DRSC/TRiP Functional Genomics Resources

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Protein Alignment CHD7 and hrp1

DIOPT Version :10

Sequence 1:XP_011515855.1 Gene:CHD7 / 55636 HGNCID:20626 Length:3027 Species:Homo sapiens
Sequence 2:NP_593660.1 Gene:hrp1 / 2542363 PomBaseID:SPAC1783.05 Length:1373 Species:Schizosaccharomyces pombe


Alignment Length:1650 Identity:447/1650 - (27%)
Similarity:716/1650 - (43%) Gaps:390/1650 - (23%)


- Green bases have known domain annotations that are detailed below.


Human   529 PPHPHHQPWAQLHPS--------------PQ--NTPQKVPV------HQHS-PSEPFLEKPVPDM 570
            |.|.::.  .:.||:              ||  ||...:|.      |::| .|:..|.....|.
pombe     3 PEHSNYD--LKNHPTSVQESTLNGSAVTDPQFGNTTNSLPSMNGLLNHENSFASQQSLSSSAFDD 65

Human   571 TQV--SGPNAQLVKSDDYLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFPGGVDNQELNRNS 633
            :::  |..|:.:|.|....|.|:                                 |.|..:...
pombe    66 SEIVTSTANSTVVSSALSTPKID---------------------------------DAQNSDDVR 97

Human   634 LDGSQEEKKKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIPKEPKEKKAKTATPKPKSSKKS 698
            :||:      ::.|:||:.........|..|.:.|       |||:.|.|      |.||..|..
pombe    98 VDGT------RRSSRAKRPVYRDFSYTEIDEHEIP-------IPKKRKSK------PAPKQKKSV 143

Human   699 SNKKPDSEASALKKKVNKGKTEGSENSDLDKTPPPSPPPEEDEDPGVQKRRSSRQVKRK--RYTE 761
            ::...|:.....:..:|...                         |.:.|.|.|..|.|  .|.|
pombe   144 ASDDEDAYDKRHRFSINSAS-------------------------GTEIRTSLRSSKGKSVNYNE 183

Human   762 DLEF--KISDEEADDADAAGRDSPSNTSQSEQQESVDAE-GPVVEKIMSSRSVKKQKESGEEVEI 823
            . ||  ...|||                 .|.:|.|:.| .|:::.:::.|. :...:..:....
pombe   184 Q-EFYDDFEDEE-----------------EEVEEQVEEEYEPIIDFVLNHRK-RADAQDDDPKSS 229

Human   824 EEFYVKYKNFSYLHCQW---ASIEDLEKDKRIQQKIKR-----FKAKQGQNKFLSEIE------- 873
            .::.:|::..|:||..|   :::..:...|::...||:     .:.::.......:||       
pombe   230 YQYLIKWQEVSHLHNTWEDYSTLSSVRGYKKVDNYIKQNIIYDREIREDPTTTFEDIEALDIERE 294

Human   874 --DELFNPDYVEVDRIMDFARSTDDRGEPVTHYLVKWCSLPYEDSTWERRQDIDQAKIEEFEKLM 936
              :.||. :|..|:||:  |..|::.|:  |.|.|||..|||::.|||....|......|..:.:
pombe   295 RKNMLFE-EYKIVERIV--ASETNEEGK--TEYFVKWRQLPYDNCTWEDADVIYSMAPNEVYQFL 354

Human   937 SREPETERV-------ERPPADDWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADE 994
            .||......       .|||   ::|.|....|....::|::||.|:||:.:.|:...|.|||||
pombe   355 QRENSPYLPYKGVFYNTRPP---YRKLEKQPSYIKGGEIRDFQLTGINWMAYLWHRNENGILADE 416

Human   995 MGLGKTIQSITFL-YEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRRTIQ 1057
            ||||||:|::.|| |.::....|||||::.||||:|.|:.....|| :||.:.|.|:..||..|:
pombe   417 MGLGKTVQTVCFLSYLVHSLKQHGPFLIVVPLSTVPAWQETLANWTPDLNSICYTGNTESRANIR 481

Human  1058 LYEMYFKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLLEGLK 1122
            .||.|......::     ||:.::||:|.||.|..||.||.|:.:.|||||||||....|.|.|.
pombe   482 EYEFYLSTNSRKL-----KFNILLTTYEYILKDKQELNNIRWQYLAIDEAHRLKNSESSLYETLS 541

Human  1123 MMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRF--PSETTFMQEFGDLKTEEQVQKLQAILKPM 1185
            .....:::|:|||||||.::||.||::||.|.:|  ..|..|.|.  :.:.|..::.||..|:|.
pombe   542 QFRTANRLLITGTPLQNNLKELASLVNFLMPGKFYIRDELNFDQP--NAEQERDIRDLQERLQPF 604

Human  1186 MLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFL---SKGGGQANVPNLLNTMME 1247
            :|||||:||||:|..|.|.|:.|||:::|.::|:.||.||:..|   :.|.||.   :|||.::|
pombe   605 ILRRLKKDVEKSLPSKSERILRVELSDMQTEWYKNILTKNYRALTGHTDGRGQL---SLLNIVVE 666

Human  1248 LRKCCNHPYLINGAEEKILEEFKETHNAESPDFQLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIF 1312
            |:|..|||||..||.||.:...|.|.     :..|:.:|..:||:||:||||.:||..|||||||
pombe   667 LKKVSNHPYLFPGAAEKWMMGRKMTR-----EDTLRGIIMNSGKMVLLDKLLQRLKHDGHRVLIF 726

Human  1313 SQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTA 1377
            |||||.|:||.:|:..|.|.|:|:||.:..::|:.:||.|:.|||..|||||.||||||||||..
pombe   727 SQMVRMLNILGEYMSLRGYNYQRLDGTIPASVRRVSIDHFNAPDSPDFVFLLSTRAGGLGINLNT 791

Human  1378 ADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSM 1442
            |||.||||||||||.||||.||.|||||...|.:||.:::::.|.::.::|..|:.|:.|:: |:
pombe   792 ADTVIIFDSDWNPQADLQAMARAHRIGQKNHVNVYRFLSKDTVEEDILERARRKMILEYAII-SL 855

Human  1443 SGRENATNGV-QQLSKKEIEDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGK- 1505
            ...|.:.|.. .:...:|:..:|:.||.......|:: .|....::|.||   :|....:|... 
pombe   856 GVTEKSKNSKNDKYDAQELSAILKFGASNMFKATENQ-KKLENMNLDDIL---SHAEDRDSSNDV 916

Human  1506 -GSTFAKASFVASGNRTDISLDDPNFWQKWAKKAELDIDALNGRNNLVIDTPRVRKQTRLYSA-- 1567
             |::.....|:.....||...:|.| |.....:.|::               |:.::.|:.:|  
pombe   917 GGASMGGEEFLKQFEVTDYKAEDLN-WDDIIPEEEME---------------RIEEEERMLAAQR 965

Human  1568 VKEDELMEFSDLESDSEEKPCAKPRRPQDKSQGYARSECFRVEKNLLVYGWGRWTDILSHGRYKR 1632
            .||:|.....:.|.:::|         ...|:.|.|:                 |..::..:.:|
pombe   966 AKEEERERREEEERENDE---------DHPSRTYKRT-----------------TKSITKRQQRR 1004

Human  1633 Q--LTEQDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRKG 1695
            :  :.|:::..:.|.::.:.|                    .|.:...:|..:.|.|..|     
pombe  1005 EEMVREKEIRLLYRAMIKFGL--------------------VDERFDTIVKEAELQATDP----- 1044

Human  1696 KKVKAQSTQPVVQDADWLASCNP--DALFQEDSYKKHLKHHCNNSGNNATDQLYVLASCDLEQVI 1758
            |::.:.|       ||.:.:|:.  :.|..:|:..|                             
pombe  1045 KRIYSLS-------ADMVKACDEAVERLGADDTKNK----------------------------- 1073

Human  1759 QPLEDSL-----------SWVLLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPEPFHAEVP 1812
            ||.:..|           ..|.|||:.|.:|.:...|....|.:.|........|         .
pombe  1074 QPRKAILIEFKGVKNINAETVTLRVKDLTHLHRAYKGLDPLKQIIGYPIRSVHSW---------N 1129

Human  1813 ADWWDKEADKSLLIGVFKHGYEKYNSMRADPALCFLERVGMPDAK----------AIAAEQRGTD 1867
            ..|..|| |..||.|:.|||:..:.:::.||.|...:::.:.:||          |:...:||..
pombe  1130 CSWGIKE-DSMLLAGINKHGFGCWQAIKNDPDLGLHDKIFLDEAKNDKESRYVPSAVHLVRRGEY 1193

Human  1868 MLADGGDGGEFDREDEDPEYKPTRTPFKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLY 1932
            :|:       ..||..|.....|..|.|.:.:..|.:.|..::.:::              |.:.
pombe  1194 LLS-------VVREHPDLFVVKTDQPTKRKYNRKAPTKSSTRQTTLD--------------GSIS 1237

Human  1933 WPNTSTLTTRLRRLITAYQRSYKRQQMRQEALMKTDRRRRRPRE---EVRALEAEREAIISEKRQ 1994
            ....|:.|.:.:.     :.:.:..:...|..:..|.....||:   ..|||.:......|.|| 
pombe  1238 NTKKSSRTKKKKE-----EETNRGDETSPEGTVGEDEVEEEPRQAEPPKRALRSNSGKAASNKR- 1296

Human  1995 KWTRREEADFYRVVSTFGVIFDPVKQQFDWNQFRAFARLDKKSDESLEKYFSCFVAMCRRVCRMP 2059
              |.|.....:..:.|...:     ...|       |.||..|:|..::...            .
pombe  1297 --TTRNSMKTHSAMDTLTAV-----AALD-------AELDNMSNEKAKEEVD------------H 1335

Human  2060 VKPDDEPPDLSSIIEPITEERASRT 2084
            ||.::.    .|:.||.||:.:..|
pombe  1336 VKSENG----ESVNEPNTEDLSLET 1356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CHD7XP_011515855.1 Atrophin-1 197..>578 CDD:460830 15/73 (21%)
CD1_tandem_CHD5-9_like 796..861 CDD:349315 11/73 (15%)
CD2_tandem_CHD5-9_like 879..936 CDD:349310 20/56 (36%)
PLN03142 967..>1566 CDD:215601 250/608 (41%)
BRK 2593..2634 CDD:462196
BRK 2672..2716 CDD:197800
hrp1NP_593660.1 CD1_tandem_CHD1_yeast_like 207..266 CDD:349312 8/59 (14%)
CD2_tandem 302..355 CDD:349306 20/56 (36%)
PLN03142 377..>909 CDD:215601 242/551 (44%)
Cdh1_DBD_1 1010..1090 CDD:408024 19/140 (14%)
CHDCT2 1132..>1159 CDD:462358 10/27 (37%)
Blue background indicates that the domain is not in the aligned region.

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