Protein Alignment CHD7 and brm

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Alignment Length: 2035
• Identity: 515/2035 - (25%)
• Similarity: 791/2035 - (38%)
• Gaps: 586/2035 - (28%)

Human    98 LASPHSQYHTPPVPQVPHGGSGGGQMGVYPGMQNERHGQSFVDSSSMWGPRAVQVPDQIRAPYQQ 162
            :|||.......|.||.|                           |.|..|.....|.. .:||..
  Fly     1 MASPSPANSPMPPPQAP---------------------------SPMAPPSQSPAPSP-HSPYPH 37

Human   163 QQPQPQPPQPAPSGPPAQGHPQHMQQMGSYMARGDFSMQQHGQPQQ-----RMSQFSQGQEGLNQ 222
            |||.|....|.|..|.|.|||                 .|||.|.|     .|....||
  Fly    38 QQPGPLQGPPPPGHPGAYGHP-----------------MQHGPPGQGPPGHHMPPHHQG------ 79

Human   223 GNPFIATSGPGHLSHVPQQSPSMAPSLRHSVQQFHHHPSTALHGESVAH--SPRFSPNPPQQGAV 285
               .|.:.||    |:..|.|...|::  |..|.|..|..|.....:..  .|...|.||::.:
  Fly    80 ---MIFSKGP----HMGMQMPPTGPNM--SPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSS- 134

Human   286 RPQTLNFSSRS-QTVPSPTINNSGQYSRY-------PYSNLNQGLVN--NTGMNQNLGLTNNTPM 340
             .:.|:...|: .::....:....:||:.       .:.:||...||  .|.:.....|..|.|:
  Fly   135 -QENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPI 198

Human   341 NQSVPRYPNAVGFPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNP 405
            :..:.:...|.           .|||  |.|.          |..|.|....|||      .|..
  Fly   199 SMQMQQALQAA-----------QQQP--PPGP----------PIGPPGAPGGPPP------GSQH 234

Human   406 AGTP--PPQVR---PGSAGIPMEVGSYPNMPHPQPSHQPPGAMGIGQRNM---GPRNMQQSRPFI 462
            ||.|  |||.:   |.|||.|      |....| |:..|.|....||:..   .|.:|||.:|.
  Fly   235 AGQPPVPPQQQQQPPPSAGTP------PQCSTP-PASNPYGPPVPGQKMQVAPPPPHMQQGQPL- 291

Human   463 GMSSAPRELTGHMRPNGCPGVGLGDPQAIQERLIPGQQHPGQQPSFQQLPTCPPLQPHPGLHHQS 527
                          |...|.|  |.|..||::..|.||....||        ||.:||   .||.
  Fly   292 --------------PPQPPQV--GGPPPIQQQQPPQQQQQQSQP--------PPPEPH---QHQL 329

Human   528 SPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLEKPVPDM---TQV----SGPNAQLVKSDD 585
                |:......:.||...     |:...||.:|.:...:|.|   :||    .||..|:..:..
  Fly   330 ----PNGGKPLSMGPSGGQ-----PLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGM 385

Human   586 YLPSIEQQPQQKKKKKKNNHI--VAEDPSKGFGKDDFPGGVD---------NQELNRNSLDGSQE 639
            .:|             |.|.|  ||:           |.|:|         |:...|.||
  Fly   386 PMP-------------KPNRITTVAK-----------PVGLDPITLLQERENRIAARISL----- 421

Human   640 EKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKSSNKKPD 704
                 :..:.::.|....|....:...|.:..:.....::.:.:..: .|.:..:.:.:.|.|
  Fly   422 -----RMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQ-CTRRDTTLETALNIK-- 478

Human   705 SEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISD 769
                ..|:...:|..|......|:|                   :...:.:|||..:.|||..:.
  Fly   479 ----LYKRTKRQGLREARATEKLEK-------------------QQKLEAERKRRQKHLEFLAAV 520

Human   770 -EEADDADAAGRDSPSNTSQSEQ---QESVDAEGPVVEKIMSSRSVKKQKESGEE-------VEI 823
             :...|.....|::.:..::..:   ....:||          |..||::|..|:       .|.
  Fly   521 LQHGKDLREFHRNNKAQLARMNKAVMNHHANAE----------REQKKEQERIEKERMRRLMAED 575

Human   824 EEFYVKYKNFSYLHCQWASIEDLEKDKRI-------------------QQKIKRFKAKQGQNKFL 869
            ||.|.|             :.|.:||||:                   |.|..:.|.|:.:.|.|
  Fly   576 EEGYRK-------------LIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRL 627

Human   870 SEIEDE-LFNPDYVEVD--------RIMDFARST------DDRGEPVTHYLVKWCSL-------- 911
            .:.:.| |.:.:|:.:|        |:....:.|      ||  .|:..:|.:|.::
  Fly   628 IQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDD--APMLKHLHRWLNMHPGWDWID 690

Human   912 PYEDSTWERRQDIDQAKIEEFEKLMSREPETERVERPPADD------WKKSESSREYKN------ 964
            ..|||...  .|..:.|:|  |:..:.|..|::.:....|:      .|......||:.
  Fly   691 DEEDSCGS--NDDHKPKVE--EQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYY 751

Human   965 ------------------NNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFL-YEI 1010
                              |..|:|||::|:.||:..:.|..|.|||||||||||||:|:.: |.:
  Fly   752 SIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLM 816

Human  1011 YLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGS 1074
            ..|.:.||:|:|.||||:|||..||..|. .:.||.|.||...||.:|        .|.|    :
  Fly   817 DRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ--------NQMR----A 869

Human  1075 YKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDL-EHKVLLTGTPLQ 1138
            .||:.::||:|.::.|...|..|.|:.::|||.||:||.:|||.:.|....: .:::||||||||
  Fly   870 TKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQ 934

Human  1139 NTVEELFSLLHFLEPSRFPSETTFMQEFG----------DLKTEEQ---VQKLQAILKPMMLRRL 1190
            |.:.||::||:||.||.|.|.:||.|.|.          :|..||.   :::|..:|:|.:||||
  Fly   935 NKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRL 999

Human  1191 KEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFL--------SKGGGQANVPNLLNTMME 1247
            |::||..|..|.|.||:.:::.:|:..|:.:..|.....        .|||.:|    |:||:::
  Fly  1000 KKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKA----LMNTIVQ 1060

Human  1248 LRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIF 1312
            |||.||||::....|||..:..........||     :.:.:||..|:|::||||||..||||:|
  Fly  1061 LRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPD-----LYRVSGKFELLDRILPKLKATNHRVLLF 1120

Human  1313 SQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTA 1377
            .||.:|:.|:||||..|::.|.|:||..:...|...:.:|:...||.|||||.|||||||:||..
  Fly  1121 CQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQT 1185

Human  1378 ADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSM 1442
            |||.:||||||||..|||||.|.|||||...|::.||:|.||.|..:...|..||.:|:.|:|:.
  Fly  1186 ADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAG 1250

Human  1443 SGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGS 1507
            ...:.:|...:|   :.::.:|.:..    .:||:|.....:|.|:.::.|....|.|.......
  Fly  1251 MFDQKSTGSERQ---QFLQTILHQDD----NEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAE 1308

Human  1508 TFAKASFVASGNRTDISLDDPNFWQKWAKK---------AELDIDALNGRNNLVIDTPRVRKQTR 1563
            ...:...:..|..   .|.|.:....|..|         .:.|.|.:.||.:      |.||:..
  Fly  1309 RKKEDEEIHPGRE---RLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGS------RQRKEVD 1364

Human  1564 LYSAVKEDELMEFSD--LESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILS 1626
            ...::.|.|.::..|  .|.|.||:        :|.|:...|....|.|::        ..|.|.
  Fly  1365 YTDSLTEKEWLKAIDDGAEFDEEEE--------EDDSKRKRRKRKNRKEES--------DDDSLI 1413

Human  1627 HGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPR 1691
            ..|.:||..::..:.....|:...:.|                 ..||:|        ||.|.
  Fly  1414 LKRRRRQNLDKRSKKQMHKIMSAVIKH-----------------NQDGRT--------LSEPF-- 1451

Human  1692 GRKGKKVKAQSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGNNATDQLYVLASCDLEQ 1756
                  :|..|.|.:           ||       |.:.:|.                 ..|:::
  Fly  1452 ------MKLPSRQRL-----------PD-------YYEIIKR-----------------PVDIKK 1475

Human  1757 VIQPLEDSLSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVPADWWDKEAD 1821
            ::|.:||      .:...|..|.::.:     ::.:.|          :.::.|....:.|..|.
  Fly  1476 ILQRIED------CKYADLNELEKDFM-----QLCQNA----------QIYNEEASLIYLDSIAL 1519

Human  1822 KSLLIGVFKHGYEKYNSMRADPALCFLERV-GMPDAKAIAAEQRGTDMLADGG---------DGG 1876
            :.:.:|.                   .:|: ...||.|:||.....:...:||         |||
  Fly  1520 QKVFVGA-------------------RQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGG 1565

Human  1877 EFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIH-------ATGKHSESNAELGQLYWP 1934
            :...:||                |.|.:.:...:..::::       ||...|.||...|.   .
  Fly  1566 DDGSDDE----------------EIATTSAAAVKMKLKLNKSLASAPATPTQSSSNVSSGA---A 1611

Human  1935 NTSTLTTRLRRLITAYQRSY 1954
            .||...||.:|    .|:.|
  Fly  1612 TTSKKQTRRKR----SQKKY 1627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830	103/412 (25%)
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	19/90 (21%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	16/78 (21%)
		PLN03142	967..>1566	CDD:215601	236/631 (37%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
brm	NP_001261906.1	QLQ	173..202	CDD:462622	8/28 (29%)
		Pro-rich	<247..401	CDD:464580	56/221 (25%)
		PTZ00121	<477..651	CDD:173412	41/221 (19%)
		HSA	501..573	CDD:214727	15/81 (19%)
		BRK	650..691	CDD:462196	7/42 (17%)
		PLN03142	739..>1368	CDD:215601	239/665 (36%)
		Bromo_SNF2L2	1425..1530	CDD:99947	26/212 (12%)