DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZDHHC7 and Hip14

DIOPT Version :9

Sequence 1:	NP_001139020.1	Gene:	ZDHHC7 / 55625	HGNCID:	18459	Length:	345	Species:	Homo sapiens
Sequence 2:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	321	Identity:	72/321 - (22%)
Similarity:	111/321 - (34%)	Gaps:	105/321 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    35 VADRVWFIRDGCGMICAVMTWLLVAYAD----FVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALS 95
            :|.:.||          .:|||:  |.|    |..|...|:.|...|      |.|
  Fly   356 LATKAWF----------YVTWLM--YIDDAVSFTATVCFLISSLLLW------VCF--------- 393

Human    96 SHLRTMLTDPEKSSDCRPSACTVKTGLDPTLVGICGEGTESVQSLLLGAVPKGNATKEYMESLQL 160
              |::...||                      ||.....|.....::....:|        .:..
  Fly   394 --LKSWKGDP----------------------GIIRPTREQRFKTIIELSERG--------GIGF 426

Human   161 KPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVH 225
            :|...   |..|...:|.|:.|||:|.||:.:.|||||||.||:|.||..:|:.|...:
  Fly   427 EPASF---CSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWML------ 482

Human   226 ALILCGFQFISCVRGQWTECS----DFSPPITVI-----LLIFLCLEGLLFFTFTAVMFGTQIHS 281
             ||:|.:......:....:|:    ||...:..|     .:.::....||..::..::...|.:.
  Fly   483 -LIMCAWMLYGGSKYYVNQCNVRFDDFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQ 546

Human   282 -ICNDETEIERLKSEKPTWERRLRWEGMKSVF-GGPPSLL------------------WMN 322
             ||...|..||:...:   .|..:.:|..|.| .||...|                  |||
  Fly   547 VICLGMTTNERMNRGR---YRHFQAKGGHSPFTRGPIQNLVDFLECSCFGLVQPKRVDWMN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZDHHC7	NP_001139020.1	zf-DHHC	168..295	CDD:307600	39/136 (29%)
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	40/142 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810