Protein Alignment PRKAA1 and Nuak

DIOPT Version :10

• Sequence 1: NP_996790.3
• Gene: PRKAA1 / 5562
• HGNCID: 9376
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_001369005.1
• Gene: Nuak / 41256
• FlyBaseID: FBgn0262617
• Length: 2803
• Species: Drosophila melanogaster
• Alignment Length: 547
• Identity: 169/547 - (30%)
• Similarity: 250/547 - (45%)
• Gaps: 141/547 - (25%)

Human    33 LGVGTFGKVKVGKHELTGHKVAVKILNRQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTP 97
            ||.||:|||::|.::.||.:||:|.:.:.||.:...:.:||||:|.:....||:||.:|:|....
  Fly    76 LGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNIIHIYEVFENR 140

Human    98 SDIFMVMEYVSGGELFDYICKNGRKSDVPGVVKTGSTKELDEKESRRLFQQILSGVDYCHRHMVV 162
            ..:.:|||:.:||||:||:.:.               |.|.|:|:||:|:|:.:.|.|||:|.:.
  Fly   141 EKMVLVMEFAAGGELYDYLSER---------------KVLTEEEARRIFRQVATAVYYCHKHKIC 190

Human   163 HRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSSG 227
            |||||.||:|||...|||||||||||:..|...|.|.||||.||:||::.|..|.|||||.||.|
  Fly   191 HRDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDCWSLG 255

Human   228 VILYALLCGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVIS-LLKHMLQVDPMKRATIKDIREH 291
            |:||.|:.|::|||..:...|.|:|..|.:|.|:  .||..| |::.||.|.|.|||:|:.|..|
  Fly   256 VLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPR--KPSRASTLIRDMLTVCPRKRASIEQICSH 318

Human   292 EWFKQDLPKYLFPEDPSYSSTMIDDEALKEVCEKFECSEEEVLSCLYNRNHQDPLAVAYHLIIDN 356
            .|                                  .:|.:.:|||
  Fly   319 WW----------------------------------VNENDNVSCL------------------- 330

Human   357 RRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVAETPRARHTLDELNPQKSKHQGVRKAK 421
                :.|:|                |....|.|:..|::.|| |..|.|:|....:  :|...||
  Fly   331 ----DLAED----------------LANQTPVRLDVLLSLTP-ATITADQLVVPSA--EGAAAAK 372

Human   422 WHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTYSKMSLQLYQVDSRTYL 486
                    :..|:                        ||.|.:.|.|.   ..:.....::...:
  Fly   373 --------AAANE------------------------RVPRSHSVGSI---RDMGPPNTEAERRI 402

Human   487 LDFRSIDDE--ITEAKSGTATPQRSGSVSNYRSCQRSDSDAEAQG----KSSEVSLTSSVTSLDS 545
            ||..:...|  :..:.:.|.||.:| .|...|..|.:.|...|.|    |..:.:.:|.|.|.|.
  Fly   403 LDMVAAGGEAALMPSPTRTITPAQS-PVQTKRKLQPTVSTENAAGTTAKKKEKPANSSFVISKDG 466

Human   546 SPVDLTP----RPGSHTIEFFEMCANL 568
            :|:...|    .|.:..:| .|..||:
  Fly   467 APLTEAPPTIIEPQATLME-AETIANI 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRKAA1	NP_996790.3	STKc_AMPK_alpha	24..294	CDD:270981	118/261 (45%)
		UBA_AID_AAPK1	311..375	CDD:270586	6/63 (10%)
		AMPKA1_C	419..572	CDD:213384	33/160 (21%)
Nuak	NP_001369005.1	STKc_NUAK	68..321	CDD:270975	119/295 (40%)