Protein Alignment TTC27 and CG5290

DIOPT Version :10

• Sequence 1: NP_060205.3
• Gene: TTC27 / 55622
• HGNCID: 25986
• Length: 843
• Species: Homo sapiens
• Sequence 2: NP_649026.1
• Gene: CG5290 / 39998
• FlyBaseID: FBgn0036772
• Length: 798
• Species: Drosophila melanogaster
• Alignment Length: 817
• Identity: 249/817 - (30%)
• Similarity: 389/817 - (47%)
• Gaps: 80/817 - (9%)

Human    56 FNSTTT-----AEEKIDSYLEKQVVTFLDYSTDL-------------DTTERQQLIFLLGVSSLQ 102
            ||...|     |:|.:.....:|.:..:|...::             |....|...|||.:.:
  Fly    14 FNDAVTVEDLPADETLRQLWTRQKLWTIDELREILQRWQEHVKPDPNDNPTSQLKDFLLLIFA-- 76

Human   103 LFVQSNWTGPPVDLHPQDFLSSVLFQQFSEVKGLDAFVLSLLTLDGESIYSLTSKPILLLLARII 167
             |||:::|||...|.....:.|.|     |::.|||  |..|...||.:........|||:||.|
  Fly    77 -FVQNSFTGPFDKLEEYQQIHSEL-----ELEKLDA--LEKLKASGEELNPNVKSVELLLIAREI 133

Human   168 LVNVRHKLTAIQSLPWWTLRCVNIHQHLLEERSPLLFTLAENCIDQVMKLQNLFVDDSGRYLAIQ 232
            |..:.......:.|.||.||.:.:|||:|::   |..:|.|........||..|.....|.|...
  Fly   134 LEGLLENHPESKVLIWWRLRLICLHQHVLDD---LAASLYEQFKSAAGHLQAHFNQFESRELQSL 195

Human   233 FHLECAYVFLYYYEYRKAKDQLD-IAKDISQLQIDLTGALGKRTRFQENYVAQLILDVRREGDVL 296
            ..||.|..:|.::....|...|| :.|.: |:::.:.|.||.||:||:..:.||.|.|....:
  Fly   196 LLLELANGYLQFHRSEIASQILDELCKHL-QVELKVEGLLGVRTKFQQKALPQLCLKVEHLNE-- 257

Human   297 SNCEFTPAPTPQE--HLTKNLELNDDTILNDIK---LADCEQFQMPDLCAEEIAIILGICTNFQK 356
             .....||....|  .|.|.|.|.|||.|..|:   |.|.|...:|.:..   |::|......::
  Fly   258 -QQPLPPAVQTNETTKLPKLLLLEDDTRLERIRFVELKDNEVMTLPSVLQ---ALVLAKVKQLKR 318

Human   357 NNPVHTLTEVELLAFTSCLLSQ---PKFWAIQTSALILRTKLEKGSTRRVERAMRQTQ---ALAD 415
            :.|...|.:.:|..:|..||.|   |  :.::.|||:|....|....|.|||:.:|.:   .|.|
  Fly   319 STPKDRLADEQLEPYTQTLLYQEHGP--FQVRQSALLLNCLQESNQRRTVERSWKQCEECVKLLD 381

Human   416 QFEDKTTSVLERLKIFYCCQVPPHWAIQRQLASLLFELGCTSSALQIFEKLEMWEDVVICYERAG 480
            ..|:: .|:..||...:...:.|.|.:|.||..||..||.|.:||.|..::..|:.|:.||....
  Fly   382 TSEEE-LSLRSRLSYGFAAHLSPKWQVQLQLVDLLRSLGMTKTALDICLRIHAWQQVIECYTSLE 445

Human   481 QHGKAEEILRQELEKKETPSLYCLLGDVLGDHSCYDKAWELSRYRSARAQRSKALLHLRNKEFQE 545
            ...||.||:|||||||.|..|||||||.:.|.|.|::||..|:..|.:||........|:.::.:
  Fly   446 LRHKAAEIIRQELEKKPTALLYCLLGDAIDDPSFYEQAWLYSKKTSGKAQAYWGNHFYRSADYAQ 510

Human   546 CVECFERSVKINPMQLGVWFSLGCAYLALEDYQGSAKAFQRCVTLEPDNAEAWNNLSTSYIRLKQ 610
            .::.||.|::||.:|..:....|...:.||.::.:.|.:.....|||:..|:||||:.:.|:|..
  Fly   511 AMDHFEISLEINNLQEAILLRCGYCAIQLERWEPAVKYYLAYTHLEPNGFESWNNLAKALIKLGD 575

Human   611 KVKAFRTLQEALKCNYEHWQIWENYILTSTDVGEFSEAIKAYHRLLDLRDKYKDVQVLKILVRAV 675
            |.:|.|.|.|||||||.:|::||||:|.|.|...:.:|::||.|:.:|:..|.|.:||..:|..|
  Fly   576 KQRAHRVLGEALKCNYSNWKVWENYMLVSVDTSHWDDAMRAYQRMAELKQHYLDQEVLTRIVYGV 640

Human   676 IDGMTDRSGDVATGLKGKLQELFGRVTSRVTNDGEIWRLYAHVYGNGQSEKPDENEKAFQCLSKA 740
              ...|.:|  ::.|..:|.:|.|:.:.:..|:..:|.|.|.|     ::.|   .|..:.|.|:
  Fly   641 --SKEDPAG--SSALIKRLIKLLGQQSIQHGNEPLVWELAALV-----AQTP---LKKAEKLVKS 693

Human   741 YKCDTQSNC-WEKDITSFKEVVQRALGLAHVAIKCSKNKSSSQEAVQMLSSVRLNLRGLLSKAKQ 804
            |:..|..:. ||    :..|...:||.|....  |..:.::..|.:|..|.|.:..:  |:.|:.
  Fly   694 YRAYTPKHLGWE----TKSEHALKALDLCLEV--CDLSVAAITEHIQEESEVMITSQ--LNSARL 750

Human   805 LFTDVATGEMSRELADDITAMDTLVTE-----LQDLS 836
            ..|. ....:.|.:..|::|..|...|     ::||:
  Fly   751 AGTS-CLNALKRAINVDVSAEQTAKVEQLEKRIEDLT 786

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TTC27	NP_060205.3	TPR 1	453..486		11/32 (34%)
		TPR 2	492..525		19/32 (59%)
		TPR repeat	499..520	CDD:276809	11/20 (55%)
		TPR	502..>674	CDD:440225	65/171 (38%)
		TPR 3	527..560		8/32 (25%)
		TPR repeat	527..555	CDD:276809	6/27 (22%)
		TPR repeat	560..590	CDD:276809	5/29 (17%)
		TPR 4	561..594		7/32 (22%)
		TPR repeat	595..623	CDD:276809	13/27 (48%)
		TPR 5	596..628		18/31 (58%)
		TPR 6	629..662		13/32 (41%)
		TPR repeat	629..657	CDD:276809	12/27 (44%)
CG5290	NP_649026.1	TPR	464..655	CDD:440225	70/194 (36%)
		TPR repeat	493..520	CDD:276809	6/26 (23%)
		TPR repeat	525..555	CDD:276809	5/29 (17%)
		TPR repeat	560..588	CDD:276809	13/27 (48%)
		TPR repeat	594..622	CDD:276809	12/27 (44%)