Protein Alignment CHD7 and Chd1

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_001245851.1
• Gene: Chd1 / 33505
• FlyBaseID: FBgn0250786
• Length: 1900
• Species: Drosophila melanogaster
• Alignment Length: 1993
• Identity: 522/1993 - (26%)
• Similarity: 803/1993 - (40%)
• Gaps: 588/1993 - (29%)

Human   557 SPSEPFLEKPVPDMTQVSGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFP 621
            |.|:...|.| .|....|..||....|   ||..||..::..:.:......|.|.|.....|
  Fly   119 SDSDSDAEGP-SDQRNQSINNANTSSS---LPKPEQNEEEDNETEAGQQQPASDASADESSD--- 176

Human   622 GGVDNQELNRNSLDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAK 686
               .:..::..|...|.||:::..|.|..:..::|....||.:       |||    .||.|| |
  Fly   177 ---SSANVSPTSSSSSSEEEEEDYRPKRTRQARKPPTAAEKSK-------KAP----APKNKK-K 226

Human   687 TATPKPKSSKKSSNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEED-EDPGVQKRRS 750
            |.    .|.:...::..|.|.|..:|:.....|..|:.:...:.....|...|| :|....||.:
  Fly   227 TW----DSDESDESEDSDDEVSTAQKRKPAATTSRSKLAQQQQRRRVKPFSSEDSDDDDASKRCA 287

Human   751 SRQ----VKRKRYTED--------LEFKISDEEADDADAAGRDSPSNTSQSEQQESVDAEGPVVE 803
            :|:    |..|..:||        |||     |.|::.||     :..:.:|::|..:    .:|
  Fly   288 TRRKGAAVSYKEASEDEATDSEDLLEF-----EYDESQAA-----TTAATAEEEEKCE----TIE 338

Human   804 KIMSSRSVKK------------------------QKESGEEVEIEEFYVKYKNFSYLHCQW---A 841
            :|::.|:.|:                        :|::.:.....:|.:|:|.:||:|..|   |
  Fly   339 RILAQRAGKRGCTGNQTTIYAIEENGFDPHAGFDEKQTPDAETEAQFLIKWKGWSYIHNTWESEA 403

Human   842 SIEDLEKD--KRIQQKIKRFKAKQGQNKFLS-----------EIEDELFNPDYVEVDRIMDFARS 893
            ::.|::..  |::...||:.|.:....::..           |::.||.. .|..||||:.....
  Fly   404 TLRDMKAKGMKKLDNFIKKEKEQAYWRRYAGPEDIDYFECQLELQHELLK-SYNNVDRIIAKGSK 467

Human   894 TDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKI--------EEFE-------------KLMS 937
            .||..|   .||.||.||||.:||||     |.|.:        |:|.             :::.
  Fly   468 PDDGTE---EYLCKWQSLPYAESTWE-----DAALVLRKWQRCAEQFNDRESSKCTPSRHCRVIK 524

Human   938 REPETERVERPPADDWKKSESSREYKNNN-KLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTI 1001
            ..|:..|::..|           |:.::. .||:||::|:||||.:|....:.||||||||||||
  Fly   525 YRPKFSRIKNQP-----------EFLSSGLTLRDYQMDGLNWLLHSWCKENSVILADEMGLGKTI 578

Human  1002 QSITFLYEIY-LKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQLYEMYFK 1064
            |:|.|||.:: :..::||||.:.||||:..|:|||..|. ::|||.|.|...||..||.||..|:
  Fly   579 QTICFLYSLFKIHHLYGPFLCVVPLSTMTAWQREFDLWAPDMNVVTYLGDIKSRELIQQYEWQFE 643

Human  1065 DPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLKMMDLEHK 1129
            ..:      ..||:.|:||:|::|.|...|..:.|..:::||||||||.:..|.:.||..|..|:
  Fly   644 SSK------RLKFNCILTTYEIVLKDKQFLGTLQWAALLVDEAHRLKNDDSLLYKSLKEFDTNHR 702

Human  1130 VLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDV 1194
            :|:|||||||:::||::||||:.|.:|.:...|..:.|:.: ::...:|...|:|.:|||:|:||
  Fly   703 LLITGTPLQNSLKELWALLHFIMPDKFDTWENFEVQHGNAE-DKGYTRLHQQLEPYILRRVKKDV 766

Human  1195 EKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLIN 1259
            ||:|..|.|.|:.||:|::||:||:.||.|||..|.| |.:.:....||.::||:|||||..||.
  Fly   767 EKSLPAKVEQILRVEMTSLQKQYYKWILTKNFDALRK-GKRGSTSTFLNIVIELKKCCNHAALIR 830

Human  1260 GAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILED 1324
            .:|.:::        ....|..||.:::.:|||||:||||.:||..||||||||||||.||:|.|
  Fly   831 PSEFELM--------GLQQDEALQTLLKGSGKLVLLDKLLCRLKETGHRVLIFSQMVRMLDVLAD 887

Human  1325 YLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWN 1389
            ||.:|.:|::|:||.::|.:|:.|:|.|:...|..|.|||.||||||||||..|||.||||||||
  Fly   888 YLQKRHFPFQRLDGSIKGEMRRQALDHFNAEGSQDFCFLLSTRAGGLGINLATADTVIIFDSDWN 952

Human  1390 PQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSM----------SG 1444
            ||||||||||.|||||...|.||||:|..|.|.::.::|..|:.||..|:|.|          ||
  Fly   953 PQNDLQAQARAHRIGQKNQVNIYRLVTARSVEEQIVERAKQKMVLDHLVIQRMDTTGRTVLDKSG 1017

Human  1445 RENATNGVQQLSKKEIEDLLRKGAYGALMDE-EDEGSKFCEEDIDQILLRRTHTITIESEGKGST 1508
            ..:::|. ...:|.::..:|:.||.....|| |.:....|  |||:| |||..|..
  Fly  1018 NGHSSNS-NPFNKDDLSAILKFGAEELFKDEQEHDDDLVC--DIDEI-LRRAETRN--------- 1069

Human  1509 FAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSAVKEDEL 1573
                             :||          |:..|                   .|.||.|...:
  Fly  1070 -----------------EDP----------EMPAD-------------------DLLSAFKVASI 1088

Human  1574 MEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQD 1638
            ..|.:..|||..|........:|.|:.                    |.||:..| :::.:.:|
  Fly  1089 AAFEEEPSDSVSKQDQNAAGEEDDSKD--------------------WDDIIPEG-FRKAIDDQ- 1131

Human  1639 VETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRKGKKVKAQST 1703
                               |..|. :.||..|.   :.:...|.:.......:|.|||    |..
  Fly  1132 -------------------ERAKE-MEDLYLPP---RRKTAANQNEGKRGAGKGGKGK----QQA 1169

Human  1704 QPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGNNATD------------------QLYVLA 1750
            .....|:|:  ....|....:...:|..:..........||                  ::..:|
  Fly  1170 DDSGGDSDY--ELGSDGSGDDGRPRKRGRPTMKEKITGFTDAELRRFIRSYKKFPAPLHRMEAIA 1232

Human  1751 SCDLEQVIQPLEDSLSWVLLR---------VRMLYYLRQEVIGDQADKILEGADSSEADVWIP-- 1804
             ||.|...:||.:     |.|         |:.|:..::|.....|.....||....|.....
  Fly  1233 -CDAELQEKPLAE-----LKRLGEMLHDRCVQFLHEHKEEESKTAATDETPGAKQRRARATFSVK 1291

Human  1805 ------------------EPFHAEVPA------DW--------------WDKEADKSLLIGVFKH 1831
                              :|.:..:|:      .|              |..|.|..||.|::::
  Fly  1292 LGGVSFNAKKLLACEQELQPLNEIMPSMPEERQQWSFNIKTRAPVFDVDWGIEEDTKLLCGIYQY 1356

Human  1832 GYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDM------------LADGG----------- 1873
            |...:..|:.||.|...:::.:.|.:...|:|..|..            |..||
  Fly  1357 GIGSWEQMKLDPTLKLTDKILLNDTRKPQAKQLQTRAEYLLKIIKKNVELTKGGQRRQRRPRASR 1421

Human  1874 ---------------DGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGKHSE 1923
                           |....|.||...:.:........::|....||.       ...||.:|.:
  Fly  1422 ANDAKAASQSASSTIDAKPHDGEDAAGDARTVAESSNSQVDPSTASPH-------NAPATEQHGD 1479

Human  1924 SNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRP-----REEVRALEA 1983
            .                          .:..|:.:.|.:....:|....:|     ..|.||||.
  Fly  1480 P--------------------------AKKAKKSKARSKKTSASDNNGNKPMHFTANNEPRALEV 1518

Human  1984 ERE---AIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYF 2045
            ..:   :|.:|.::|                   ..|||        :|...||:
  Fly  1519 LGDLDPSIFNECKEK-------------------MRPVK--------KALKALDQ---------- 1546

Human  2046 SCFVAMCRRVCRMPVKPDDEPPDLSSIIEPITEERASRTLYRIELLRKIREQVLHHPQLGERLKL 2110
                                 ||:|     ::::         :.|:..|:.:|   |:|:::.:
  Fly  1547 ---------------------PDVS-----LSDQ---------DQLQHTRDCLL---QIGKQIDV 1573

Human  2111 C---QPSLDLPEW----WECGRHDRDLLVGAAKHGVSRTDYHILNDPELSFLDAHKNF-----AQ 2163
            |   ....:..||    |                      |.:....|   |||.:.|     |.
  Fly  1574 CLNPYAETEKKEWRSNLW----------------------YFVSKFTE---LDAKRLFKIYKHAL 1613

Human  2164 NRGAGNTSSLNPLAVGFVQTPPVISSAHIQDERVLEQAEGKVEEPENPAAKEKCEG---KEEEEE 2225
            .:.||...                            :|:||.:......||.|..|   :|:|:|
  Fly  1614 KQKAGGDG----------------------------EAKGKDKGSSGSPAKSKPNGVTTEEKEKE 1650

Human  2226 TDGS-GKESKQECEAEASSVKNELKGVEVGADTGSKSISEKGSEEDEEEKLEDDDKSEESSQPEA 2289
            .|.| ||:.|::.:.|.|   .:.:..|.|..|       .|...|...|.:.|:...::|...|
  Fly  1651 RDRSGGKKKKKDKDKERS---GQARYPETGIPT-------SGRYADPPLKRKRDENDADASSGLA 1705

Human  2290 GAVSR--GKNFDEESNASMSTARDETR------DGFYMEDGDP 2324
            ||...  |.|....|...::..|.|.|      ..:|...|.|
  Fly  1706 GAPGGGIGDNLKSMSFKRLNMDRHEDRKKHHRGPDYYGGSGPP 1748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830	6/20 (30%)
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	17/93 (18%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	24/77 (31%)
		PLN03142	967..>1566	CDD:215601	257/611 (42%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
Chd1	NP_001245851.1	CD1_tandem_CHD1-2_like	339..421	CDD:349313	14/81 (17%)
		CD2_tandem	454..508	CDD:349306	24/61 (39%)
		PLN03142	531..>1066	CDD:215601	254/565 (45%)
		CDH1_2_SANT_HL1	1205..1298	CDD:465731	17/98 (17%)
		DUF4208	1521..1610	CDD:464035	27/188 (14%)