Protein Alignment PRKAA1 and KP78b

DIOPT Version :10

• Sequence 1: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_650065.1
• Gene: KP78b / 41361
• FlyBaseID: FBgn0026063
• Length: 604
• Species: Drosophila melanogaster
• Alignment Length: 587
• Identity: 168/587 - (28%)
• Similarity: 260/587 - (44%)
• Gaps: 126/587 - (21%)

Human    25 GHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIK 89
            |.|.:..|||.|.|.|||:..|..||.:||:|::::..:.:: ...|:.||:..:|...||:|::
  Fly    61 GVYKIIKTLGKGNFAKVKLAIHLPTGREVAIKLIDKTALNTI-ARQKLYREVNIMKKLNHPNIVR 124

Human    90 LYQVISTPSDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVD 154
            |.|||.:...:::|||||||||||:|:.||||               :.|:::|.||:|::|.::
  Fly   125 LLQVIESERTLYLVMEYVSGGELFNYLVKNGR---------------MRERDARVLFRQLVSAIE 174

Human   155 YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGP 219
            |||...:||||||.||:|||..|..||||||.|........|.|.||||.|||||:..|:.|:||
  Fly   175 YCHSKSIVHRDLKAENLLLDQQMKLKIADFGFSTTFEPKAPLETFCGSPPYAAPELFRGKKYSGP 239

Human   220 EVDIWSSGVILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHMLQVDPMKRAT 284
            |||.||.||:||.|:.|:||||..::..|..::..|.:..|.|::....||::..|.::|.:|.:
  Fly   240 EVDSWSLGVVLYTLVSGSLPFDGTNLKELRDRVLRGKYRVPYYVSIECESLIRKFLVLNPTQRTS 304

Human   285 IKDIREHEW----FKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDP 345
            :..:....|    ::|......|.|.|                  .:..:...||.|.|..|: |
  Fly   305 LSAVMADRWINMGYEQGNGLRPFQEKP------------------MDLHDVNRLSLLSNMGHK-P 350

Human   346 LAVAYHL-------IIDNRRIMNEAKDFYLATSPPD-SFLDDHHLTRPHPERVPFLVAE------ 396
            ..|...|       |.....:::.||....|.|... |...:.....|...|:|..:|.
  Fly   351 RDVEQSLKNQKFDDIYCTYMLLDVAKPRSTACSEKSGSSFRETPTAMPGSSRIPVPIAAPNVTIS 415

Human   397 ----------------------TPRARHTLDEL------------------NPQKSKHQGV-RKA 420
                                  .||..:.|..|                  ||::|:...: :.|
  Fly   416 QVTFALDKSTPNRPAATSIRPMAPRLANALTPLPLTPPPKKYICCSASKAANPRRSEPSSIPQSA 480

Human   421 KWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTY 485
            ....|:.|   |.|:...:..|.::|....|:.:..:   :.::|:|.:.|:.|     ..:||.
  Fly   481 MPKKGVGS---PVDVKTTLLSAQRKLAVNQKLTSASH---QIRSPITQSPSQAS-----ECTRTP 534

Human   486 LLDFRSIDDEITEAK---------------SGTATPQRSGSVSNY------RSCQRSDSDAEAQG 529
            ...|..:|...|..|               ..|..|.|.|..|..      ||..:.:.|...||
  Fly   535 PTHFEMLDSTSTPLKVLKLVASNSQTPPSTENTNRPTRVGFFSKLSARFVRRSLHKGEKDISEQG 599

Human   530 KS 531
            ::
  Fly   600 RN 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	111/272 (41%)
		UBA_AID_AAPK1	311..375	CDD:270586	13/71 (18%)
		AMPKA1_C	419..572	CDD:213384	28/134 (21%)
KP78b	NP_650065.1	Protein Kinases, catalytic domain	63..314	CDD:473864	109/266 (41%)
		UBA_MARK_Par1	335..373	CDD:270522	9/38 (24%)