Protein Alignment PRKAA1 and AMPKalpha

DIOPT Version :10

• Sequence 1: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_477313.1
• Gene: AMPKalpha / 43904
• FlyBaseID: FBgn0023169
• Length: 582
• Species: Drosophila melanogaster
• Alignment Length: 611
• Identity: 339/611 - (55%)
• Similarity: 408/611 - (66%)
• Gaps: 109/611 - (17%)

Human    22 VKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPH 86
            ||||||:||.|||.|||||||:|:|::|..||||||||||||:||||||||||||||||||||||
  Fly    23 VKIGHYLLGATLGTGTFGKVKIGEHQITRVKVAVKILNRQKIKSLDVVGKIRREIQNLKLFRHPH 87

Human    87 IIKLYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILS 151
            ||||||||||||||||:|||||||||||||.|:|:               |.|.::||.||||:|
  Fly    88 IIKLYQVISTPSDIFMIMEYVSGGELFDYIVKHGK---------------LQEHQARRFFQQIIS 137

Human   152 GVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLY 216
            |||||||||:|||||||||:|||.:|:.|||||||||||.||||||||||||||||||||||:||
  Fly   138 GVDYCHRHMIVHRDLKPENLLLDHNMHVKIADFGLSNMMLDGEFLRTSCGSPNYAAPEVISGKLY 202

Human   217 AGPEVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMK 281
            |||||||||.||||||||||||||||:||||||:||..|||..|:|||..|::|:..||||||:|
  Fly   203 AGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFRKIKSGIFPIPEYLNKQVVNLVCQMLQVDPLK 267

Human   282 RATIKDIREHEWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPL 346
            ||.|::|::||||::|||.||||......|.:||..|:.|||.||...|.||.:.|.:.:..|.|
  Fly   268 RANIEEIKKHEWFQKDLPAYLFPSSIEQDSNVIDTYAVAEVCTKFGVKETEVHNSLLSGDPHDQL 332

Human   347 AVAYHLIIDNRRI-------MNEAKDFYLATSP--------PDSFLDDHHL-------------- 382
            |:||||||||:|.       :||..:|::|.||        |.|.: ||..
  Fly   333 AIAYHLIIDNKRFADDAANQINEINNFFVAGSPPPPPPPPVPQSSM-DHQAPLATVTVGGGTSAS 396

Human   383 --------------------TRPHPERVPFLVAETPRARHTLDELN-------PQKSKHQG--VR 418
                                .||||||:..:     |.|.....:.       |:|:...|  ::
  Fly   397 SGTATPVPPVAGGTPSSTIPIRPHPERIAPM-----RDRQLAMSVQTSGGGAFPEKTARGGTPIK 456

Human   419 KAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSR 483
            :|||||||||||:|||||.||.||:|.|.||||::|||::||||:|..|..:|||||||||||::
  Fly   457 RAKWHLGIRSQSKPNDIMLEVYRAMKALSYEWKIINPYHVRVRRQNVKTGKFSKMSLQLYQVDAK 521

Human   484 TYLLDFRSIDDEITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQGKSSEVSLTSSVTSLDSSPV 548
            :|||||:|:.::..|                    |..|...|        |||....|: |..:
  Fly   522 SYLLDFKSLTNDEVE--------------------QGDDVIME--------SLTPPPLSV-SGVM 557

Human   549 DLTPRPGSHTIEFFEMCANLIKILAQ 574
            .|.| .|.||:|||||||.||..||:
  Fly   558 PLQP-TGHHTMEFFEMCAALIIQLAR 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	205/269 (76%)
		UBA_AID_AAPK1	311..375	CDD:270586	32/78 (41%)
		AMPKA1_C	419..572	CDD:213384	75/152 (49%)
AMPKalpha	NP_477313.1	STKc_AMPK_alpha	25..280	CDD:270981	205/269 (76%)
		UBA_AID_AMPKalpha	297..360	CDD:270521	27/62 (44%)
		AMPKA_C	457..580	CDD:213378	75/152 (49%)