|
Human 1 MADPGMMSLFGEDGNIFSEGLEGLGECGYPENPVNPMGQQMPIDQGFASLQPSLHHPSTNQNQTK 65
|||..||. |.......:..:|:.: .||..|:||..||.. ||......|
Worm 14 MADYTMMG--GPPPQQSQQSQQGVPQ-RYPGQPMNPYEQQQQ------------HHQMMMMQQ-- 61
Human 66 LTHFDHYNQYEQQKMHLMDQPNRM----------------------------------------- 89
:.|..|:...|.::
Worm 62 ----------QHQMQHMAPPPQQVPPQPAQPPPAKKARGKSKKAQAEAAAAAAAAAAAQMDPMAS 116
Human 90 ---MSNTP---GNGLASPHSQYHTPPVPQVPHGGSGGGQMGVYPGMQNE---RHGQSFVDSSSMW 145
|||.| ..|..:..:.|...|.|..| ..:|..|.|..||.... ..||.
Worm 117 MAAMSNNPMMRQGGYPNQMAMYGGVPPPHYP-SSNGPSQQGYRPGPVTNGPPPQGQY-------- 172
Human 146 GPRAVQVPDQIRAPYQQQQPQPQ--------------------------PPQP------AP-SGP 177
|...|.|...:..|.||:.|.| ||.| || :||
Worm 173 -PPPPQAPQNYQQMYHQQRAQQQQAGQQQAQGPPGYGPYGYAPQASTGYPPPPSQQSPYAPQAGP 236
Human 178 PAQ---GHPQHMQQMG------SYMARG-----DFSMQQHGQP-----QQRMSQFSQ-GQEGLNQ 222
|.| .:|.|.||.. .|...| ....||.|.| ..:|:|..| |:.|.|.
Worm 237 PPQMRHQYPPHSQQQAPPGYWDGYQGYGGPPPSQQQQQQGGGPVTAPQSMQMAQQEQWGRVGTND 301
Human 223 GNPFIA---TSGPGHLSHVPQ--------QSPSMAPSLRHSVQQF---HHHPSTALH-------- 265
....|| .|.....:.:.| .:.:....|:|.:.|| |:..|..|.
Worm 302 LMNVIAQVEKSSAECKARIQQLYNMQRSASADAEVQQLQHKLAQFQSDHYRYSQQLQHVQWQQQQ 366
Human 266 ------GESVAHSPRFSPNPPQQGAVRPQTLNFSSRSQTVPS-----PT-INNSGQ--------- 309
..:.|.:...|.....||...|. ||:|..:|| |. :|..|.
Worm 367 QQQQAAAAAAAAAAAASAGGHHQGPPPPT----SSQSNQIPSNPNSVPVHVNQPGSQVHITADKT 427
Human 310 ---YSRY--PYSNLNQGLVNNTGMNQNLGLTNNTPMNQSVPRYPNAV-----------------G 352
.|.| .|.....| .::|...:::.....||..|..| .|||. |
Worm 428 RTLISVYHDGYGGAGSG-ASSTESKESIVPPEPTPSMQESP-VPNAPQVKMEPEKPSPYQQQYNG 490
Human 353 FPSNSGQGLMHQQPIHPSGSLNQMNTQTMHPSQPQGTYASPPPMSPMKAMSNPAGTPPPQVRPGS 417
..:.||.....||..||..:..|.. |..|....| |.:|.|..|.:|..
Worm 491 MENGSGNPYAQQQQQHPMYAQYQQQ-QQQHAQHQQ----------------NMSGYPQQQQQPQH 538
Human 418 AGIPMEVGSYPNMPHPQPSHQPPGAMGIGQRNMGPRNMQQSRPF---IGMSSAPRELTGHMRPNG 479
.....:..|.|...||| |.| .|....|...||..|. ||:|:|| ..|.|:
Worm 539 PHQHQQPASVPMQHHPQ---QHP-----SQHQTQPNQQQQQHPSGYGIGVSTAP----ASMEPS- 590
Human 480 CPGVGLGDPQAIQERLIPGQ-------------QHPGQQPSFQQLPT---------CPPLQPHPG 522
|::.:...|.| |.....|.|...|: .|...|.|.
Worm 591 ---------QSVDQSAPPSQAQIPATSTPSTSSQQQNAYPEFPDFPSSSGYQEPTVAPEAIPSPS 646
Human 523 LHHQSSPPHPHHQPWAQLHPSPQNTPQKVPVHQHSPSEPFLEKPVP--DMTQVSGPNAQLVKSDD 585
:.....|....:....|.....|...:.|| ..||.:|:..| :.:|.:.|
Worm 647 VSDPIMPQSSQNDQELQAISDQQEILEDVP-----KEEPIIEEDEPKYEYSQETIP--------- 697
Human 586 YLPSIEQQPQQKKKKKKNNHIVAEDPSKGFGKDDFPGGVDNQE------LNRNSLDGSQE---EK 641
:..::.:.:.|:.::..::::.:|. |.|:| |.|:| .|...||..:: |.
Worm 698 -VEELKDEVEFKEDQQSTSNLLEDDT----GIDNF---VKNEEGAEAGYSNGTPLDQVEQNDYEN 754
Human 642 KKKKRSKAKKDPKEPKEPKEKKEPKEPKTPKAPKIP--KEPKEKKAKTATPKPKSSKKSS----- 699
.:|:..:...|| ||.|.:.::||.:.:....|.:. :||.|:.|:....:|:....||
Worm 755 IEKEEPQVSVDP-EPVEVEAQQEPADTEEYPIPSVGTIEEPAEEPAEEPVEEPEPMDDSSPVDQS 818
Human 700 ------------------------NKKPDSEASALKKKVNKGKTEGSENS-----DLDKTP---- 731
..:.|.|||:.|...:..|.|..::: |:.:.|
Worm 819 TPVKADDIENFAGVEETFGEEEEVQDEDDDEASSAKSSKDDIKEEEDDDTSTITKDMSEAPSETN 883
Human 732 ----PPSPPPEEDEDPGVQKRRSSR-------QVKRKRYTEDLEFKISDEE-------------- 771
.||.|..........|::|.| :.::|:..:| ||::
Worm 884 DGFTEPSTPATPLMGATSSKKKSYRRPAVVVAKSRKKKSVDD-----SDDDDFYPQRGRGKKKGG 943
Human 772 -----ADDADAAG-RDSPSNTSQSEQQESVDAEGP-----VVEKIMSSR---------------- 809
||..|.|| ..:.|:....|....:|...| |||||::.|
Worm 944 GGKKKADPTDEAGVEGAKSDDEDDEFLMKIDTPAPDPNAMVVEKILNMRMGKVEKKVPETEVAEG 1008
Human 810 -----------SVKKQ-KESG-----------------------EEVEIEEFYVKYKNFSYLHCQ 839
.|||: ||:| ||.|:|:|.:|:|..||:||:
Worm 1009 SEENGEEKSEEKVKKEPKENGENGESVGNGESSKSKTESETNEIEEEEVEQFLIKWKGRSYVHCE 1073
Human 840 W-ASIEDLEKDKRIQQKIKRFKAKQGQNKFLSEIE-DELFNPDYVEVDRIMDFARSTDDRGEPVT 902
| .:.|.||.|||::.||||||.| |..|.|| ||.||.|:|.|||::|.. |:|.|:...
Worm 1074 WKTAAELLEIDKRVEAKIKRFKVK----KMSSYIEDDEDFNSDFVIVDRVVDLI--TEDDGQEFV 1132
Human 903 HYLVKWCSLPYEDSTWE--------------RRQDIDQAKIEEFEKLMSREPETERVERPPADDW 953
|:||.||.||:.||| .||.||.|||.| .:||..::|
Worm 1133 --LIKWKSLGYEEVTWEPIEMIPADKVELWRERQVIDPAKIRE-------------KQRPEPEEW 1182
Human 954 KKSESSREYKNNNKLREYQLEGVNWLLFNWYNMRNCILADEMGLGKTIQSITFLYEIYLKGIHGP 1018
||..:|:.:||.|.|||||.|||:|||:.:||.:|||||||||||||:|:||||..||..|||||
Worm 1183 KKMSTSKVWKNGNSLREYQFEGVDWLLYCYYNAQNCILADEMGLGKTVQTITFLSRIYDYGIHGP 1247
Human 1019 FLVIAPLSTIPNWEREFRTWTELNVVVYHGSQASRRTIQLYEMYF-------KDPQGRVIKGSYK 1076
|||:.|||||.||.|||.|||::|.:|||||..:|..:|.||::: |:.: |...|
Worm 1248 FLVVVPLSTIQNWVREFETWTDMNAIVYHGSAYAREVLQQYEVFYDKRHCGAKNWK----KNFVK 1308
Human 1077 FHAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRNCKLL-EGLKMMDLEHKVLLTGTPLQNT 1140
..|:|||||.:::|...|:.||||..|||||||||||||||| .||....:||:||||||||||.
Worm 1309 IDALITTFETVVSDVEFLKKIPWRVCVIDEAHRLKNRNCKLLVNGLLAFRMEHRVLLTGTPLQNN 1373
Human 1141 VEELFSLLHFLEPSRFPSETTFMQEFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKEETI 1205
::||||||:||.|.:|.:..||:::||..:|::||||||.||||||||||||||||:|.||||||
Worm 1374 IDELFSLLNFLHPQQFDNSATFLEQFGSCQTDDQVQKLQEILKPMMLRRLKEDVEKSLGPKEETI 1438
Human 1206 IEVELTNIQKKYYRAILEKNFTFLSKGGGQANVPNLLNTMMELRKCCNHPYLINGAEEKILEEFK 1270
|||:|:::|||:||||||:||:.|.|| .:.|:|:|.|||||||||||:|||||||.|:.:|:
Worm 1439 IEVQLSDMQKKFYRAILERNFSHLCKG---TSAPSLMNVMMELRKCCNHPFLINGAEEAIMNDFR 1500
Human 1271 ETHNAESPDFQLQ-----AMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQMVRCLDILEDYLIQRR 1330
..| ||:..: |:|||:||:|||:||||||:..||:||||||||:.||:||::||...
Worm 1501 LAH----PDWDEETLAHKALIQASGKVVLIEKLLPKLRKDGHKVLIFSQMVKVLDLLEEFLISMS 1561
Human 1331 YPYERIDGRVRGNLRQAAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQ 1395
||:|||||.|||:|||||||||||.:||||||||||||||||||||||||.||||||||||||||
Worm 1562 YPFERIDGNVRGDLRQAAIDRFSKENSDRFVFLLCTRAGGLGINLTAADTVIIFDSDWNPQNDLQ 1626
Human 1396 AQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRENATNGVQQLSKKEI 1460
||||||||||.|.||:|||||.|:||||||||||||||||||||||.:..: ..|. .||||::
Worm 1627 AQARCHRIGQKKLVKVYRLITSNTYEREMFDKASLKLGLDKAVLQSTTALK--AEGT-ALSKKDV 1688
Human 1461 EDLLRKGAYGALMDEEDEGSKFCEEDIDQILLRRTHTITIESEGKGSTFAKASFVASGNR-TDIS 1524
|:||:|||||::||||:|.|||.||||:.||.|||.|||:|:..|||.||||:|.:|.|: .||.
Worm 1689 EELLKKGAYGSIMDEENESSKFNEEDIETILQRRTQTITLEAGQKGSLFAKATFNSSHNKGDDID 1753
Human 1525 LDDPNFWQKWAKKAELDIDAL----NGRNNLVIDTPRVRKQTRLYSAVKEDELMEFSDLESDSEE 1585
:|||.||.|||:||::|::.. :|| .|:|:.| ||:|:.:...|::...:.|: ||.:.:
Worm 1754 IDDPEFWTKWAEKAQVDVEKATATPDGR-ELIIEEP--RKRTKRFEENKDEGDSDGSE-ESGNRK 1814
Human 1586 KPCA---KPRRPQDKSQGY-----------ARSECFRVEKNLLVYGWGRWTDILSHGRYKRQLTE 1636
:..| |.||..|:...| :::|.|:|||.|..||||||.:|..:| :.:::|
Worm 1815 RGAAEKRKRRRGNDEDGDYSGSYRPDELATSKAEYFKVEKVLAQYGWGRWAEIKKYG--ELEISE 1877
Human 1637 QDVETICRTILVYCLNHYKGDENIKSFIWDLITPTADGQTRALVNHSGLSAPVPRGRKGKKVKAQ 1701
||:|.:.||:|::|:..::||:.|:.|:::||.| .|: ::.:|:.|.
Worm 1878 QDIEHMSRTLLLHCIREFRGDDRIRQFVFNLIRP------------QGI-------QENQKLGAG 1923
Human 1702 STQPVVQDADW--LASCNPDALFQEDSYKKHLKHHCNNSGNNATDQLYVLASCDLEQVIQPLEDS 1764
| :.:..| |...||.:...:.::::|:..|.|.
Worm 1924 S----MYNQGWAGLPEFNPPSFALDSAFQRHVHRHANK--------------------------- 1957
Human 1765 LSWVLLRVRMLYYLRQEVIGDQADKILEGADSSEADVWIPE-PFHAEVPADWWDKEADKSLLIGV 1828
:::::.||.:|...:|||:. .::|..:....|:.:|| |..:|...:.||.:.||..|||.
Worm 1958 ---LMVKIDMLKHLEIHLIGDER-ALVEDFNVKWTDIKLPEMPTISETFIEGWDSDCDKCFLIGC 2018
Human 1829 FKHGYEKYNSMRADPALCFLERVGMPDAKAIAAEQRGTDMLADGGDGGEFDREDEDPEYKPTRTP 1893
::||.:.::::|.|..|||.| |.:|.
Worm 2019 WRHGLDNFDAIRVDENLCFAE-------KNLAV-------------------------------- 2044
Human 1894 FKDEIDEFANSPSEDKEESMEIHATGKHSESNAELGQLYWPNTSTLTTRLRRLITAYQRSYKRQQ 1958
||..:....|.|||:|:.|:|.
Worm 2045 ---------------------------------------WPGQTDFWLRFRRLLTSSQKSV---- 2066
Human 1959 MRQEALMKTDRRRRRPREEVRALEAEREAIISEKRQKWTRREEADFYRVVSTFGVIFDPVKQQF- 2022
.:.:.: :..||:|||.:|.|||.::| ||...
Worm 2067 --------------------------HDPVYN--KLNWTKREEQEFIRVVRSYG-----VKTNIG 2098
Human 2023 -----DWNQFRAFAR-LDKKSDESLEKYFSCFVAMCRRVCRMPVKPDDEPPDL--SSIIEPITEE 2079
||..|:..:. |:||:||...:...|.:|||:|. ....|.:|.|| :..|:|:...
Worm 2099 EGGNEDWTIFKTLSPILEKKTDEDCHEQLMCVLAMCQRA---QGSNDLKPIDLKRAMSIDPMPTR 2160
Human 2080 RASRTLYRIELLRKIREQVLHHPQLGERLKLCQPSLDLPEWWECGRHDRDLLVGAAKHGVSRTDY 2144
:|.:.:.||.|:||:...|....:| .|:||: :..:|..| |.:||::|:....:.|:.:...
Worm 2161 KAIKMMNRISLMRKVHTMVQTLSEL--NLELCE-TTGMPSGW-CMQHDKELMEICDQCGLDQLAA 2221
Human 2145 HILNDPELS-------------FLDAHKNFAQNR--GAGNTSSLNPLAVGFVQTPPVISSAHIQD 2194
::||.|..: .|:........: |..:..::|.......:....:::|..|.
Worm 2222 NVLNKPAFTKIVRPSETTLLRRLLEIVATIESGKWCGVADVETVNDSDSEDKKDMAAVAAAQAQF 2286
Human 2195 ERVLEQAEGKVEE---PENPAAKEKCEGKEEEEETDGSGKESKQECEAEASSVKNELKGV----- 2251
.|:.:|.:.:.:. ..:.:|..|...|....:.|...:..:|....:..|...|...:
Worm 2287 LRLQQQQQQQQQAAAVAASSSASRKASRKRPNNDNDAKMRAMQQMLMGQGGSGAAEYASMIALML 2351
Human 2252 --EVGADTGSKSISE--------------KGSEEDEEEKLEDDDKSEESSQPEAGAVSRGKNFDE 2300
::.|.:|.::::. .|:.:.:::......|...|||..|.| ::
Worm 2352 MPQMMAASGGQNMTAAQQQALNQMLTMLIAGAVQQQQQAQPSTSKGASSSQSSAQA-------NQ 2409
Human 2301 ESNASMSTARDETRDGFYMEDGDPSVAQLLHERTFAFSFWPKDRVMINRLDNICEAVLKGKWPVN 2365
.:.|..:.. ::||:....:.:.| ..|...:.:...:.||:| ...:|
Worm 2410 AAQAQAAAV---------------ALAQVAAAASASTS--SADAQAVAQQQQVLEALL--AMSMN 2455
Human 2366 RRQMFDFQGLIPGYTPTTVDSPLQKRSFAELSMVGQASISGSEDITTSPQLSKEDALNLSVPRQR 2430
...:....|.......:|..:|.:.:...:......| |.:...:...|..|:..:|:
Worm 2456 PAALAALTGTSSSTGTSTPSAPKKSKPAPQKESTSSA--------TAAAAAASAQAAALAAAQQQ 2512
Human 2431 RRRRRKIEIEAERAAKRRNLME-MVAQLRESQVVSENGQEKVVDLSKASREATSSTSNFSSLSSK 2494
:::.::.:..|::|...:...| ::.:|.|...| |.:::..|:..|::|.
Worm 2513 QQQAQQAQQAAQQAQSAKTQEELLILRLLELAGV---GMQELAKLNTMSKDAR------------ 2562
Human 2495 FILPNV------STPVSDAFKTQMELLQAGLSRTPTRHLL---------------------NGSL 2532
:|.: |.||| .|.|.|.|. ||:
Worm 2563 --VPMIHKQTRESLPVS--------------KRPPIRDLTVFVMSNPEWSIDIPLFNEMSGNGT- 2610
Human 2533 VDGEPPMKRRRGRRKNVEGLDLLFMSHKRTSLSAEDAEVTKAFEEDIETPPTRNIPSPGQLDPDT 2597
..|..|..:....|.......|...:.|.::...|.:..|.:..|......|.||.....|..|.
Worm 2611 GSGAAPSSKAASSRPTPAATPLAVATPKPSTPKVEKSSATPSAPETPSASATCNIKIGESLQFDD 2675
Human 2598 RIPVINLEDGTRLVGEDAPKNKDLVEWLKLHPTYTVDMPSYVPKNADVLFSSFQKPKQKRHRCRN 2662
.|.|.|.:.|..|.....||..:|..||..:|.|.|...| .||:..
Worm 2676 MISVFNRKTGELLAASKWPKATELSAWLDANPDYNVHANS-------ALFAHL------------ 2721
Human 2663 PNKLDINTLTGEERVPVVNKRNGKKMGGAMAPPMKDLPRWLEENPEFAVAPDWTDIVKQSGFVPE 2727
.:|||.:..:.| ..|....:...|.....|.....
Worm 2722 ------------------------SLGGAHSDRIGD------ATPAVTASVPSTPTPSTSASAAN 2756
Human 2728 SMFDRLLTGPVVRGEGASRRGRRPKSE-------IARAAAAAAAVASTSGINPLLVNSLFAGMDL 2785
:....|.....| :.|.:....|.|. .|:||||.||.:....|....:..|...|.|
Worm 2757 AQLMALALAQQV--QQAQQTPSTPTSSKSRSATAAAQAAAAQAAASQQDAITKQQLEMLQMQMML 2819
Human 2786 TSLQNLQNLQSLQLAGLMGFPPGLATAATAGGDAKNPAAVLPLMLPGMAGLPNVFGLGGLLNNPL 2850
...|....|||:...|. |:.|.:||...:.. .||..:..: ..
Worm 2820 QQYQQAAALQSMLYGGY-----GMPTTSTAASSSST---------------ANVASMAAM---AA 2861
Human 2851 SAATGNTTTASSQGEPEDSTSKGEEKGNENEDENKDSEKSTDAVSAADSANGSV-----GAATAP 2910
:|...:|.|.|.|.....|| .||.||::|.:.:.|| .||.|.
Worm 2862 AAQAASTPTTSKQASASTST------------------PSTSAVASAQTPSTSVPSTSSQAAAAA 2908
Human 2911 AGLPSNPLAFNPFLLSTMA--PGLFYPSMFLPPGLGGLTLPGFPALAGLQNAVGSSEEKAADKAE 2973
|...::....||.||:.:. |.:....|...|.: ..|||..|.. ...::.:|.|::
Worm 2909 ASSANSGEDINPLLLTALMQNPAILQSMMLSDPSI-------LAALAAAQQQ-QQQQQPSAKKSK 2965
Human 2974 2973
Worm 2966 2965
| 
