- 1258
            |.:.
  Fly  1235 PNMFEARPTISPFQMDGITFHTPRLVCDIMEYDPFTQINLETLNLLLLHLEQTMTAYVSHKSRLL 1299

Human  1259 ---------------------NG------------------------------------------ 1260
                                 ||
  Fly  1300 APPRKLIEDIDTAPLPAPRCPNGKYRFHIRVRSAELAQRIKLNAVKVGASPAMRLEGSKIMPMRN 1364

Human  1261 --------------------------------------------------AEEKIL--------- 1266
                                                              :..|:|
  Fly  1365 LLPSGRVLKRVSASINPVNMALKPVVINSVVTTTSSSTTASSPTGALSVLSNSKLLGARSQINAP 1429

Human  1267 ----------------------------------------------------------------- 1266
                                                                             
  Fly  1430 TPAKVAKTMQDGKPFFYLTPATNSGAAGARLTLTSKTTASASTTTSRTTVTASTTSGQQLIRDPI 1494

Human  1267 ---------------------EEFKETHNAESPDFQLQAMIQA---------------------- 1288
                                 .|.:|...||.| :::|.:||.
  Fly  1495 VKDLATHVKSTVQKQSIANGKTEPEEETEAEDP-YKVQELIQMRKEQRLAALKRMAMINRRRTDA 1558

Human  1289 ----------------------------------------------------------------- 1288
                                                                             
  Fly  1559 TPIYGEDCREAIQRCMQATRSLKRSTWQTRGYANCCTAMAHRNGWSLNHLLKSFEERCADLKPVF 1623

Human  1289 ----------------------------------------------------------------- 1288
                                                                             
  Fly  1624 ANFVIYVPSVCAPRIRRYVQNLSSTHWQHEQRIENIVDQALRPKLALLHPIISEMTTKFPDPRLI 1688

Human  1289 ---AGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAID 1350
               .|||..:|:||.:||..|||||||:||.:.||:||.:|....:.|.|:||..|...||..::
  Fly  1689 QYDCGKLQTMDRLLRQLKVNGHRVLIFTQMTKMLDVLEAFLNYHGHIYLRLDGSTRVEQRQILME 1753

Human  1351 RFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLI 1415
            ||: .|...|.|:|.||:||:|||||.|||.|.:||||||..|.|||.|||||||::.|.||||:
  Fly  1754 RFN-GDKRIFCFILSTRSGGVGINLTGADTVIFYDSDWNPTMDAQAQDRCHRIGQTRDVHIYRLV 1817

Human  1416 TRNSYEREMFDKASLKLGL-DKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEG 1479
            :..:.|..:..||:.|..| |.|:       |.............|:||     :.....|:||.
  Fly  1818 SERTIEVNILKKANQKRMLSDMAI-------EGGNFTTTYFKSSTIKDL-----FTMEQSEQDES 1870

Human  1480 SKFCEEDIDQIL----LRRTHTITIESEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKKAEL 1540
            |:...|:.|:|:    |..|.:..:|:|.:.....:.:..|:.:..|:..         .|.|:.
  Fly  1871 SQEKSENKDRIVATTTLSDTPSTVVETEKQSLRAFEHALAAAEDEQDVQA---------TKTAKA 1926

Human  1541 DIDALNGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSE 1605
            ::.|                           :|.||.:....:.|.|.|:
  Fly  1927 EVAA---------------------------DLAEFDENIPIATEDPNAE--------------- 1949

Human  1606 CFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITP 1670
                                  |..:.:|::.|:|         ..|..|....|:.:....:..
  Fly  1950 ----------------------GGPQVELSKADLE---------MQNLVKQLSPIERYAMRFVEE 1983

Human  1671 TADGQTRALVNHSGLSAPVPRGRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHC 1735
            |....|                  .::::|...:...|..:|.|: ...|:.:|:..
  Fly  1984 TGAAWT------------------AEQLRAAEAELEAQKREWEAN-RLAAMHKEEEL-------- 2021

Human  1736 NNSGNNATDQLYVLASCDLEQVIQPLEDSLSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEAD 1800
                              |:|..:..|           ||.|.|:              |||. .
  Fly  2022 ------------------LKQETEAEE-----------MLTYSRK--------------DSSN-Q 2042

Human  1801 VWIPEPFHAEVPADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCF---LERVGMPDAKAIAAE 1862
            |||......::|. |......:           :..|.:..|.:|.|   ||.:...|...:...
  Fly  2043 VWISRNTMEQMPM-WCPPTPPQ-----------DNDNDIYIDYSLSFMYELEPIAETDLPPVYVR 2095

Human  1863 QRGTDMLADGG-DG----GEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEE--------SME 1914
            :.......|.| ||    .:..|||   .|.|.|:.|.....:.|....|.|.:        :|.
  Fly  2096 KEHKRSRTDAGYDGSRRPNKMRRED---NYVPPRSLFDRPTPQLARLRRELKSQRFRGSFKPNMP 2157

Human  1915 IHATG--------KHSESNAEL---------------------------GQLYWPNTSTLTTRLR 1944
            |....        ...|:.||.                           ||.  ||.. |.:.:.
  Fly  2158 IPGLKPQLPTKPLTEPEAMAEWCVFEDMAILHVLVNLQGLPCSLMLLSPGQT--PNWD-LVSEMV 2219

Human  1945 RLITAYQRSYKRQQMRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREE-------- 2001
            ...:...||.::.:.|.|..:       :||||.:.:|:.::    :|:.|.|.|.|
  Fly  2220 NFCSKTYRSARQCRWRYETHI-------QPREEGKVVESPKK----QKKLKPTLRTEYLKSPLRY 2273

Human  2002 ------------ADFYRVVSTFGVIFDPVKQQF------DWNQFRAFARLDKKSDESLEKY---- 2044
                        |.||:   |....||.:|..:      ...||.|.:.::.|..|.|:::
  Fly  2274 LRTTQLYVSDNNASFYK---TMRSRFDSIKTAYLKKAPPPKRQFSAPSLMNPKHMEVLQEFGILN 2335

Human  2045 FSCFVAMCRRVCRMPVKPDD-------------------EPPDLSSIIE---------------P 2075
            :.           .||.|.:                   :||....:::               |
  Fly  2336 YD-----------QPVSPQNIAAMKANKIREKQRGQQMSQPPVGVGVVQQMQQQSQQQQQPAPPP 2389

Human  2076 ITEERASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVS 2140
            :.:::..:     ::::::::|.....|..::..:.|   .||.
  Fly  2390 LPQQQQPQ-----QVVQQVQQQQQQQQQQQQQQVVQQ---QLPT--------------------- 2425

Human  2141 RTDYHILNDPELSFLDAHKNFAQNRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVL--EQAEG 2203
                 :.|..:...:.......|.:....|:...|.|.|.:|.   :...|:....|.  :|...
  Fly  2426 -----VSNVQQTLPVQQTVELVQQQPTTTTTVAVPAAGGQLQQ---LQIQHLTSSNVSPGQQTAI 2482

Human  2204 KVEEPENPAAKEKCEGKEEEEE-------------TDGSGKESKQECEAEASSVKNELKGV---- 2251
            .:.:|:........:|.:...:             |.|..::..|: .|.||..::.:..|
  Fly  2483 LLHQPQQQLRTHPGQGGQSNTQQLVKTIVGTSSSLTAGQLQQLAQQ-SAVASGGQSSVSVVLTTP 2546

Human  2252 ----------EVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDEESNASM 2306
                      ::|:.....|||.:              ....:|.|:.|::.:.::..:.  .|:
  Fly  2547 VQTLPSVVQPQIGSGAQIVSISSQ--------------TLPVNSSPQLGSIVQTQSLPQV--VSV 2595

Human  2307 STARDETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVNRRQMFD 2371
            ||.              |:|..:|  .|.|..  |:.:.....:..:...:|:|:..|:
  Fly  2596 STL--------------PTVGTVL--TTTANQ--PQQQHQTTAVTTLNTTMLRGQRIVS------ 2636

Human  2372 FQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQRRRRRRK 2436
                      |...:.||:|:.|           |.:.|.:.|.|.:.     :.|.|.:.:.|.
  Fly  2637 ----------TAAGNTLQQRTTA-----------GGQSIVSMPNLGQG-----ASPSQFQTQLRL 2675

Human  2437 IEIEAERAAKRRNLMEM----VAQLRES------QVVSENG---------------QEKVVDLSK 2476
            ..:....|.:...|:..    |:.|::.      .|..::|               |.....:..
  Fly  2676 AAVPTSPATQTTQLVTTKGIPVSALQQGGKTTVIPVTQQSGGAHIQLYRQRSLKVLQTTTQAVPS 2740

Human  2477 ASREATSSTSNFSSLSSKFI-LPNVSTPVSDAFKTQMELLQAGLSRTPTRHLLNGSLVD------ 2534
            .|..||.:|:|........| ..|::|.|     |..::..:|:..|.|. :..|::|.
  Fly  2741 GSAGATGATANLVQAGGTIIQASNMATHV-----TSQKVAVSGMPGTSTT-VQAGNVVSSVQMHG 2799

Human  2535 ------------GEPPMKRR----RGRRKNVEGLDLLFMSHKRTSLSAEDAE-------VTKAFE 2576
                        |:..::|:    .|........|:|.:. :...|:|:.|:       .|...:
  Fly  2800 QARTQFIKQMAAGKQQLQRQVVSADGTTTTTAAGDMLLVK-RHNILAAQKAQQASGALFTTTTGQ 2863

Human  2577 EDIETPPTRNIPSPGQLDPDTRIPVINL-EDGTRLVGEDAPKNKDLVEWLKLHPT-----YTVDM 2635
            :..:......:|..||....|:..:.:| :..|......:..|...|.....:||     ..:.:
  Fly  2864 QQQQQQQQGQLPVAGQPQQVTQHQIASLVKASTAAAASGSSVNAGGVTVSATNPTVQAGSVNMTL 2928

Human  2636 PSYVPKNADVLFSSFQKPKQKRH-----RCRNPNKL----------------DINTLTGEER--- 2676
            |...|.:.    .....|.|.||     :...|.|:                :|.|.||.::
  Fly  2929 PQLKPGSQ----IKVTMPNQMRHLQMQQQLTMPRKISRMTQLVSASGQPTATNIITTTGPQQQQQ 2989

Human  2677 ---------VPVV-----NKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSG---- 2723
                     :|.|     .:::.:|:||..:...:.|.....:....:|.......|.:||
  Fly  2990 GVTVSGGGTLPTVASQQQQQQHQQKVGGGNSVQAQLLHIQNTKGLSNSVTMQQIQQVMRSGQQGT 3054

Human  2724 -FVPESMFDRLLTGPVVRGEGASRRGRRPKSEIARAAAAAA-------------AVAST------ 2768
             .....:..:...|.|:....||:..:|...::..||:|.|             ::|||
  Fly  3055 LATTNLVLGKTSVGRVIPVSVASQANQRQTIQVVSAASAQALAAGNLRTHVAGPSIASTLKVAAP 3119

Human  2769 ---------------------SGINPLLVNSLFAGMDLTSLQNLQNLQSLQLAGLMGFPPGLATA 2812
                                 ...:|:.:.:...|..|..:|..|..|...:||
  Fly  3120 GSAGGQTTQQTLIAALQHNQRQNASPVRLQTTAGGNLLAVVQQQQQQQHTSIAG----------- 3173

Human  2813 ATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPLSAATGNTTTASSQGEPEDSTSKGEEKG 2877
            .|||     ||.|:.:                         |..|||..:.|..:....:.:::|
  Fly  3174 PTAG-----PAEVMTI-------------------------TQTTTTLPTVGSLQQQQQQQQQQG 3208

Human  2878 NENEDENKDSEK 2889
            ..::...:...|
  Fly  3209 GISQPTTQQVRK 3220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830	77/452 (17%)
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	10/66 (15%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	9/56 (16%)
		PLN03142	967..>1566	CDD:215601	220/1041 (21%)
		BRK	2593..2634	CDD:462196	7/46 (15%)
		BRK	2672..2716	CDD:197800	9/60 (15%)
dom	NP_001286676.1	HSA	543..614	CDD:214727	13/70 (19%)
		HepA	692..>1235	CDD:440319	158/616 (26%)
		DEXQc_SRCAP	949..1171	CDD:350761	84/232 (36%)
		SF2_C_SNF	1685..1817	CDD:350180	69/132 (52%)
		DISARM_DrmD_b	<1702..>1936	CDD:468472	94/282 (33%)
		HEC1	<1858..>2031	CDD:444066	42/315 (13%)
		SP1-4_N	2486..>2819	CDD:425404	63/405 (16%)