Protein Alignment CHD7 and okr

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_476661.1
• Gene: okr / 33507
• FlyBaseID: FBgn0002989
• Length: 784
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 168/575 - (29%)
• Similarity: 282/575 - (49%)
• Gaps: 88/575 - (15%)

Human   965 NNKLREYQLEGVNWLLFNWY--------NMRNCILADEMGLGKTIQSITFLYEIYLKGIH----- 1016
            :|.||.:|.|||.::    |        |...||:|||||||||:|.:|.::.:..:|..
  Fly   153 SNILRPHQREGVRFM----YECVEGKRGNFNGCIMADEMGLGKTLQCVTLVWTLLRQGPECKPTI 213

Human  1017 GPFLVIAPLSTIPNWEREFRTWTELNVVVYHG--------SQASRRTIQLYEMYFKDPQGR---- 1069
            ...:|::|.|.:.|||:||..|       .||        ......||:..|. |.....|
  Fly   214 NKAIVVSPSSLVKNWEKEFTKW-------LHGRLLCLPMEGGTKENTIRALEQ-FSMTSARLGTP 270

Human  1070 VIKGSYK----FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHKV 1130
            |:..||:    :..|:..:|:.:             |:.||.|||||.:....:.|..:..:.:|
  Fly   271 VLLISYETFRIYAEILCKYEVGM-------------VICDEGHRLKNSDNLTYQALMGLKTKRRV 322

Human  1131 LLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDL--------KTE-------EQVQKLQA 1180
            ||:|||:||.:.|.:||::|:.|....:...|.:.|...        .||       |:.|:|..
  Fly   323 LLSGTPIQNDLTEYYSLVNFVNPEMLGTAAVFKRNFESAILRGQNTDSTEQERQRAIEKTQELIG 387

Human  1181 ILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFT--FLSKGGGQANVPNLLN 1243
            ::...::||..:.:.|.|..|.|.:|..:||.||.:.|...|:.:..  .|:....:|::..|.:
  Fly   388 LVDQCIIRRTNQILTKYLPVKFEMVICAKLTAIQLELYTNFLKSDQVRRSLADCNEKASLTALAD 452

Human  1244 TMMELRKCCNHPYLINGAEEKIL---EEFKETHNAESPDFQLQAM-IQAAGKLVLIDKLLPKLKA 1304
             :..|:|.|:||.||   .||:.   :.|:.:.|....:::.:.: .:.:||.:|:|.:|..::|
  Fly   453 -ITTLKKICSHPDLI---YEKLTAREKGFENSQNVLPSNYKPKDLNPELSGKFMLLDFMLAAIRA 513

Human  1305 -GGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRA 1368
             |..:|::.|...:.||:.|....:|:|.:.|:||.:....|...:|||:.|:||.|:|:|.::|
  Fly   514 EGNDKVVLISNYTQTLDLFEQLARKRKYGFVRLDGTMSIKKRSKVVDRFNDPESDSFLFMLSSKA 578

Human  1369 GGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLG 1433
            ||.|:||..|:...:||.||||.||.||.||..|.||.|...||||:...|.|.::..:.:.|..
  Fly   579 GGCGLNLIGANRLFMFDPDWNPANDEQAMARVWRDGQKKPCYIYRLVASGSIEEKILQRQTHKKS 643

Human  1434 LDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDE-GSKFCEEDI 1487
            |...::      :|..:..:..::.:::||....| ..|.|..|: ..|.|.::|
  Fly   644 LSSTII------DNNESAEKHFTRDDLKDLFTFDA-NILSDTHDKLKCKRCVQNI 691

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315
		CD2_tandem_CHD5-9_like	879..936	CDD:349310
		PLN03142	967..>1566	CDD:215601	167/573 (29%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
okr	NP_476661.1	Rad54_N	<76..>126	CDD:430137
		HepA	<156..650	CDD:440319	157/528 (30%)
		DEXHc_RAD54A	156..396	CDD:350825	72/264 (27%)