Protein Alignment CHD7 and Marcal1

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_608883.1
• Gene: Marcal1 / 33709
• FlyBaseID: FBgn0031655
• Length: 755
• Species: Drosophila melanogaster
• Alignment Length: 555
• Identity: 146/555 - (26%)
• Similarity: 228/555 - (41%)
• Gaps: 99/555 - (17%)

Human   947 RPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIY 1011
            :||....:...:|.|.|..::|..:|.:||   .|........::.||||||||.|::.  ...|
  Fly   226 QPPVVPERSVLASIEPKLADQLMPFQQDGV---CFAIAQKGRIMICDEMGLGKTYQALA--VADY 285

Human  1012 LKGIHGPFLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYFKDPQGRVIKGSYK 1076
            .|. ..|.||....||..:|.:.....  |..|..|..|..... |||            .|..|
  Fly   286 FKD-DWPLLVCTTASTRDSWAKHIMDL--LPKVPIHYVQVLNNN-QLY------------VGEAK 334

Human  1077 FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHK--VLLTGTPLQN 1139
              .:||::.|:.....:|....:..::.||:|.|||...|.....|.:..:.|  |||:|||..:
  Fly   335 --VLITSYNMMERHEDKLMQRKFGFIIFDESHTLKNSKAKCTTTAKRLTDQAKRVVLLSGTPALS 397

Human  1140 TVEELFSLLHFLEPSRFPSETTF--------MQEFG-DLKTEEQVQKLQAILK-PMMLRRLKEDV 1194
            ...|||:.|..:: .:|.:...|        ...|| |...:..:::|:.||. ..||||.|.:|
  Fly   398 RPLELFTQLQMID-GKFMNFMEFTTRYCDGKQSTFGWDANGQSNLEELKVILHLKYMLRRTKVEV 461

Human  1195 EKNLAPK-EETII---EVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHP 1255
            ...||.| .||::   .:..||.:.|.......|.   |....|:|
  Fly   462 LPQLAEKNRETVVLDPALVWTNAETKETLDAFNKE---LKTAKGRA------------------- 504

Human  1256 YLINGAEEKILEEFKETHNAESPDF--QLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRC 1318
                 .||.:|..:..|...::...  .|:.:::...|.::.         ..|||:
  Fly   505 -----TEEILLRFYARTAEVKTRAVCAYLKTLVKEQKKFIIF---------AHHRVM-------- 547

Human  1319 LDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCII 1383
            :|.:.|:|...:..|.||||:.|.:.|..::|.|.|..|.: |.||..:|...||.||||:..:.
  Fly   548 MDAISDFLSGLKVHYIRIDGQTRSDHRSDSVDTFQKKSSCK-VALLSLKACNSGITLTAAEIIVF 611

Human  1384 FDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFD------KASLKLGLDKAVLQSM 1442
            .:.||||....||::|.|||||:|.|....||..|:.:..:::      :...|:|:....||
  Fly   612 AELDWNPSTLAQAESRAHRIGQTKPVICRYLIAHNTADDIIWNMLKNKQEVLSKVGIFAENLQ-- 674

Human  1443 SGRENATNGVQQLSKKEIEDLLRKGAYGALMDEED 1477
                .||:.....|..:||:........:|..|.:
  Fly   675 ----KATHTAAPTSSHKIEEYFSPSTSTSLEPERN 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315
		CD2_tandem_CHD5-9_like	879..936	CDD:349310
		PLN03142	967..>1566	CDD:215601	141/535 (26%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
Marcal1	NP_608883.1	HARP	160..216	CDD:462166
		HepA	<233..666	CDD:440319	133/501 (27%)
		DEXHc_HARP_SMARCAL1	247..456	CDD:350768	64/232 (28%)