Protein Alignment CHD7 and Etl1

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_609320.2
• Gene: Etl1 / 34311
• FlyBaseID: FBgn0032157
• Length: 844
• Species: Drosophila melanogaster
• Alignment Length: 950
• Identity: 275/950 - (28%)
• Similarity: 428/950 - (45%)
• Gaps: 240/950 - (25%)

Human   631 RNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKK----------EPKEPKTPKAPKIP---KEPKE 682
            ::||...::.:..|..|.....|...:....||          :..:.:|||..|:.   ||.:|
  Fly    19 KSSLSDLRQFRINKNASSVVASPSRTERVPGKKRIQVMADSDSDGNDSQTPKKTKLELTVKEKEE 83

Human   683 KKAKTATPKP--------KSSKKSS------------NKKPDSEASALKKKVNKGKTEGSENSDL 727
            :....|...|        :|..:::            |.||......|.|...|.::.|....:.
  Fly    84 RYMAAAKISPHFDTMAIQESLSRTNWDVAASVRYLRENCKPKGHNGPLAKSKLKPRSNGISGGNF 148

Human   728 DKTPPPSPPPEEDEDPGVQKRRSSRQVKRKRYTEDLEFKISDEEADDADAAGRDSPSNTSQSEQQ 792
                       .|.|                :::|.:.|.|.::..|:|.:  ||..:|..:.|:
  Fly   149 -----------SDND----------------HSDDDDVKQSKDQVYDSDDS--DSEMSTKMTGQR 184

Human   793 ESVDAEGPVVEKIMSSRSVKKQKESGEEVEIEEFYVKYKNFSYLHCQWASIEDLEKDKRIQQKIK 857
            :.|                                     |.:::  .||:.:|:..|.:.:|
  Fly   185 KKV-------------------------------------FQFMN--EASLIELQSVKTLSEK-- 208

Human   858 RFKAKQGQNKFLSEIEDELFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQ 922
                     |.|:.|:...|: |:.::.:.::..|.:.|    :.:|..:..:          :|
  Fly   209 ---------KALAIIDVRPFS-DWSDLRQKLESIRMSGD----LLNYAQELIN----------KQ 249

Human   923 DIDQAKIEEFEKLMSREPETERVERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMR 987
            :...|.:.:...::|      |:|:..::.....|..:...:..:|.:||:.|:|||........
  Fly   250 NTVAAILSKCNNMVS------RLEKAISNGAGIVEQPKLLSSGLQLADYQIIGLNWLTVMHKQEM 308

Human   988 NCILADEMGLGKTIQSITFLYEIYLK--GI-HGPFLVIAPLSTIPNWEREFRTW-TELNVVVYHG 1048
            |.|||||||||||||.|.||  .|||  |: ....|::.|.||:.|||.|...| .||.|..|||
  Fly   309 NGILADEMGLGKTIQVIAFL--AYLKENGLSQAAHLIVVPSSTLDNWEAEISRWCPELVVEKYHG 371

Human  1049 SQASRRTIQLYEMYFKDPQGRVIKGSYK-FHAIITTFEMILTDCPELRNIPWRC----VVIDEAH 1108
            ||..||.:          :||..|..:. |..::||:. |:...||.|.:...|    |:.||||
  Fly   372 SQDERRRM----------RGRFAKDGFTGFDVLLTTYH-IVGSTPEERKMFRVCKLDYVIFDEAH 425

Human  1109 RLKNRNCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKT-- 1171
            .|||...:....|..::...::|||||||||.:.||.|||.|:.| :|     |.:...|:|:
  Fly   426 MLKNMTTQRYANLITINARMRILLTGTPLQNNLLELISLLCFVMP-KF-----FAKSIEDIKSLF 484

Human  1172 -----------------EEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETIIE-VELTNIQKKYY 1218
                             |.|:|:.:.|:||.:|||||:||.||| ||:.:::| |.:::.||.||
  Fly   485 AKKGKSDGDQDEVSQFQETQIQRAKRIMKPFVLRRLKKDVLKNL-PKKLSLVEKVPMSSQQKIYY 548

Human  1219 RAILEKNFTFLSKGGGQ-------ANVPNLLNTMMELRKCCNHPYL---------INGAEEKI-- 1265
            ..:::    :.|...|:       |.:.    .|||:|:..|||.|         :.|..:::
  Fly   549 HELVD----YYSNNKGEVCSSSERAGIA----IMMEMRRIANHPLLMRHYFTDANLRGFSKRLAN 605

Human  1266 LEEFKETHN-------AESPDFQLQAMIQA---------------AGKLVLIDKLLPKLKAGGHR 1308
            ...||:|:.       |...|||:..|:..               :||.:.:|.|||||||.|||
  Fly   606 ASSFKKTNEQYIFEELAVMSDFQVYQMMNKHEFYDVKIPDNLICDSGKFLYLDTLLPKLKAEGHR 670

Human  1309 VLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGI 1373
            ||:|||....|||:|:||..|::.:.|:||....|:||..|..|:..|| .|||||.|:|||:||
  Fly   671 VLLFSQFTMMLDIVEEYLRIRKFGFCRLDGATAVNVRQDLITDFNGDDS-IFVFLLSTKAGGVGI 734

Human  1374 NLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAV 1438
            ||||||||:|.|.|:||.||.||:.||||:||.:.|.|||||:.::.|..:...|..||.|:|.:
  Fly   735 NLTAADTCVIHDIDFNPYNDKQAEDRCHRMGQQRPVTIYRLISESTIEEGILMAAEEKLKLEKDI 799

Human  1439 LQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDE 1478
            ..:..|..:....|.:|...         |.|...|:|::
  Fly   800 TSNEKGEVHEQRCVVKLLTT---------ALGLDKDQEEQ 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	6/64 (9%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	6/56 (11%)
		PLN03142	967..>1566	CDD:215601	219/580 (38%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
Etl1	NP_609320.2	ComEA	<192..233	CDD:441164	10/54 (19%)
		HepA	<276..795	CDD:440319	211/547 (39%)