Protein Alignment G2E3 and pie

DIOPT Version :10

• Sequence 1: NP_060239.2
• Gene: G2E3 / 55632
• HGNCID: 20338
• Length: 706
• Species: Homo sapiens
• Sequence 2: NP_524740.2
• Gene: pie / 44315
• FlyBaseID: FBgn0005683
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 296
• Identity: 97/296 - (32%)
• Similarity: 156/296 - (52%)
• Gaps: 35/296 - (11%)

Human     8 DSQNLACVFCRKHDDCPNKYGEKKTKEKW----NLTVHYYCLLMSSGIWQRGKEEEGVYGFLIED 68
            |::.|.|:.|:..|.....:||      |    ||.|||:|||:|:.:.|||.:..|:.|||:.|
  Fly     3 DNKELQCLICKYSDTDDLVFGE------WMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRD 61

Human    69 IRKEVNRASKLKCCVCKKNGASIGCVAPRCKRSYHFPCGLQRECIFQFTGNFASFCWDHRPVQII 133
            ||:|...|.|.||..|.|.|||:.|  .||:..:|..|||:...:|:|.|.:.|:|:..||:
  Fly    62 IREEAAAAEKRKCWYCNKIGASLQC--DRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPM--- 121

Human   134 TSNNYRESL--------PCTICLEFIEPIPSYNILRSPCCKNAWFHRDCLQVQAINAGVFFFRCT 190
              ::|:..|        .|.||...|..:..:.::...||:..:.|:.|::..|:.:| ::.||.
  Fly   122 --DDYKRQLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSG-YYLRCI 183

Human   191 ICNNSDIFQKEMLRMGIHIPEKDASWELEENAYQELLQHYERCDVRRCRCKEGRDYNAPDSKWEI 255
            .| .|:.|:..:....:.:|::||:||.:.|||:||.:...:||...|.|..||.||.  ..|.|
  Fly   184 WC-RSERFRDSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYNR--LSWVI 245

Human   256 KRCQCCGSSGTHLAC--SSLRSWEQ----NWECLEC 285
            ..|..|.::..||.|  .:||..::    :::|..|
  Fly   246 LCCSSCAATSAHLKCLVGALRLPKKRERTDFKCSMC 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
G2E3	NP_060239.2	ePHD_PHF7_G2E3_like	14..127	CDD:277139	47/116 (41%)
		PHD_PHF7_G2E3_like	232..285	CDD:276971	18/58 (31%)
		HECTc	411..692	CDD:474882
pie	NP_524740.2	PHD_SF	9..117	CDD:473978	47/115 (41%)
		PHD_SF	224..>260	CDD:473978	14/37 (38%)
		PRK10263	<265..>493	CDD:236669	4/17 (24%)