Protein Alignment CHD7 and mit1

DIOPT Version :10

• Sequence 1: XP_011515855.1
• Gene: CHD7 / 55636
• HGNCID: 20626
• Length: 3027
• Species: Homo sapiens
• Sequence 2: NP_595385.1
• Gene: mit1 / 2541336
• PomBaseID: SPBP35G2.10
• Length: 1418
• Species: Schizosaccharomyces pombe
• Alignment Length: 1075
• Identity: 307/1075 - (28%)
• Similarity: 479/1075 - (44%)
• Gaps: 207/1075 - (19%)

Human   825 EFYVKYKNFSYLHCQWASIE-----DLEKDKRIQQKIKRFKAKQGQNKFLSEIEDELFNPDYVEV 884
            |::|:.|..|||||.|.|..     .|.|.|..          .|......:....:....|..:
pombe   394 EYFVRSKGKSYLHCFWCSASWLAGISLAKKKNF----------DGLENASYDATKPIIPVSYTII 448

Human   885 DRIMDF-------ARSTDDRGE--------PVTHYLVKWCSLPYEDSTWE-RRQDIDQAKIEEFE 933
            |::.|.       ||:...:.:        .||...|.|..|.|..|.|| ..::.|:.:.:.:.
pombe   449 DKVWDVQYRSGKNARTAKYKTKKHQLKAISEVTFAFVSWRGLTYYMSNWEPPPKETDRNRWKAWL 513

Human   934 KLMSREPETERVERPPAD-----------DWKKSESSREYKNNNKLREYQLEGVNWLLFNWYNMR 987
            |..|...|...:|:.|..           :|   .|...:.....|..|||:|:|||...||...
pombe   514 KGYSDLLECLWIEKAPTASINIDLPFTNLEW---HSQPSFIKGGTLMPYQLKGLNWLYLRWYTHH 575

Human   988 NCILADEMGLGKTIQSITFLYEIYLKGIHGPFLVIAPLSTIPNWEREFRTWT---ELNVVVYHGS 1049
            .||||||||||||:|.|:|:..::.:....|.|||.|.:|:.|||||.:.|.   ::||:|  ||
pombe   576 PCILADEMGLGKTVQVISFISVLFYRHKCFPVLVIVPHATVANWERELKKWAPFLQINVLV--GS 638

Human  1050 QASRRTIQLYEMY-FKDPQGRVIKGSYKFHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNR 1113
            :.:|..::.|.:. .|||:      ....|.::.:...:..:...||...|:.:::||..||||.
pombe   639 EKNRSLVRDYRLINQKDPK------HVSTHVLVISASNVEREISLLRKFQWKVLIVDEGQRLKND 697

Human  1114 NCKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKL 1178
            ...|...|..:..:.|:|||||||||.|.|||:||.||.|.:. :.....:.:..:.| |:|.:|
pombe   698 QSSLFYYLSSVKSDFKLLLTGTPLQNNVRELFNLLQFLNPMKI-NAAELEKRYSIIDT-EKVTEL 760

Human  1179 QAILKPMMLRRLKEDVEKNLAPKEETIIEVELTNIQKKYYRAILEKNFTFL---------SKGGG 1234
            ..||||..|||:|.:|..|...|.|.||.:.:|.:||..|::||.||.:.|         |..||
pombe   761 HQILKPFFLRRVKSEVLDNFPTKVEVIIPLSMTPVQKGLYKSILSKNLSLLRNITGYANTSSSGG 825

Human  1235 QANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFKETHNAESPDFQ---------LQAMIQAAG 1290
            | ...:|.|.:|:|||...|||:.                  |||.:         ::::.:|:.
pombe   826 Q-RTTSLNNILMQLRKTLAHPYIY------------------SPDIEDRNLPYELAMRSLEEASC 871

Human  1291 KLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSKP 1355
            |.:::..|:|||...|||:|:|||.::.||||||:...:...|.|.||......||:|||.|:.|
pombe   872 KFLILRLLVPKLITRGHRILLFSQFIQQLDILEDWFEYKNIAYARFDGASSEMERQSAIDSFNAP 936

Human  1356 DSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSY 1420
            :|:...|||.|||||:||||.:|||.||.|.|:||..|:||.||.||.||.|.|.::.|.||:|.
pombe   937 NSELSCFLLSTRAGGVGINLASADTVIILDPDFNPHQDMQAIARAHRYGQKKKVLVFVLTTRDSV 1001

Human  1421 EREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEIEDLLRKGAYGALMDEEDEGS-KFCE 1484
            |.::...|..||.||..:::|:....|        |:|::|.:||.||.....:..||.| |:.|
pombe  1002 EEKIIQNAQKKLVLDHLIVESLDQNHN--------SEKDLESILRHGARALFEEAGDEPSIKYNE 1058

Human  1485 EDIDQILL---RRTHTITIESEGKGSTFA-----KASFVASGN---RTDISLDDPNFWQKWAKKA 1538
            ..::.::.   ::..|.|.||:.|.:.|.     ....::|.:   :.::.:|:.:.|....|:.
pombe  1059 YSVELLISEAEKQEDTSTDESDIKSNKFGFFRVWDNKHISSNHYEVKENVLVDEEDVWSVILKQR 1123

Human  1539 ELDIDALNGRNNLVIDTPRVRKQTRLYSAVKED-ELMEFSDLESDSEEKPCAKPRRPQDKSQGYA 1602
            |.  ||:..:.:......|:|...:::..  || .:.:.|| ::|......:.|..|
pombe  1124 EK--DAMLEKTDETTSNRRLRAHHKIHYG--EDLNIYDNSD-DTDYTVNDRSSPGSP-------- 1175

Human  1603 RSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTEQDVETICRTILVYCLNHYKGDENIKSFIWDL 1667
                |.:|...:    ...||.||..:..:..:..::|.         ||.....:......:|.
pombe  1176 ----FPIETETI----SSITDTLSDKQKLKYDSSVNIEN---------LNDESDSQKSADVHFDS 1223

Human  1668 I--------TPTADGQTRAL----------------VNHSGLS--------APVPRGRKGKKVKA 1700
            |        ||..|...:.|                :|.|.:.        .|.....|..::..
pombe  1224 ILAKSLLATTPKEDEFNKTLSTINLEVANKLTSSEYINDSEMQLIDDPVFYPPYEIIEKNHQLVG 1288

Human  1701 QSTQPVVQDADWLASCNPDALFQEDSYKKHLKHHCNNSGNNATDQLYVLASCDL----------- 1754
            :|....|.|..:|.|...|.:.......|||..||..|       :..|..|.|
pombe  1289 RSLSKAVLDNFFLLSSLSDNVRCRCCGIKHLPAHCPLS-------IVPLEICFLCGTPHFSGRDT 1346

Human  1755 ------EQVIQPLEDSLSWVLLRVRMLYYLRQEVI 1783
                  ::.|..|:||||    :.|..::::::.:
pombe  1347 CPMLRNKEAIYRLKDSLS----KSREPFHIKKQAM 1377

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CHD7	XP_011515855.1	Atrophin-1	197..>578	CDD:460830
		CD1_tandem_CHD5-9_like	796..861	CDD:349315	13/40 (33%)
		CD2_tandem_CHD5-9_like	879..936	CDD:349310	16/72 (22%)
		PLN03142	967..>1566	CDD:215601	223/632 (35%)
		BRK	2593..2634	CDD:462196
		BRK	2672..2716	CDD:197800
mit1	NP_595385.1	PHD	214..268	CDD:214584
		CD_CSD	359..426	CDD:475127	13/31 (42%)
		PLN03142	546..>1086	CDD:215601	214/576 (37%)
		zf-CCCH_7	1235..1329	CDD:376012	18/100 (18%)
		zf-CCCH_6	1331..1383	CDD:436598	9/51 (18%)