Protein Alignment SLC39A4 and foi

DIOPT Version :10

• Sequence 1: NP_570901.3
• Gene: SLC39A4 / 55630
• HGNCID: 17129
• Length: 647
• Species: Homo sapiens
• Sequence 2: NP_523974.3
• Gene: foi / 38976
• FlyBaseID: FBgn0024236
• Length: 706
• Species: Drosophila melanogaster
• Alignment Length: 782
• Identity: 184/782 - (23%)
• Similarity: 283/782 - (36%)
• Gaps: 295/782 - (37%)

Human    52 ADRVHCANGPCGKCLSVEDALGLGEPEGSGLPPGPVLEARYVARLSAAAVLYLSNPEGTCEDARA 116
            |.|:||.:       .:|..||          |..|.......:|:|.....|| |.....|.|.
  Fly    16 AHRLHCQD-------HIESLLG----------PARVTTHNSQDQLNARVYTNLS-PSSETTDRRQ 62

Human   117 GLWASHADHLLALLESPKALTPGLSWLLQRMQARAAG---------QTP--------KMACVD-- 162
            ...||..|.......||.:          |.:.|.||         :.|        |:...|
  Fly    63 QRSASGDDDTFNYSISPPS----------RREKRHAGHEHGPTSESRVPQITQYYLEKLMAQDEL 117

Human   163 ---------IPQLLEEAVGAGA------PGSAGGVLAALLDHVRSGSCFHALPSPQYFVDFVFQQ 212
                     :.||...::.:||      |||      .|:.||:.....||            ..
  Fly   118 MNSSGFDGLLQQLSLHSLASGASEGTCVPGS------RLVHHVQPHDHHHA------------HH 164

Human   213 HSSEVPMTLAELSALMQRLGVGREAHSDHSHR-------HRGASSRDPVPLISSSNSSSVW---D 267
            |..|                       |||.:       ..|.:|....|.:.::|:..:.   .
  Fly   165 HEEE-----------------------DHSLQLNNCTLIQNGTTSNVICPSLPNNNTHPLGKEAK 206

Human   268 TVCLSARDVM-----AAYGLSEQAGVTPEAWAQLSPALLQQQLSGACTSQSRPPVQDQLSQSER- 326
            ...||.:|::     ..|.|..|:|      ..:.||:|           |.....::|.::|:
  Fly   207 NFTLSDKDLLHLCPILLYELKAQSG------GCIEPAIL-----------SDIDTTEELLEAEKD 254

Human   327 ------YLYGSLATLLICLCAVFGLLLLTCTGCRGVTHYILQTFLSLAVGAVTGDAVLHLTPKVL 385
                  ::|..::.....:..:.|:.::...|.| ...||:|..::||||.:||||:|||.|.
  Fly   255 KDIFYVWIYAFISVFACGILGLVGVAIIPFMGSR-YYKYIIQYLVALAVGTMTGDALLHLLPH-- 316

Human   386 GLHTHSEEGLSPQPTWRLLAMLAGLYAFFLFENLFNLL-------------------LPRDPE-D 430
            .|....|.|:    ..:.|..|.|:..|::.|:...::                   :.|||: .
  Fly   317 SLAGQDERGM----IMKGLGCLGGIIFFYVMEHALTMISEWRKSVEKKETKKPSRAKVMRDPDSS 377

Human   431 LEDGPCG-------HSSHSH-------------------------GGHSHGVSLQLAPSELRQPK 463
            :.:...|       :||:.:                         ||.:..|      :|||...
  Fly   378 VNNSVAGDKICKQKYSSYPYCYDEITMNNKQSEWMHLPFDVAAGAGGDAPSV------AELRNGV 436

Human   464 PPHEGSRADLVAEESPELLNP-------------------------------------------- 484
            ..|:||.....|.||  |::|
  Fly   437 GDHDGSNDMAAAAES--LISPLHTNCVEMNHHNHNHKHNSHQQNHEGQDSNTIVTDLDGNAVYAV 499

Human   485 ------------------------------------EPRRLSPELRLLPYMITLGDAVHNFADGL 513
                                                .|..||    .:.:||.:||.:|||.||:
  Fly   500 NKAKDKDSRNDHVTVILREHESSHHGHSHRHGHVHSPPETLS----AVAWMIIMGDGLHNFTDGM 560

Human   514 AVGAAFASSWKTGLATSLAVFCHELPHELGDFAALLHAGLSVRQALLLNLASALTAFAGLYVALA 578
            |:|||||.:...|.:||||||||||||||||||.|:.||:||:.|:..||.:.:.:|.|:...:|
  Fly   561 AIGAAFAENIAGGFSTSLAVFCHELPHELGDFAILIKAGMSVKSAVYYNLLTGVLSFIGMIFGIA 625

Human   579 VGVSEESEAWILAVATGLFLYVALCDMLPAMLKVRDPRPWLLFLLHNVGLLGGWTVLLLLSLYED 643
            .|.|::...|:.|||.|||:|:||.||:|.:  ....:....|||..:|:|.|..::||::|||.
  Fly   626 FGQSQDVAQWMFAVAAGLFIYIALVDMMPEI--SASHKSLGQFLLQILGMLSGVGIMLLIALYEG 688

Human   644 DI 645
            |:
  Fly   689 DL 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SLC39A4	NP_570901.3	ZIP4_domain	46..196	CDD:465698	38/177 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	236..255		5/25 (20%)
		Zip	328..638	CDD:396884	117/441 (27%)
		Essential for SLC39A4 endocytosis. /evidence=ECO:0000269|PubMed:32348750	452..454		0/1 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	458..484		10/25 (40%)
foi	NP_523974.3	Zip	258..684	CDD:396884	118/446 (26%)